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F0NQG4

- F0NQG4_SULIH

UniProt

F0NQG4 - F0NQG4_SULIH

Protein

Acetylornithine/acetyl-lysine aminotransferase

Gene

argD

Organism
Sulfolobus islandicus (strain HVE10/4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

    Catalytic activityi

    N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.UniRule annotation
    N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei137 – 1371Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
    Binding sitei140 – 1401N2-acetyl-L-ornithineUniRule annotation
    Binding sitei300 – 3001Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciSISL930943:GLLW-2194-MONOMER.
    UniPathwayiUPA00033; UER00038.
    UPA00068; UER00109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylornithine/acetyl-lysine aminotransferaseUniRule annotation (EC:2.6.1.-UniRule annotation, EC:2.6.1.11UniRule annotation)
    Short name:
    ACOATUniRule annotation
    Gene namesi
    Name:argDUniRule annotation
    Synonyms:lysJUniRule annotation
    Ordered Locus Names:SiH_2095Imported
    OrganismiSulfolobus islandicus (strain HVE10/4)Imported
    Taxonomic identifieri930943 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000006395: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 1112Pyridoxal phosphate bindingUniRule annotation
    Regioni243 – 2464Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

    Phylogenomic databases

    KOiK00823.
    OMAiQHASTFG.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_01107. ArgD_aminotrans_3.
    InterProiIPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0NQG4-1 [UniParc]FASTAAdd to Basket

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    MSKKVDELVK EDQEYLMQSF RRWYPFAIDR GSGAIVYDIE GKEYIDFNAG    50
    IGVVALGHKN EKIISAVKEQ MEKFFHYSLT DFYYEIAVEV AKRLSSLMPF 100
    SAKVFYTNSG TESVEAAIKI ARGHTRRQWI IGFLNSFHGR TLGSLAFTSS 150
    KAIQRKSFSP LLPSTYLIPY PDKRDPLCKE DCTEALLGFI EDWIFKKVVD 200
    PNEIAAFIAE PIQGEGGVIV PPKDFFYKLN NLLKKFGILL ILDEVQTGIG 250
    RTGKMFAFEH FNVTPDLVCL AKALGGGLPL GAVIGRKEIM DLPPGSHANT 300
    FGGNPLALAA AKVILEEVPK LLDHVSSIGK KIIEELKDTR SPYLYDVRGL 350
    GLLIGAELRK DNKPFVEGLE KVLYNSFRRG VLAIGAGESV VRIEPPLIIE 400
    EDLALKGTRI LIEEIEKL 418
    Length:418
    Mass (Da):46,575
    Last modified:May 3, 2011 - v1
    Checksum:i818CE94F75A644F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002426 Genomic DNA. Translation: ADX83439.1.
    RefSeqiWP_014512956.1. NC_017275.1.
    YP_005646653.1. NC_017275.1.

    Genome annotation databases

    EnsemblBacteriaiADX83439; ADX83439; SiH_2095.
    GeneIDi12416214.
    KEGGisih:SiH_2095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002426 Genomic DNA. Translation: ADX83439.1 .
    RefSeqi WP_014512956.1. NC_017275.1.
    YP_005646653.1. NC_017275.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADX83439 ; ADX83439 ; SiH_2095 .
    GeneIDi 12416214.
    KEGGi sih:SiH_2095.

    Phylogenomic databases

    KOi K00823.
    OMAi QHASTFG.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00038 .
    UPA00068 ; UER00109 .
    BioCyci SISL930943:GLLW-2194-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_01107. ArgD_aminotrans_3.
    InterProi IPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analyses of icelandic strains of Sulfolobus islandicus, model organisms for genetic and virus-host interaction studies."
      Guo L., Brugger K., Liu C., Shah S.A., Zheng H., Zhu Y., Wang S., Lillestol R.K., Chen L., Frank J., Prangishvili D., Paulin L., She Q., Huang L., Garrett R.A.
      J. Bacteriol. 193:1672-1680(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HVE10/4Imported.

    Entry informationi

    Entry nameiF0NQG4_SULIH
    AccessioniPrimary (citable) accession number: F0NQG4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3