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F0N0E1

- F0N0E1_NEIMO

UniProt

F0N0E1 - F0N0E1_NEIMO

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Protein
Submitted name: Ferric enterobactin receptor
Gene
fetA, NMBM04240196_1925
Organism
Neisseria meningitidis serogroup B (strain M04-240196)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101IronImported
Metal bindingi111 – 1111Iron; via tele nitrogenImported
Metal bindingi325 – 3251IronImported
Metal bindingi551 – 5511Iron; via tele nitrogenImported

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. receptor activity Source: InterPro
  3. siderophore transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Ligandi

    IronImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciNMEN935593:GLHT-1924-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ferric enterobactin receptorImported
    Gene namesi
    Name:fetAImported
    Ordered Locus Names:NMBM04240196_1925Imported
    OrganismiNeisseria meningitidis serogroup B (strain M04-240196)Imported
    Taxonomic identifieri935593 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000007481: Chromosome

    Subcellular locationi

    Cell outer membrane By similarity UniRule annotation

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell outer membraneSAAS annotations, Membrane

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AIQX-ray2.60A23-723[»]

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TonB-dependent receptor family.UniRule annotation

    Keywords - Domaini

    TonB boxUniRule annotationSAAS annotations

    Phylogenomic databases

    KOiK16087.

    Family and domain databases

    Gene3Di2.170.130.10. 1 hit.
    2.40.170.20. 1 hit.
    InterProiIPR017690. OM_insertion_C_omp85_target.
    IPR012910. Plug.
    IPR000531. TonB-dep_rcpt_b-brl.
    IPR010917. TonB_rcpt_CS.
    IPR010105. TonB_sidphr_rcpt.
    [Graphical view]
    PfamiPF07715. Plug. 1 hit.
    PF00593. TonB_dep_Rec. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03304. OMP85_target. 2 hits.
    TIGR01783. TonB-siderophor. 1 hit.
    PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0N0E1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTPLFRLSL LSLTLAAGFA HAAENNAKVV LDTVTVKGDR QGSKIRTNIV    50
    TLQQKDESTA TDMRELLKEE PSIDFGGGNG TSQFLTLRGM GQNSVDIKVD 100
    NAYSDSQILY HQGRFIVDPA LVKVVSVQKG AGSASAGIGA TNGAIIAKTV 150
    DAQDLLKGLD KNWGVRLNSG FASNEGVSYG ASVFGKEGNF DGLFSYNRND 200
    EKEYEAGKGF RNFNGGKTVP YSALDKRSYL AKIGTTFGDG DHRIVLSHMK 250
    DQHRGIRTVR EEFTVGDASS RTNITRQAPS YRETTQSNTN LAYTGKDLGF 300
    VEKLDANAYV LEKKRYSADD KDNGYAGNVV GPNHTRITTR GMNFNFDSRL 350
    AEQTLLKYGI NYRHQEIKPQ AFLNGEFEIS GKKKDPKDPK KEIDKTDEEK 400
    AKDKKDMDLV HSYKLSNPTK TDTGAYIEAI HEIDGFTLTG GLRYDRFKVK 450
    THDGKTVSSS NLNPSFGVIW QPHEHWSFSS SHNYASRSPR LYDALQTHGK 500
    RGIISIADGT KAERARNTEI GFNYNDGTFA ANGSYFWQTI KDALANPQNR 550
    HVSAAVREAV NAGYIKNHGY ELGASYRTGG LTAKVGVSHS KPRFYDTHPK 600
    KLLSANPEFG AQVGRTWTAS LAYRFQNPNL EIGWRGRYVQ KAVGSILVAG 650
    QKDRNGKLEN VVRKGFGVND VFANWKPLGK DTLNVNLSVN NVFNTFYYPH 700
    SQRWTNTLPG VGRDVRLGVN YKF 723
    Length:723
    Mass (Da):80,013
    Last modified:May 3, 2011 - v1
    Checksum:i1B16D1B8AE0E6339
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002423 Genomic DNA. Translation: ADZ02346.1.
    RefSeqiYP_005898585.1. NC_017515.1.

    Genome annotation databases

    EnsemblBacteriaiADZ02346; ADZ02346; NMBM04240196_1925.
    GeneIDi12488988.
    KEGGinmq:NMBM04240196_1925.
    PATRICi47171466. VBINeiMen179694_2574.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002423 Genomic DNA. Translation: ADZ02346.1 .
    RefSeqi YP_005898585.1. NC_017515.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AIQ X-ray 2.60 A 23-723 [» ]
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADZ02346 ; ADZ02346 ; NMBM04240196_1925 .
    GeneIDi 12488988.
    KEGGi nmq:NMBM04240196_1925.
    PATRICi 47171466. VBINeiMen179694_2574.

    Phylogenomic databases

    KOi K16087.

    Enzyme and pathway databases

    BioCyci NMEN935593:GLHT-1924-MONOMER.

    Family and domain databases

    Gene3Di 2.170.130.10. 1 hit.
    2.40.170.20. 1 hit.
    InterProi IPR017690. OM_insertion_C_omp85_target.
    IPR012910. Plug.
    IPR000531. TonB-dep_rcpt_b-brl.
    IPR010917. TonB_rcpt_CS.
    IPR010105. TonB_sidphr_rcpt.
    [Graphical view ]
    Pfami PF07715. Plug. 1 hit.
    PF00593. TonB_dep_Rec. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03304. OMP85_target. 2 hits.
    TIGR01783. TonB-siderophor. 1 hit.
    PROSITEi PS01156. TONB_DEPENDENT_REC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination."
      Budroni S., Siena E., Dunning Hotopp J.C., Seib K.L., Serruto D., Nofroni C., Comanducci M., Riley D.R., Daugherty S.C., Angiuoli S.V., Covacci A., Pizza M., Rappuoli R., Moxon E.R., Tettelin H., Medini D.
      Proc. Natl. Acad. Sci. U.S.A. 108:4494-4499(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M04-240196Imported.
    2. "Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis."
      Saleem M., Prince S.M., Rigby S.E., Imran M., Patel H., Chan H., Sanders H., Maiden M.C., Feavers I.M., Derrick J.P.
      PLoS ONE 8:e56746-e56746(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 23-723 IN COMPLEX WITH IRON.

    Entry informationi

    Entry nameiF0N0E1_NEIMO
    AccessioniPrimary (citable) accession number: F0N0E1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: June 11, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome

    External Data

    Dasty 3

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