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F0RKC6

- F0RKC6_DEIPM

UniProt

F0RKC6 - F0RKC6_DEIPM

Protein

Serine hydroxymethyltransferase

Gene

glyA

Organism
Deinococcus proteolyticus (strain ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM Ac-1939 / CCM 2703)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei32 – 321Pyridoxal phosphateUniRule annotation
    Binding sitei52 – 521Pyridoxal phosphateUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Binding sitei62 – 621Pyridoxal phosphateUniRule annotation
    Binding sitei96 – 961Pyridoxal phosphateUniRule annotation
    Binding sitei118 – 1181Substrate; via carbonyl oxygenUniRule annotation
    Binding sitei173 – 1731Pyridoxal phosphateUniRule annotation
    Binding sitei201 – 2011Pyridoxal phosphateUniRule annotation
    Binding sitei226 – 2261Pyridoxal phosphateUniRule annotation
    Binding sitei233 – 2331Pyridoxal phosphateUniRule annotation
    Binding sitei259 – 2591Pyridoxal phosphate; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei359 – 3591Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
    2. methyltransferase activity Source: UniProtKB-KW
    3. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesisUniRule annotation, One-carbon metabolismUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciDPRO693977:GCFA-1611-MONOMER.
    UniPathwayiUPA00193.
    UPA00288; UER01023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.1UniRule annotation)
    Short name:
    SHMTUniRule annotation
    Short name:
    Serine methylaseUniRule annotation
    Gene namesi
    Name:glyAUniRule annotation
    Ordered Locus Names:Deipr_1567Imported
    OrganismiDeinococcus proteolyticus (strain ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM Ac-1939 / CCM 2703)Imported
    Taxonomic identifieri693977 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000007718: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei227 – 2271N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SHMT family.UniRule annotation

    Phylogenomic databases

    KOiK00600.
    OMAiHLMLVDV.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00051. SHMT.
    InterProiIPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view]
    PANTHERiPTHR11680. PTHR11680. 1 hit.
    PfamiPF00464. SHMT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000412. SHMT. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00096. SHMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0RKC6-1 [UniParc]FASTAAdd to Basket

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    MTTPLEQKDQ TVFDLIQQEA ERQRLGLELI ASENFTSAAV REAVGSIATN    50
    KYAEGYPGKR WYGGCEVIDK IEQLAIDRAC ELFGAAWANV QPHSGSSANI 100
    AVYAALLEEG DTVMGMDLSH GGHLTHGSPV NFSGKRFNIV GYRVDEETER 150
    LDMEAVRALA LEHRPKMIIA GASAYSRQID FAAFRAIADE VGAYLFADIA 200
    HIAGLVAAGL HPNPVPHAHI VATTTHKTLR GPRSGLLLSN DPELGAKIDR 250
    AIFPGHQGGP LEHVIAGKAV AFGEALQPAF KDYAAQIIKN AQALAAAMEA 300
    RGYRIVTGGT DNHMFLADLR PQGLNGTKAT QALDANFITI SKSTLPFDTE 350
    KILHGGGIRI GTPAVTTRGM KESDMDRVAD LIDRALKGED VKEEVHAFAG 400
    QFPMP 405
    Length:405
    Mass (Da):43,512
    Last modified:May 3, 2011 - v1
    Checksum:i50F1AB5C003E8F83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002536 Genomic DNA. Translation: ADY26705.1.
    RefSeqiWP_013615313.1. NC_015161.1.
    YP_004256322.1. NC_015161.1.

    Genome annotation databases

    EnsemblBacteriaiADY26705; ADY26705; Deipr_1567.
    GeneIDi10257062.
    KEGGidpt:Deipr_1567.
    PATRICi46930958. VBIDeiPro159979_1558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002536 Genomic DNA. Translation: ADY26705.1 .
    RefSeqi WP_013615313.1. NC_015161.1.
    YP_004256322.1. NC_015161.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADY26705 ; ADY26705 ; Deipr_1567 .
    GeneIDi 10257062.
    KEGGi dpt:Deipr_1567.
    PATRICi 46930958. VBIDeiPro159979_1558.

    Phylogenomic databases

    KOi K00600.
    OMAi HLMLVDV.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    UPA00288 ; UER01023 .
    BioCyci DPRO693977:GCFA-1611-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00051. SHMT.
    InterProi IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view ]
    PANTHERi PTHR11680. PTHR11680. 1 hit.
    Pfami PF00464. SHMT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000412. SHMT. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00096. SHMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM Ac-1939 / CCM 2703Imported.

    Entry informationi

    Entry nameiF0RKC6_DEIPM
    AccessioniPrimary (citable) accession number: F0RKC6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3