Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

Bacsa_0108

Organism
Bacteroides salanitronis (strain DSM 18170 / JCM 13567 / BL78)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBSAL667015:GHA0-205-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Bacsa_0108Imported
OrganismiBacteroides salanitronis (strain DSM 18170 / JCM 13567 / BL78)Imported
Taxonomic identifieri667015 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000007486 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF0R4N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0R4N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVQMKDGR LIVPDCVTIP YIEGDGVGAE ITPVCQKIVN EAVRAAYGGK
60 70 80 90 100
RSIEWMEVLA GGKAFAQTGE WLPQATLDVF REYLIGIKGP LTTPVGGGIR
110 120 130 140 150
SLNVALRQTL DLYVCLRPVR WFKGVVSPLK EPQKVNMHIF RENTEDIYAG
160 170 180 190 200
IEWEQGTPEA QKFYTFLHDE MGVSKVRFPE TSSFGVKPVS AEGSKRLVRS
210 220 230 240 250
AIRYALQHHQ TSVTLVHKGN IMKFTEGGFK RWGYEVAEQE FPDQTFSMNQ
260 270 280 290 300
YNQIKKDLGE ESANAALADA ANTGKVIIKD CIADAFLQNT LLKPEEYAVI
310 320 330 340 350
ATLNLNGDYI SDQLAAMVGG IGIAPGANIN YATGHAIFEA THGTAPDIAG
360 370 380 390 400
KNIVNPCSML LSSVMMLEHL GWEEAATLIT QALEKLFEAG EATNDLARFM
410 420
PNGKPLGTME FGQRVIDALS SN
Length:422
Mass (Da):46,208
Last modified:May 3, 2011 - v1
Checksum:i3CB3D1B347D28F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002530 Genomic DNA. Translation: ADY34721.1.
RefSeqiYP_004257194.1. NC_015164.1.

Genome annotation databases

EnsemblBacteriaiADY34721; ADY34721; Bacsa_0108.
KEGGibsa:Bacsa_0108.
PATRICi46876099. VBIBacSal140776_0116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002530 Genomic DNA. Translation: ADY34721.1.
RefSeqiYP_004257194.1. NC_015164.1.

3D structure databases

ProteinModelPortaliF0R4N1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADY34721; ADY34721; Bacsa_0108.
KEGGibsa:Bacsa_0108.
PATRICi46876099. VBIBacSal140776_0116.

Phylogenomic databases

KOiK00031.
OMAiFRDWGYE.

Enzyme and pathway databases

BioCyciBSAL667015:GHA0-205-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18170 / JCM 13567 / BL78Imported.

Entry informationi

Entry nameiF0R4N1_BACSH
AccessioniPrimary (citable) accession number: F0R4N1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 1, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.