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Protein

Alanine racemase

Gene

Sgly_2703

Organism
Syntrophobotulus glycolicus (strain DSM 8271 / FlGlyR)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Sgly_3297), Alanine racemase (Sgly_2703)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Active sitei262 – 2621Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSGLY645991:GHJ4-2766-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Sgly_2703Imported
OrganismiSyntrophobotulus glycolicus (strain DSM 8271 / FlGlyR)Imported
Taxonomic identifieri645991 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeSyntrophobotulus
ProteomesiUP000007488 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi645991.Sgly_2703.

Structurei

3D structure databases

ProteinModelPortaliF0SXB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiWKGGAAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0SXB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGMRPAWAC IDLGALRRNY RRICRQTNSE VMAIVKANAY GHGALEIVRT
60 70 80 90 100
LKEEGVRRFG VAILEEALQI REKFPEVTVM LIGPTMPDQA ERIVAEGIIP
110 120 130 140 150
EVFRLEQAEA FSLEAEKKGI PAILHIKVDT GMGRIGFQED ALENILKIAQ
160 170 180 190 200
LPGIEIEGIY THLATADEID LGFAFTQLKR FDGLYESLKT AGLNIPMRHV
210 220 230 240 250
ANSAAILQLR DQEYELCRPG LMLYGQLPMN HWEGENGFEP LMSLKARIVH
260 270 280 290 300
LKKIAAGDSV SYGRTFIAQA PTLVATLPLG YADGLRRSLS NNWNVIVKGR
310 320 330 340 350
YAPVIGRICM DQTMIDVTGI EGVEIGDEVT ILGSEGKSSL TAAQMAECAG
360 370
TISYEILCGI SQRVPRVYID TSQIPK
Length:376
Mass (Da):41,495
Last modified:May 3, 2011 - v1
Checksum:i2EF60465963781AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002547 Genomic DNA. Translation: ADY56976.1.
RefSeqiWP_013625796.1. NC_015172.1.
YP_004266977.1. NC_015172.1.

Genome annotation databases

EnsemblBacteriaiADY56976; ADY56976; Sgly_2703.
KEGGisgy:Sgly_2703.
PATRICi47036420. VBISynGly105927_2897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002547 Genomic DNA. Translation: ADY56976.1.
RefSeqiWP_013625796.1. NC_015172.1.
YP_004266977.1. NC_015172.1.

3D structure databases

ProteinModelPortaliF0SXB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi645991.Sgly_2703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADY56976; ADY56976; Sgly_2703.
KEGGisgy:Sgly_2703.
PATRICi47036420. VBISynGly105927_2897.

Phylogenomic databases

KOiK01775.
OMAiWKGGAAI.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSGLY645991:GHJ4-2766-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 8271 / FlGlyRImported.

Entry informationi

Entry nameiF0SXB6_SYNGF
AccessioniPrimary (citable) accession number: F0SXB6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 24, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.