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F0RKC6

- F0RKC6_DEIPM

UniProt

F0RKC6 - F0RKC6_DEIPM

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Protein

Serine hydroxymethyltransferase

Gene

glyA

Organism
Deinococcus proteolyticus (strain ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM Ac-1939 / CCM 2703)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321Pyridoxal phosphateUniRule annotation
Binding sitei52 – 521Pyridoxal phosphateUniRule annotation
Binding sitei54 – 541SubstrateUniRule annotation
Binding sitei62 – 621Pyridoxal phosphateUniRule annotation
Binding sitei96 – 961Pyridoxal phosphateUniRule annotation
Binding sitei118 – 1181Substrate; via carbonyl oxygenUniRule annotation
Binding sitei173 – 1731Pyridoxal phosphateUniRule annotation
Binding sitei201 – 2011Pyridoxal phosphateUniRule annotation
Binding sitei226 – 2261Pyridoxal phosphateUniRule annotation
Binding sitei233 – 2331Pyridoxal phosphateUniRule annotation
Binding sitei259 – 2591Pyridoxal phosphate; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei359 – 3591Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
  2. methyltransferase activity Source: UniProtKB-KW
  3. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesisUniRule annotation, One-carbon metabolismUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciDPRO693977:GCFA-1611-MONOMER.
UniPathwayiUPA00193.
UPA00288; UER01023.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.1UniRule annotation)
Short name:
SHMTUniRule annotation
Short name:
Serine methylaseUniRule annotation
Gene namesi
Name:glyAUniRule annotation
Ordered Locus Names:Deipr_1567Imported
OrganismiDeinococcus proteolyticus (strain ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM Ac-1939 / CCM 2703)Imported
Taxonomic identifieri693977 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000007718: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the SHMT family.UniRule annotation

Phylogenomic databases

KOiK00600.
OMAiHLMLVDV.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0RKC6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPLEQKDQ TVFDLIQQEA ERQRLGLELI ASENFTSAAV REAVGSIATN
60 70 80 90 100
KYAEGYPGKR WYGGCEVIDK IEQLAIDRAC ELFGAAWANV QPHSGSSANI
110 120 130 140 150
AVYAALLEEG DTVMGMDLSH GGHLTHGSPV NFSGKRFNIV GYRVDEETER
160 170 180 190 200
LDMEAVRALA LEHRPKMIIA GASAYSRQID FAAFRAIADE VGAYLFADIA
210 220 230 240 250
HIAGLVAAGL HPNPVPHAHI VATTTHKTLR GPRSGLLLSN DPELGAKIDR
260 270 280 290 300
AIFPGHQGGP LEHVIAGKAV AFGEALQPAF KDYAAQIIKN AQALAAAMEA
310 320 330 340 350
RGYRIVTGGT DNHMFLADLR PQGLNGTKAT QALDANFITI SKSTLPFDTE
360 370 380 390 400
KILHGGGIRI GTPAVTTRGM KESDMDRVAD LIDRALKGED VKEEVHAFAG

QFPMP
Length:405
Mass (Da):43,512
Last modified:May 3, 2011 - v1
Checksum:i50F1AB5C003E8F83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002536 Genomic DNA. Translation: ADY26705.1.
RefSeqiYP_004256322.1. NC_015161.1.

Genome annotation databases

EnsemblBacteriaiADY26705; ADY26705; Deipr_1567.
GeneIDi10257062.
KEGGidpt:Deipr_1567.
PATRICi46930958. VBIDeiPro159979_1558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002536 Genomic DNA. Translation: ADY26705.1 .
RefSeqi YP_004256322.1. NC_015161.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADY26705 ; ADY26705 ; Deipr_1567 .
GeneIDi 10257062.
KEGGi dpt:Deipr_1567.
PATRICi 46930958. VBIDeiPro159979_1558.

Phylogenomic databases

KOi K00600.
OMAi HLMLVDV.

Enzyme and pathway databases

UniPathwayi UPA00193 .
UPA00288 ; UER01023 .
BioCyci DPRO693977:GCFA-1611-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00051. SHMT.
InterProi IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view ]
PANTHERi PTHR11680. PTHR11680. 1 hit.
Pfami PF00464. SHMT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000412. SHMT. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00096. SHMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM Ac-1939 / CCM 2703Imported.

Entry informationi

Entry nameiF0RKC6_DEIPM
AccessioniPrimary (citable) accession number: F0RKC6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3