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F0QHB3

- F0QHB3_ACIBD

UniProt

F0QHB3 - F0QHB3_ACIBD

Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Acinetobacter baumannii (strain TCDC-AB0715)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotationSAAS annotation

    Catalytic activityi

    (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Sulfate 1Imported
    Binding sitei136 – 1361Citrate
    Binding sitei142 – 1421Citrate; via amide nitrogen
    Binding sitei159 – 1591Citrate
    Binding sitei207 – 2071Sulfate 2Imported
    Binding sitei258 – 2581Citrate

    GO - Molecular functioni

    1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Lipid A biosynthesisUniRule annotationSAAS annotation, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciABAU980514:GL7M-2314-MONOMER.
    UniPathwayiUPA00359; UER00477.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
    Short name:
    UDP-N-acetylglucosamine acyltransferaseUniRule annotation
    Gene namesi
    Name:lpxAUniRule annotationImported
    Ordered Locus Names:ABTW07_2294Imported
    OrganismiAcinetobacter baumannii (strain TCDC-AB0715)Imported
    Taxonomic identifieri980514 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000006390: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E6TX-ray1.80A/B/C2-262[»]
    4E6UX-ray1.41A2-262[»]
    ProteinModelPortaliF0QHB3.
    SMRiF0QHB3. Positions 4-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni72 – 732Citrate binding
    Regioni121 – 1244Citrate binding

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

    Keywords - Domaini

    RepeatUniRule annotationSAAS annotation

    Phylogenomic databases

    KOiK00677.
    OMAiDCQDKKY.

    Family and domain databases

    Gene3Di1.20.1180.10. 1 hit.
    HAMAPiMF_00387. LpxA.
    InterProiIPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 3 hits.
    [Graphical view]
    PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0QHB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNHDLIHST AIIDPSAVIA SDVQIGPYCI IGPQVTIGAG TKLHSHVVVG    50
    GFTRIGQNNE IFQFASVGEV CQDLKYKGEE TWLEIGNNNL IREHCSLHRG 100
    TVQDNALTKI GSHNLLMVNT HIAHDCIVGD HNIFANNVGV AGHVHIGDHV 150
    IVGGNSGIHQ FCKIDSYSMI GGASLILKDV PAYVMASGNP AHAFGINIEG 200
    MRRKGWSKNT IQGLREAYKL IFKSGLTSVQ AIDQIKSEIL PSVPEAQLLI 250
    DSLEQSERGI VR 262
    Length:262
    Mass (Da):28,283
    Last modified:May 3, 2011 - v1
    Checksum:i38E7110722B2C671
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002522 Genomic DNA. Translation: ADX92718.1.
    RefSeqiYP_005799177.1. NC_017387.1.

    Genome annotation databases

    EnsemblBacteriaiADX92718; ADX92718; ABTW07_2294.
    GeneIDi12378343.
    KEGGiabd:ABTW07_2294.
    PATRICi47074509. VBIAciBau182139_2362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002522 Genomic DNA. Translation: ADX92718.1 .
    RefSeqi YP_005799177.1. NC_017387.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E6T X-ray 1.80 A/B/C 2-262 [» ]
    4E6U X-ray 1.41 A 2-262 [» ]
    ProteinModelPortali F0QHB3.
    SMRi F0QHB3. Positions 4-262.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADX92718 ; ADX92718 ; ABTW07_2294 .
    GeneIDi 12378343.
    KEGGi abd:ABTW07_2294.
    PATRICi 47074509. VBIAciBau182139_2362.

    Phylogenomic databases

    KOi K00677.
    OMAi DCQDKKY.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00477 .
    BioCyci ABAU980514:GL7M-2314-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1180.10. 1 hit.
    HAMAPi MF_00387. LpxA.
    InterProi IPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a dominant multidrug-resistant Acinetobacter baumannii strain TCDC-AB0715."
      Chen C.C., Lin Y.C., Sheng W.H., Chen Y.C., Chang S.C., Hsia K.C., Liao M.H., Li S.Y.
      J. Bacteriol. 193:2361-2362(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCDC-AB0715Imported.
    2. Chen C.-C., Hsia K.-C., Lin Y.-C., Sheng W.-H., Chen Y.-C., Chang S.-C., Liao M.-H., Li S.-Y.
      Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: TCDC-AB0715.
    3. "Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii."
      Badger J., Chie-Leon B., Logan C., Sridhar V., Sankaran B., Zwart P.H., Nienaber V.
      Acta Crystallogr. F 68:1477-1481(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) OF 2-262.

    Entry informationi

    Entry nameiF0QHB3_ACIBD
    AccessioniPrimary (citable) accession number: F0QHB3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3