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F0QCU6

- F0QCU6_ACIAP

UniProt

F0QCU6 - F0QCU6_ACIAP

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Protein

Kynureninase

Gene
kynU, Acav_1167
Organism
Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei98 – 981Pyridoxal phosphate By similarityUniRule annotation
Binding sitei169 – 1691Pyridoxal phosphate By similarityUniRule annotation
Binding sitei198 – 1981Pyridoxal phosphate By similarityUniRule annotation
Binding sitei201 – 2011Pyridoxal phosphate By similarityUniRule annotation
Binding sitei223 – 2231Pyridoxal phosphate By similarityUniRule annotation
Binding sitei253 – 2531Pyridoxal phosphate By similarityUniRule annotation
Binding sitei279 – 2791Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciAAVE643561:GHRD-1171-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Acav_1167Imported
OrganismiAcidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011)Imported
Taxonomic identifieri643561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000002482: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei224 – 2241N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF0QCU6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1324Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.
OMAiVWDLAHS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

F0QCU6-1 [UniParc]FASTAAdd to Basket

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MTTLDDCRAL DAHDPLRPLR GHFQLPDGVI YLDGNSLGVL PKAAPARIAE    50
VVAQEWGTDL IRSWNSASWF DLPQRLGNQL APLIGAGAGE VVCTDSTSIN 100
LYKVLSAALN IAREDAPARR RIVSERSNFP TDLYIAEGLC RERGLELVLV 150
EPEEIPAALT GDVAVLMLTH VNYRTGAMHD MAAVTAAAHA QGILCVWDLA 200
HSAGAVPVDL RGAGADFSIG CGYKYLNGGP GAPAFVWVHP RHADRFWQPL 250
SGWWGHAAPF AFTPDYQPAP GISRYLCGTQ PIISLSALQC GLDVFTAAQP 300
LGGMQALRAK SLALTDLFIR LVEERCAGHG LGLATPREHA RRGSQVCLTR 350
DEGQGVDGQG SGAYAIVQAL IARGVIGDFR KGDGGQGPHK DILRFGLTPL 400
YLGFEDVWNA VEHLRAVLDG GEWRRPEFNQ QHAVT 435
Length:435
Mass (Da):46,825
Last modified:May 3, 2011 - v1
Checksum:iF2F3041F3030DE02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002521 Genomic DNA. Translation: ADX45089.1.
RefSeqiWP_013593628.1. NC_015138.1.
YP_004233656.1. NC_015138.1.

Genome annotation databases

EnsemblBacteriaiADX45089; ADX45089; Acav_1167.
GeneIDi10306072.
KEGGiaaa:Acav_1167.
PATRICi46836967. VBIAciAve68977_1186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002521 Genomic DNA. Translation: ADX45089.1 .
RefSeqi WP_013593628.1. NC_015138.1.
YP_004233656.1. NC_015138.1.

3D structure databases

ProteinModelPortali F0QCU6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADX45089 ; ADX45089 ; Acav_1167 .
GeneIDi 10306072.
KEGGi aaa:Acav_1167.
PATRICi 46836967. VBIAciAve68977_1186.

Phylogenomic databases

KOi K01556.
OMAi VWDLAHS.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci AAVE643561:GHRD-1171-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Acidovorax avenae subsp. avenae ATCC 19860."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Gordon S., Woyke T.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011.

Entry informationi

Entry nameiF0QCU6_ACIAP
AccessioniPrimary (citable) accession number: F0QCU6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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