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F0QHB3

- F0QHB3_ACIBD

UniProt

F0QHB3 - F0QHB3_ACIBD

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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene
lpxA, ABTW07_2294
Organism
Acinetobacter baumannii (strain TCDC-AB0715)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotationSAAS annotations

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Sulfate 1Imported
Binding sitei136 – 1361Citrate
Binding sitei142 – 1421Citrate; via amide nitrogen
Binding sitei159 – 1591Citrate
Binding sitei207 – 2071Sulfate 2Imported
Binding sitei258 – 2581Citrate

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Lipid A biosynthesisUniRule annotationSAAS annotations, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciABAU980514:GL7M-2314-MONOMER.
UniPathwayiUPA00359; UER00477.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
Short name:
UDP-N-acetylglucosamine acyltransferaseUniRule annotation
Gene namesi
Name:lpxAUniRule annotationImported
Ordered Locus Names:ABTW07_2294Imported
OrganismiAcinetobacter baumannii (strain TCDC-AB0715)Imported
Taxonomic identifieri980514 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000006390: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E6TX-ray1.80A/B/C2-262[»]
4E6UX-ray1.41A2-262[»]
ProteinModelPortaliF0QHB3.
SMRiF0QHB3. Positions 4-262.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 732Citrate binding
Regioni121 – 1244Citrate binding

Sequence similaritiesi

Keywords - Domaini

RepeatUniRule annotationSAAS annotations

Phylogenomic databases

KOiK00677.
OMAiDCQDKKY.

Family and domain databases

Gene3Di1.20.1180.10. 1 hit.
HAMAPiMF_00387. LpxA.
InterProiIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 3 hits.
[Graphical view]
PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0QHB3-1 [UniParc]FASTAAdd to Basket

« Hide

MSNHDLIHST AIIDPSAVIA SDVQIGPYCI IGPQVTIGAG TKLHSHVVVG    50
GFTRIGQNNE IFQFASVGEV CQDLKYKGEE TWLEIGNNNL IREHCSLHRG 100
TVQDNALTKI GSHNLLMVNT HIAHDCIVGD HNIFANNVGV AGHVHIGDHV 150
IVGGNSGIHQ FCKIDSYSMI GGASLILKDV PAYVMASGNP AHAFGINIEG 200
MRRKGWSKNT IQGLREAYKL IFKSGLTSVQ AIDQIKSEIL PSVPEAQLLI 250
DSLEQSERGI VR 262
Length:262
Mass (Da):28,283
Last modified:May 3, 2011 - v1
Checksum:i38E7110722B2C671
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002522 Genomic DNA. Translation: ADX92718.1.
RefSeqiYP_005799177.1. NC_017387.1.

Genome annotation databases

EnsemblBacteriaiADX92718; ADX92718; ABTW07_2294.
GeneIDi12378343.
KEGGiabd:ABTW07_2294.
PATRICi47074509. VBIAciBau182139_2362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002522 Genomic DNA. Translation: ADX92718.1 .
RefSeqi YP_005799177.1. NC_017387.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E6T X-ray 1.80 A/B/C 2-262 [» ]
4E6U X-ray 1.41 A 2-262 [» ]
ProteinModelPortali F0QHB3.
SMRi F0QHB3. Positions 4-262.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADX92718 ; ADX92718 ; ABTW07_2294 .
GeneIDi 12378343.
KEGGi abd:ABTW07_2294.
PATRICi 47074509. VBIAciBau182139_2362.

Phylogenomic databases

KOi K00677.
OMAi DCQDKKY.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00477 .
BioCyci ABAU980514:GL7M-2314-MONOMER.

Family and domain databases

Gene3Di 1.20.1180.10. 1 hit.
HAMAPi MF_00387. LpxA.
InterProi IPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 3 hits.
[Graphical view ]
PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of a dominant, multidrug-resistant Acinetobacter baumannii strain, TCDC-AB0715."
    Chen C.C., Lin Y.C., Sheng W.H., Chen Y.C., Chang S.C., Hsia K.C., Liao M.H., Li S.Y.
    J. Bacteriol. 193:2361-2362(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCDC-AB0715Imported.
  2. Chen C.-C., Hsia K.-C., Lin Y.-C., Sheng W.-H., Chen Y.-C., Chang S.-C., Liao M.-H., Li S.-Y.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TCDC-AB0715.
  3. "Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii."
    Badger J., Chie-Leon B., Logan C., Sridhar V., Sankaran B., Zwart P.H., Nienaber V.
    Acta Crystallogr. F 68:1477-1481(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) OF 2-262.

Entry informationi

Entry nameiF0QHB3_ACIBD
AccessioniPrimary (citable) accession number: F0QHB3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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