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Protein

Acetylornithine/acetyl-lysine aminotransferase

Gene

argD

Organism
Sulfolobus islandicus (strain HVE10/4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in both the arginine and lysine biosynthetic pathways.UniRule annotation

Catalytic activityi

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.UniRule annotation
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathway:iL-arginine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Acetylglutamate/acetylaminoadipate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase (argC)
  4. Acetylornithine/acetyl-lysine aminotransferase (argD), Acetylornithine/acetyl-lysine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Pathway:iL-lysine biosynthesis via AAA pathway

This protein is involved in step 4 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route).UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Acetylglutamate/acetylaminoadipate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase (argC)
  4. Acetylornithine/acetyl-lysine aminotransferase (argD), Acetylornithine/acetyl-lysine aminotransferase (argD)
  5. N-acetyl-lysine deacetylase (lysK)
This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei140 – 1401N2-acetyl-L-ornithineUniRule annotation
Binding sitei300 – 3001Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSISL930943:GLLW-2194-MONOMER.
UniPathwayiUPA00033; UER00038.
UPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine/acetyl-lysine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Synonyms:lysJUniRule annotation
Ordered Locus Names:SiH_2095Imported
OrganismiSulfolobus islandicus (strain HVE10/4)Imported
Taxonomic identifieri930943 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000006395 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF0NQG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1112Pyridoxal phosphate bindingUniRule annotation
Regioni243 – 2464Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

KOiK00823.
OMAiLIVQKTH.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0NQG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKVDELVK EDQEYLMQSF RRWYPFAIDR GSGAIVYDIE GKEYIDFNAG
60 70 80 90 100
IGVVALGHKN EKIISAVKEQ MEKFFHYSLT DFYYEIAVEV AKRLSSLMPF
110 120 130 140 150
SAKVFYTNSG TESVEAAIKI ARGHTRRQWI IGFLNSFHGR TLGSLAFTSS
160 170 180 190 200
KAIQRKSFSP LLPSTYLIPY PDKRDPLCKE DCTEALLGFI EDWIFKKVVD
210 220 230 240 250
PNEIAAFIAE PIQGEGGVIV PPKDFFYKLN NLLKKFGILL ILDEVQTGIG
260 270 280 290 300
RTGKMFAFEH FNVTPDLVCL AKALGGGLPL GAVIGRKEIM DLPPGSHANT
310 320 330 340 350
FGGNPLALAA AKVILEEVPK LLDHVSSIGK KIIEELKDTR SPYLYDVRGL
360 370 380 390 400
GLLIGAELRK DNKPFVEGLE KVLYNSFRRG VLAIGAGESV VRIEPPLIIE
410
EDLALKGTRI LIEEIEKL
Length:418
Mass (Da):46,575
Last modified:May 3, 2011 - v1
Checksum:i818CE94F75A644F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002426 Genomic DNA. Translation: ADX83439.1.
RefSeqiWP_014512956.1. NC_017275.1.
YP_005646653.1. NC_017275.1.

Genome annotation databases

EnsemblBacteriaiADX83439; ADX83439; SiH_2095.
GeneIDi12416214.
KEGGisih:SiH_2095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002426 Genomic DNA. Translation: ADX83439.1.
RefSeqiWP_014512956.1. NC_017275.1.
YP_005646653.1. NC_017275.1.

3D structure databases

ProteinModelPortaliF0NQG4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADX83439; ADX83439; SiH_2095.
GeneIDi12416214.
KEGGisih:SiH_2095.

Phylogenomic databases

KOiK00823.
OMAiLIVQKTH.

Enzyme and pathway databases

UniPathwayiUPA00033; UER00038.
UPA00068; UER00109.
BioCyciSISL930943:GLLW-2194-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome analyses of icelandic strains of Sulfolobus islandicus, model organisms for genetic and virus-host interaction studies."
    Guo L., Brugger K., Liu C., Shah S.A., Zheng H., Zhu Y., Wang S., Lillestol R.K., Chen L., Frank J., Prangishvili D., Paulin L., She Q., Huang L., Garrett R.A.
    J. Bacteriol. 193:1672-1680(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HVE10/4Imported.

Entry informationi

Entry nameiF0NQG4_SULIH
AccessioniPrimary (citable) accession number: F0NQG4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 22, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.