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F0T7W2

- HPRT_METLA

UniProt

F0T7W2 - HPRT_METLA

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanobacterium lacus (strain AL-21)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMSP868132:GI5U-201-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Metbo_0197
OrganismiMethanobacterium lacus (strain AL-21)
Taxonomic identifieri877455 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium
ProteomesiUP000007490: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415463Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF0T7W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0T7W2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFEKLKISLI EAPIIKKGDY NYFVHPITDG VPLVDPDVLK EAAEGIKKFG
60 70 80 90 100
NLNVDKIVCV EAMGIHIATA LSIITGIPFV VIRKRQYGLE GEVAVHQITG
110 120 130 140 150
YSHGELYING LKKGDKIILV DDVVSTGGTM IAVLKAMEKM GIEIVDVFAI
160 170 180 190
VEKGEGKYIV EGETGFEVKS LVKVNVVDGK VQIEGSRDEN
Length:190
Mass (Da):20,685
Last modified:May 3, 2011 - v1
Checksum:iB8CFAA58C76D23E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002551 Genomic DNA. Translation: ADZ08449.1.
RefSeqiWP_013643800.1. NC_015216.1.
YP_004289421.1. NC_015216.1.

Genome annotation databases

EnsemblBacteriaiADZ08449; ADZ08449; Metbo_0197.
GeneIDi10276623.
KEGGimel:Metbo_0197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002551 Genomic DNA. Translation: ADZ08449.1 .
RefSeqi WP_013643800.1. NC_015216.1.
YP_004289421.1. NC_015216.1.

3D structure databases

ProteinModelPortali F0T7W2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADZ08449 ; ADZ08449 ; Metbo_0197 .
GeneIDi 10276623.
KEGGi mel:Metbo_0197.

Phylogenomic databases

KOi K00759.
OMAi IATDIPY.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MSP868132:GI5U-201-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AL-21.

Entry informationi

Entry nameiHPRT_METLA
AccessioniPrimary (citable) accession number: F0T7W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3