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F0Q7Z3 (F0Q7Z3_ACIAP) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Acav_0754 EMBL ADX44677.1
OrganismAcidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011) [Complete proteome] [HAMAP] EMBL ADX44677.1
Taxonomic identifier643561 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain115 – 315201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding141 – 19656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2681Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F0Q7Z3 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 3B98826DF50D901F

FASTA33536,028
        10         20         30         40         50         60 
MTAVDLKDSE IDVRALGKVA VLMGGDSAER EVSLMSGGGV LQALRARGVD AHAFDPSQSD 

        70         80         90        100        110        120 
LSELKSHGYA RCFIALHGRH GEDGTVQGAL ELLGIPYTGP GVMASSIAMD KIMTKRIWRF 

       130        140        150        160        170        180 
EGLPTPDWRL VSSAAETAQA LKDLGSPMIV KPSREGSTIG LTKVTSPGQC EQAYRLASRY 

       190        200        210        220        230        240 
DPEVLCEQFI DGEETTCPVL GQGAGAHALP VIRIVAPEGN YDYQNKYFTD VTQYHCPSGL 

       250        260        270        280        290        300 
PEQEEREIRR LVVEAFRTLQ CRGWARADIM IRASDRKPFL LEINTSPGMT GHSLVPMSAR 

       310        320        330 
AMGVSYEELC LRILAGASLD ARQGQAGAAG HPGAA 

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References

[1]"Complete sequence of Acidovorax avenae subsp. avenae ATCC 19860."
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Gordon S., Woyke T.
Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002521 Genomic DNA. Translation: ADX44677.1.
RefSeqYP_004233244.1. NC_015138.1.

3D structure databases

ProteinModelPortalF0Q7Z3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADX44677; ADX44677; Acav_0754.
GeneID10305658.
KEGGaaa:Acav_0754.
PATRIC46836110. VBIAciAve68977_0764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAMEFCVLF.

Enzyme and pathway databases

BioCycAAVE643561:GHRD-757-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0Q7Z3_ACIAP
AccessionPrimary (citable) accession number: F0Q7Z3
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: February 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)