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Protein
Submitted name:

Ferric enterobactin receptor

Gene

fetA

Organism
Neisseria meningitidis serogroup B (strain M04-240196)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101IronCombined sources
Metal bindingi111 – 1111Iron; via tele nitrogenCombined sources
Metal bindingi325 – 3251IronCombined sources
Metal bindingi551 – 5511Iron; via tele nitrogenCombined sources

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. receptor activity Source: InterPro

GO - Biological processi

  1. siderophore transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Ligandi

IronCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciNMEN935593:GLHT-1924-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Ferric enterobactin receptorImported
Gene namesi
Name:fetAImported
Ordered Locus Names:NMBM04240196_1925Imported
OrganismiNeisseria meningitidis serogroup B (strain M04-240196)Imported
Taxonomic identifieri935593 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000007481: Chromosome

Subcellular locationi

Cell outer membrane UniRule annotation

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membraneSAAS annotation, Membrane

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIQX-ray2.60A23-723[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.UniRule annotation

Keywords - Domaini

TonB boxUniRule annotationSAAS annotation

Phylogenomic databases

KOiK16087.
OMAiNIYANIY.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR017690. OM_insertion_C_omp85_target.
IPR012910. Plug.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03304. OMP85_target. 2 hits.
TIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0N0E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPLFRLSL LSLTLAAGFA HAAENNAKVV LDTVTVKGDR QGSKIRTNIV
60 70 80 90 100
TLQQKDESTA TDMRELLKEE PSIDFGGGNG TSQFLTLRGM GQNSVDIKVD
110 120 130 140 150
NAYSDSQILY HQGRFIVDPA LVKVVSVQKG AGSASAGIGA TNGAIIAKTV
160 170 180 190 200
DAQDLLKGLD KNWGVRLNSG FASNEGVSYG ASVFGKEGNF DGLFSYNRND
210 220 230 240 250
EKEYEAGKGF RNFNGGKTVP YSALDKRSYL AKIGTTFGDG DHRIVLSHMK
260 270 280 290 300
DQHRGIRTVR EEFTVGDASS RTNITRQAPS YRETTQSNTN LAYTGKDLGF
310 320 330 340 350
VEKLDANAYV LEKKRYSADD KDNGYAGNVV GPNHTRITTR GMNFNFDSRL
360 370 380 390 400
AEQTLLKYGI NYRHQEIKPQ AFLNGEFEIS GKKKDPKDPK KEIDKTDEEK
410 420 430 440 450
AKDKKDMDLV HSYKLSNPTK TDTGAYIEAI HEIDGFTLTG GLRYDRFKVK
460 470 480 490 500
THDGKTVSSS NLNPSFGVIW QPHEHWSFSS SHNYASRSPR LYDALQTHGK
510 520 530 540 550
RGIISIADGT KAERARNTEI GFNYNDGTFA ANGSYFWQTI KDALANPQNR
560 570 580 590 600
HVSAAVREAV NAGYIKNHGY ELGASYRTGG LTAKVGVSHS KPRFYDTHPK
610 620 630 640 650
KLLSANPEFG AQVGRTWTAS LAYRFQNPNL EIGWRGRYVQ KAVGSILVAG
660 670 680 690 700
QKDRNGKLEN VVRKGFGVND VFANWKPLGK DTLNVNLSVN NVFNTFYYPH
710 720
SQRWTNTLPG VGRDVRLGVN YKF
Length:723
Mass (Da):80,013
Last modified:May 3, 2011 - v1
Checksum:i1B16D1B8AE0E6339
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002423 Genomic DNA. Translation: ADZ02346.1.
RefSeqiYP_005898585.1. NC_017515.1.

Genome annotation databases

EnsemblBacteriaiADZ02346; ADZ02346; NMBM04240196_1925.
GeneIDi12488988.
KEGGinmq:NMBM04240196_1925.
PATRICi47171466. VBINeiMen179694_2574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002423 Genomic DNA. Translation: ADZ02346.1.
RefSeqiYP_005898585.1. NC_017515.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIQX-ray2.60A23-723[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADZ02346; ADZ02346; NMBM04240196_1925.
GeneIDi12488988.
KEGGinmq:NMBM04240196_1925.
PATRICi47171466. VBINeiMen179694_2574.

Phylogenomic databases

KOiK16087.
OMAiNIYANIY.

Enzyme and pathway databases

BioCyciNMEN935593:GLHT-1924-MONOMER.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR017690. OM_insertion_C_omp85_target.
IPR012910. Plug.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03304. OMP85_target. 2 hits.
TIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination."
    Budroni S., Siena E., Hotopp J.C., Seib K.L., Serruto D., Nofroni C., Comanducci M., Riley D.R., Daugherty S.C., Angiuoli S.V., Covacci A., Pizza M., Rappuoli R., Moxon E.R., Tettelin H., Medini D.
    Proc. Natl. Acad. Sci. U.S.A. 108:4494-4499(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M04-240196Imported.
  2. "Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis."
    Saleem M., Prince S.M., Rigby S.E., Imran M., Patel H., Chan H., Sanders H., Maiden M.C., Feavers I.M., Derrick J.P.
    PLoS ONE 8:e56746-e56746(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 23-723 IN COMPLEX WITH IRON.

Entry informationi

Entry nameiF0N0E1_NEIMO
AccessioniPrimary (citable) accession number: F0N0E1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.