ID   F0Q8E2_PARA1            Unreviewed;       324 AA.
AC   F0Q8E2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=Homoserine kinase {ECO:0000256|HAMAP-Rule:MF_00301};
DE            Short=HK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000256|HAMAP-Rule:MF_00301};
GN   Name=thrB {ECO:0000256|HAMAP-Rule:MF_00301};
GN   OrderedLocusNames=Acav_3238 {ECO:0000313|EMBL:ADX47140.1};
OS   Paracidovorax avenae (strain ATCC 19860 / DSM 7227 / CCUG 15838 / JCM 20985
OS   / LMG 2117 / NCPPB 1011) (Acidovorax avenae).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Paracidovorax.
OX   NCBI_TaxID=643561 {ECO:0000313|EMBL:ADX47140.1, ECO:0000313|Proteomes:UP000002482};
RN   [1] {ECO:0000313|Proteomes:UP000002482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19860 / DSM 7227 / CCUG 15838 / JCM 20985 / LMG 2117 /
RC   NCPPB 1011 {ECO:0000313|Proteomes:UP000002482};
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Chertkov O., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Gordon S., Woyke T.;
RT   "Complete sequence of Acidovorax avenae subsp. avenae ATCC 19860.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39; Evidence={ECO:0000256|HAMAP-Rule:MF_00301};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 4/5. {ECO:0000256|HAMAP-Rule:MF_00301}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00301}.
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DR   EMBL; CP002521; ADX47140.1; -; Genomic_DNA.
DR   RefSeq; WP_013595628.1; NC_015138.1.
DR   AlphaFoldDB; F0Q8E2; -.
DR   GeneID; 34238973; -.
DR   KEGG; aaa:Acav_3238; -.
DR   HOGENOM; CLU_053300_0_0_4; -.
DR   OrthoDB; 9777460at2; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000002482; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   NCBIfam; TIGR00938; thrB_alt; 1.
DR   PANTHER; PTHR21064:SF6; APH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605, ECO:0000256|HAMAP-
KW   Rule:MF_00301}; ATP-binding {ECO:0000256|HAMAP-Rule:MF_00301};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000313|EMBL:ADX47140.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00301};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002482};
KW   Threonine biosynthesis {ECO:0000256|ARBA:ARBA00022697, ECO:0000256|HAMAP-
KW   Rule:MF_00301};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000313|EMBL:ADX47140.1}.
FT   DOMAIN          27..258
FT                   /note="Aminoglycoside phosphotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF01636"
SQ   SEQUENCE   324 AA;  36138 MW;  480027D2CBA07CF9 CRC64;
     MAVFTEVSKK EARDLLRRLQ LGTLESLRGI EGGIENTNYF LTSDQGEYVL TLFERLTAEQ
     LPFYLHLMKH LAQAGMPVPD PRGDRHGNIL HTVAGKPAAV VNKLPGRSQL APEPVHCAAV
     GGMLARMHLA GRDYERRQPN LRGLAWWNET VPVVLPHIGE SQRTLLRSEL AYQNHVAASA
     GYAALPRGPV HADLFRDNAM FDGEVLTGFF DFYFAGVDTW LFDLAVCLND WCIDWPTGLH
     APGRATAMLD AYQAVRPLSA DERALLPAML RAGALRFWIS RLWDFHLPRE ASLLTPHDPT
     HFERVLRGRI AQPLHVRAGG GFAE
//