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F0QHB3 (F0QHB3_ACIBD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP-Rule MF_00387

Short name=UDP-N-acetylglucosamine acyltransferase HAMAP-Rule MF_00387
EC=2.3.1.129 HAMAP-Rule MF_00387
Gene names
Name:lpxA HAMAP-Rule MF_00387 EMBL ADX92718.1
Ordered Locus Names:ABTW07_2294 EMBL ADX92718.1
OrganismAcinetobacter baumannii (strain TCDC-AB0715) [Complete proteome] [HAMAP] EMBL ADX92718.1
Taxonomic identifier980514 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00387 SAAS SAAS029098

Catalytic activity

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine. HAMAP-Rule MF_00387 SAAS SAAS029098

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP-Rule MF_00387 SAAS SAAS029098

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00387 SAAS SAAS029098

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00387 SAAS SAAS029098.

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP-Rule MF_00387

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region72 – 732Citrate binding
Region121 – 1244Citrate binding

Sites

Binding site421Sulfate 1 PDB 4E6U
Binding site1361Citrate
Binding site1421Citrate; via amide nitrogen
Binding site1591Citrate
Binding site2071Sulfate 2 PDB 4E6U
Binding site2581Citrate

Sequences

Sequence LengthMass (Da)Tools
F0QHB3 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 38E7110722B2C671

FASTA26228,283
        10         20         30         40         50         60 
MSNHDLIHST AIIDPSAVIA SDVQIGPYCI IGPQVTIGAG TKLHSHVVVG GFTRIGQNNE 

        70         80         90        100        110        120 
IFQFASVGEV CQDLKYKGEE TWLEIGNNNL IREHCSLHRG TVQDNALTKI GSHNLLMVNT 

       130        140        150        160        170        180 
HIAHDCIVGD HNIFANNVGV AGHVHIGDHV IVGGNSGIHQ FCKIDSYSMI GGASLILKDV 

       190        200        210        220        230        240 
PAYVMASGNP AHAFGINIEG MRRKGWSKNT IQGLREAYKL IFKSGLTSVQ AIDQIKSEIL 

       250        260 
PSVPEAQLLI DSLEQSERGI VR 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of a dominant, multidrug-resistant Acinetobacter baumannii strain, TCDC-AB0715."
Chen C.C., Lin Y.C., Sheng W.H., Chen Y.C., Chang S.C., Hsia K.C., Liao M.H., Li S.Y.
J. Bacteriol. 193:2361-2362(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TCDC-AB0715 EMBL ADX92718.1.
[2]Chen C.-C., Hsia K.-C., Lin Y.-C., Sheng W.-H., Chen Y.-C., Chang S.-C., Liao M.-H., Li S.-Y.
Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: TCDC-AB0715.
[3]"Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii."
Badger J., Chie-Leon B., Logan C., Sridhar V., Sankaran B., Zwart P.H., Nienaber V.
Acta Crystallogr. F 68:1477-1481(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) OF 2-262 IN COMPLEX WITH CITRATE AND SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002522 Genomic DNA. Translation: ADX92718.1.
RefSeqYP_005799177.1. NC_017387.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4E6TX-ray1.80A/B/C2-262[»]
4E6UX-ray1.41A2-262[»]
ProteinModelPortalF0QHB3.
SMRF0QHB3. Positions 4-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADX92718; ADX92718; ABTW07_2294.
GeneID12378343.
KEGGabd:ABTW07_2294.
PATRIC47074509. VBIAciBau182139_2362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00677.
OMADCQDKKY.

Enzyme and pathway databases

BioCycABAU980514:GL7M-2314-MONOMER.
UniPathwayUPA00359; UER00477.

Family and domain databases

Gene3D1.20.1180.10. 1 hit.
HAMAPMF_00387. LpxA.
InterProIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 3 hits.
[Graphical view]
PIRSFPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR01852. lipid_A_lpxA. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0QHB3_ACIBD
AccessionPrimary (citable) accession number: F0QHB3
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)