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F0NQG4

- F0NQG4_SULIH

UniProt

F0NQG4 - F0NQG4_SULIH

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Protein
Acetylornithine/acetyl-lysine aminotransferase
Gene
argD, lysJ, SiH_2095
Organism
Sulfolobus islandicus (strain HVE10/4)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in both the arginine and lysine biosynthetic pathways By similarity.UniRule annotation

Catalytic activityi

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.UniRule annotation
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371Pyridoxal phosphate; via carbonyl oxygen By similarityUniRule annotation
Binding sitei140 – 1401N2-acetyl-L-ornithine By similarityUniRule annotation
Binding sitei300 – 3001Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSISL930943:GLLW-2194-MONOMER.
UniPathwayiUPA00033; UER00038.
UPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine/acetyl-lysine aminotransferaseUniRule annotation (EC:2.6.1.-UniRule annotation, EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Synonyms:lysJUniRule annotation
Ordered Locus Names:SiH_2095Imported
OrganismiSulfolobus islandicus (strain HVE10/4)Imported
Taxonomic identifieri930943 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000006395: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1112Pyridoxal phosphate binding By similarityUniRule annotation
Regioni243 – 2464Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00823.
OMAiQHASTFG.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0NQG4-1 [UniParc]FASTAAdd to Basket

« Hide

MSKKVDELVK EDQEYLMQSF RRWYPFAIDR GSGAIVYDIE GKEYIDFNAG    50
IGVVALGHKN EKIISAVKEQ MEKFFHYSLT DFYYEIAVEV AKRLSSLMPF 100
SAKVFYTNSG TESVEAAIKI ARGHTRRQWI IGFLNSFHGR TLGSLAFTSS 150
KAIQRKSFSP LLPSTYLIPY PDKRDPLCKE DCTEALLGFI EDWIFKKVVD 200
PNEIAAFIAE PIQGEGGVIV PPKDFFYKLN NLLKKFGILL ILDEVQTGIG 250
RTGKMFAFEH FNVTPDLVCL AKALGGGLPL GAVIGRKEIM DLPPGSHANT 300
FGGNPLALAA AKVILEEVPK LLDHVSSIGK KIIEELKDTR SPYLYDVRGL 350
GLLIGAELRK DNKPFVEGLE KVLYNSFRRG VLAIGAGESV VRIEPPLIIE 400
EDLALKGTRI LIEEIEKL 418
Length:418
Mass (Da):46,575
Last modified:May 3, 2011 - v1
Checksum:i818CE94F75A644F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002426 Genomic DNA. Translation: ADX83439.1.
RefSeqiWP_014512956.1. NC_017275.1.
YP_005646653.1. NC_017275.1.

Genome annotation databases

EnsemblBacteriaiADX83439; ADX83439; SiH_2095.
GeneIDi12416214.
KEGGisih:SiH_2095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002426 Genomic DNA. Translation: ADX83439.1 .
RefSeqi WP_014512956.1. NC_017275.1.
YP_005646653.1. NC_017275.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADX83439 ; ADX83439 ; SiH_2095 .
GeneIDi 12416214.
KEGGi sih:SiH_2095.

Phylogenomic databases

KOi K00823.
OMAi QHASTFG.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00038 .
UPA00068 ; UER00109 .
BioCyci SISL930943:GLLW-2194-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome analyses of icelandic strains of Sulfolobus islandicus, model organisms for genetic and virus-host interaction studies."
    Guo L., Brugger K., Liu C., Shah S.A., Zheng H., Zhu Y., Wang S., Lillestol R.K., Chen L., Frank J., Prangishvili D., Paulin L., She Q., Huang L., Garrett R.A.
    J. Bacteriol. 193:1672-1680(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HVE10/4Imported.

Entry informationi

Entry nameiF0NQG4_SULIH
AccessioniPrimary (citable) accession number: F0NQG4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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