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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Weevi_1186

Organism
Weeksella virosa (strain ATCC 43766 / DSM 16922 / JCM 21250 / NBRC 16016 / NCTC 11634 / CL345/78)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451SubstrateUniRule annotation
Sitei255 – 2551Critical for catalysisUniRule annotation
Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei545 – 5451SubstrateUniRule annotation
Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciWVIR865938:GHXX-1227-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Weevi_1186Imported
OrganismiWeeksella virosa (strain ATCC 43766 / DSM 16922 / JCM 21250 / NBRC 16016 / NCTC 11634 / CL345/78)Imported
Taxonomic identifieri865938 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeWeeksella
ProteomesiUP000008641 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi865938.Weevi_1186.

Structurei

3D structure databases

ProteinModelPortaliF0P2Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1398Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiRDSGKMW.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F0P2Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSKIFYTL TDEAPMLATH SFLPIVKAFT KSADVEIAVP DISLAGRILA
60 70 80 90 100
NFSSYLKDDQ KVADALIELG ELATKPEANI IKLPNISASI PQLEGAIAEL
110 120 130 140 150
QAKGYAVPNY PAEPKNEEEK AIKAQYAKVL GSAVNPVLRE GNSDRRAPKA
160 170 180 190 200
VKNYAKANPH RMGDWTKDSQ TDVAHMDHGD FYGTETSTTI ENATKFRIVF
210 220 230 240 250
KSIDGKEEVL KDFAPLQAGE VIDSSVMNIN ALKEFVKSAI GEAEKRNVLL
260 270 280 290 300
SAHLKATMMK ISDPIIFGAI VETYFSDVFA KYAETFKSLD ISPNNGLAGL
310 320 330 340 350
FEKIKGNPQE EEIKADIAKT IENGPRLAMV NSDKGITNFH VPSDVIVDAS
360 370 380 390 400
MAALVRGGGK MWNKDGNEED TIAIIPDRSY AGFYQSVIDD MKANGKLDPT
410 420 430 440 450
TMGSVPNVGL MAQKAEEYGS HDKTFQAQAN GTIEVQSEDG AVLLSQKVEK
460 470 480 490 500
GDIFRMCQTK DAPIQDWVKL AVNRSRLSET PAIFWLDKER AHDREIIKKV
510 520 530 540 550
EKYLGDHDTK GLDIRIMDVK DAMTETLKRA REGKDTISVS GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSIVPLM NGGGLFETGA GGSAPKHVQQ FVEEGYLRWD
610 620 630 640 650
SLGEFLALQA SLEHLAQTQN NPKAQILADA LDQANAEFLS TNKSPGRKLG
660 670 680 690 700
TIDNRGSHFY LAMYWAKALA EQTKDEELAK LFAPIAAKMK EQEDKINEEL
710 720 730
IGAQGKPQDI GGYYKTDFSK TDAAMRPSAT LNEIIQSI
Length:738
Mass (Da):80,971
Last modified:May 3, 2011 - v1
Checksum:i65383B3A4088D40B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002455 Genomic DNA. Translation: ADX67895.1.
RefSeqiWP_013598285.1. NC_015144.1.

Genome annotation databases

EnsemblBacteriaiADX67895; ADX67895; Weevi_1186.
KEGGiwvi:Weevi_1186.
PATRICi47059768. VBIWeeVir165365_1203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002455 Genomic DNA. Translation: ADX67895.1.
RefSeqiWP_013598285.1. NC_015144.1.

3D structure databases

ProteinModelPortaliF0P2Y3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi865938.Weevi_1186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADX67895; ADX67895; Weevi_1186.
KEGGiwvi:Weevi_1186.
PATRICi47059768. VBIWeeVir165365_1203.

Phylogenomic databases

KOiK00031.
OMAiRDSGKMW.

Enzyme and pathway databases

BioCyciWVIR865938:GHXX-1227-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43766 / DSM 16922 / JCM 21250 / NBRC 16016 / NCTC 11634 / CL345/78Imported.

Entry informationi

Entry nameiF0P2Y3_WEEVC
AccessioniPrimary (citable) accession number: F0P2Y3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 22, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.