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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Sulfolobus islandicus (strain HVE10/4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciSISL930943:GLLW-72-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:SiH_0069Imported
OrganismiSulfolobus islandicus (strain HVE10/4)Imported
Taxonomic identifieri930943 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000006395 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiQSSFKYD.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

F0NMR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIIPRTMST QHPDNAKVPE WAKSEVIEGE DEVKEAFLAY SMYGVHEVMW
60 70 80 90 100
DAEGKDVDTH VVRKLLSNYP DYFREHILGK DVFLTYRLPN PKVEGADRKV
110 120 130 140 150
FAETMESIPI TYDLAEKFYG NGITVPVFEV ILPMTTSNLE IISVARYYEK
160 170 180 190 200
AVANEDELEL YDGVKVKDLV GEIYPKVIEV IPLVEDRDSL QNIDNIVEGY
210 220 230 240 250
YKVIKPKYMR VFLARSDPAM NYGMITAVLS VKIALSELYK LSESLNFEIY
260 270 280 290 300
PIIGVGSLPF RGHLSPENYE KVLEEYKGVY TYTIQSAFKY DYDYDKVKSA
310 320 330 340 350
ISSINNSRIG PAKILEKYEE DVLRKITILY TERYQPIIES LANAINDVSM
360 370 380 390 400
LLPRRRARKL HIGLFGYSRS AGKVSLPRAI SFVGSLYSIG IPPELIGISS
410 420 430 440 450
LSNLDEKEWD IFKQNYVNFK HDLQTAARFF NWESFELIKD IWKISEDTIA
460 470 480 490 500
KIKEDIDYAE SVIGIKLGDI DYDSRKHILM SSLFLLSFKE KILQESKKYL
510
YEMALIRRSL G
Length:511
Mass (Da):58,839
Last modified:May 2, 2011 - v1
Checksum:iF2174B790D5B4C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002426 Genomic DNA. Translation: ADX81441.1.
RefSeqiYP_005644655.1. NC_017275.1.

Genome annotation databases

EnsemblBacteriaiADX81441; ADX81441; SiH_0069.
GeneIDi12414089.
KEGGisih:SiH_0069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002426 Genomic DNA. Translation: ADX81441.1.
RefSeqiYP_005644655.1. NC_017275.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADX81441; ADX81441; SiH_0069.
GeneIDi12414089.
KEGGisih:SiH_0069.

Phylogenomic databases

KOiK01595.
OMAiQSSFKYD.

Enzyme and pathway databases

BioCyciSISL930943:GLLW-72-MONOMER.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome analyses of icelandic strains of Sulfolobus islandicus, model organisms for genetic and virus-host interaction studies."
    Guo L., Brugger K., Liu C., Shah S.A., Zheng H., Zhu Y., Wang S., Lillestol R.K., Chen L., Frank J., Prangishvili D., Paulin L., She Q., Huang L., Garrett R.A.
    J. Bacteriol. 193:1672-1680(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HVE10/4Imported.

Entry informationi

Entry nameiF0NMR2_SULIH
AccessioniPrimary (citable) accession number: F0NMR2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 2, 2011
Last sequence update: May 2, 2011
Last modified: March 31, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.