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Protein

Homoserine kinase

Gene

thrB

Organism
Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Acav_2806)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Acav_0021), Homoserine dehydrogenase (Acav_1256)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotationSAAS annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Acav_3238Imported
OrganismiAcidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011)Imported
Taxonomic identifieri643561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000002482 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 257APHInterPro annotationAdd BLAST231

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK02204.
OMAiAGALRFW.
OrthoDBiPOG091H0G0T.

Family and domain databases

CDDicd05153. HomoserineK_II. 1 hit.
HAMAPiMF_00301. Homoser_kinase_2. 1 hit.
InterProiView protein in InterPro
IPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_II.
IPR011009. Kinase-like_dom.
PfamiView protein in Pfam
PF01636. APH. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

Sequencei

Sequence statusi: Complete.

F0Q8E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFTEVSKK EARDLLRRLQ LGTLESLRGI EGGIENTNYF LTSDQGEYVL
60 70 80 90 100
TLFERLTAEQ LPFYLHLMKH LAQAGMPVPD PRGDRHGNIL HTVAGKPAAV
110 120 130 140 150
VNKLPGRSQL APEPVHCAAV GGMLARMHLA GRDYERRQPN LRGLAWWNET
160 170 180 190 200
VPVVLPHIGE SQRTLLRSEL AYQNHVAASA GYAALPRGPV HADLFRDNAM
210 220 230 240 250
FDGEVLTGFF DFYFAGVDTW LFDLAVCLND WCIDWPTGLH APGRATAMLD
260 270 280 290 300
AYQAVRPLSA DERALLPAML RAGALRFWIS RLWDFHLPRE ASLLTPHDPT
310 320
HFERVLRGRI AQPLHVRAGG GFAE
Length:324
Mass (Da):36,138
Last modified:May 3, 2011 - v1
Checksum:i480027D2CBA07CF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002521 Genomic DNA. Translation: ADX47140.1.
RefSeqiWP_013595628.1. NC_015138.1.

Genome annotation databases

EnsemblBacteriaiADX47140; ADX47140; Acav_3238.
KEGGiaaa:Acav_3238.

Similar proteinsi

Entry informationi

Entry nameiF0Q8E2_ACIAP
AccessioniPrimary (citable) accession number: F0Q8E2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 27, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported