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Protein

Alanine racemase

Gene

Bacsa_1763

Organism
Bacteroides salanitronis (strain DSM 18170 / JCM 13567 / BL78)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Bacsa_1763)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei493Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei591SubstrateUniRule annotation1
Active sitei718Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei767Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported, LigaseImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Bacsa_1763Imported
OrganismiBacteroides salanitronis (strain DSM 18170 / JCM 13567 / BL78)Imported
Taxonomic identifieri667015 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000007486 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei493N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi667015.Bacsa_1763.

Structurei

3D structure databases

ProteinModelPortaliF0R194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini697 – 821Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0770. LUCA.
COG0787. LUCA.
KOiK01775.
OMAiMVKAFAY.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
IPR005863. UDP-N-AcMur_synth.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR01143. murF. 1 hit.

Sequencei

Sequence statusi: Complete.

F0R194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSIEEIVS VVGATRIGER QASISWILTD SRSLCFPEET LFFALKAKRN
60 70 80 90 100
DGHKYIPELY ARGVYNFVVA EVPEEMKNCT DVNFLVVGNV LKALQRLAGK
110 120 130 140 150
HREQYQVPVI GITGSNGKTV VKEWLYQLLS PDKRIIRSPR SYNSQIGVPL
160 170 180 190 200
SVWMMDEHTE LGIFEAGISE MGEMETLEPI IRPTIGVLTN IGGAHQENFS
210 220 230 240 250
SLQDKCMEKL LLFKECDVIV YNGDNELIRD CVSKSLFTAR EIAWSMKDPE
260 270 280 290 300
RPLFIEKIEK DAAGTTIKYR YLGFFKEFRI PYIDDASIEN SLHCLAVALY
310 320 330 340 350
LMVPTEVIAE RMAHLEPVAM RLEVKEGKNG CVLINDSYNS DFASLDIALD
360 370 380 390 400
FMARRSEDKA RRRTLILSDI LETGQPGKLL YRQVAELVHS RGVDRLIGVG
410 420 430 440 450
EEISASSSRF DVKEKQFFLT TEELMASGVL ETLRNDIVLI KGARAFHFDA
460 470 480 490 500
VSDFLELKVH ETILEINLNA LVDNLNYYRN KLKPETKLMC MVKASAYGAG
510 520 530 540 550
PFEVAKTLEE HRVDYLAVAV ADEGADLRKA GITCPIVIMN PEATAFKTMF
560 570 580 590 600
AYRLEPNIYG FPILEEMIKA AEREGVSNFP IHIKIDTGMH RLGFSPHQDM
610 620 630 640 650
QRLVERLHRQ SAVIPRSVFS HLAGSDSERF DAFTRKQIET FEAAAAELQA
660 670 680 690 700
GFGVKILRHV CNTAGIERYP GAQFDMVRLG IGLYGIDPFT NHILHNVSTL
710 720 730 740 750
KTTILQIHDI PADETVGYSR KGVLYRDSRI ATIPIGYADG LNRHLGNGHA
760 770 780 790 800
YCLVNGKKAP YVGNICMDVC MIDVTDIDCK EGDKAIIFGD DLPVTVLAEA
810 820
LGTIPYEILT SVSNRVKRVY FQG
Length:823
Mass (Da):92,254
Last modified:May 3, 2011 - v1
Checksum:iC68A424FB9320380
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002530 Genomic DNA. Translation: ADY36322.1.
RefSeqiWP_013617753.1. NC_015164.1.

Genome annotation databases

EnsemblBacteriaiADY36322; ADY36322; Bacsa_1763.
KEGGibsa:Bacsa_1763.
PATRICi46879604. VBIBacSal140776_1846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002530 Genomic DNA. Translation: ADY36322.1.
RefSeqiWP_013617753.1. NC_015164.1.

3D structure databases

ProteinModelPortaliF0R194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi667015.Bacsa_1763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADY36322; ADY36322; Bacsa_1763.
KEGGibsa:Bacsa_1763.
PATRICi46879604. VBIBacSal140776_1846.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0770. LUCA.
COG0787. LUCA.
KOiK01775.
OMAiMVKAFAY.
OrthoDBiPOG091H022F.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
IPR005863. UDP-N-AcMur_synth.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
TIGR01143. murF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF0R194_BACSH
AccessioniPrimary (citable) accession number: F0R194
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: February 15, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.