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F0MPC3 (F0MPC3_NEIMM) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:NMBM01240149_1664 EMBL ADY98219.1
OrganismNeisseria meningitidis serogroup B (strain M01-240149) [Complete proteome] [HAMAP] EMBL ADY98219.1
Taxonomic identifier935591 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain103 – 299197ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding129 – 18456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2531Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2681Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F0MPC3 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 66EFFD137C2B0BB0

FASTA30432,554
        10         20         30         40         50         60 
MQNFGKVAVL MGGFSSEREI SLDSGTAILN ALKSKGIDAY AFDPKETPLS ELKAQGFQTA 

        70         80         90        100        110        120 
FNILHGTYGE DGAVQGALEL LGIPYTGSGV AASAIGMDKY RCKLIWQALG LPVPEFAVLH 

       130        140        150        160        170        180 
DDTDFDAVEE KLGLPMFVKP AAEGSSVGVV KVKGKGRLKS VYEELKHLQG EIIAERFIGG 

       190        200        210        220        230        240 
GEYSCPVLNG KGLPGIHIIP ATEFYDYEAK YNRDDTIYQC PSEDLTEAEE SLMRELAVRG 

       250        260        270        280        290        300 
AQAIGAEGCV RVDFLKDTDG KLYLLEINTL PGMTSHSLVP KSAAVTGVGF ADLCIEILKT 


AHVG 

« Hide

References

[1]"Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination."
Budroni S., Siena E., Dunning Hotopp J.C., Seib K.L., Serruto D., Nofroni C., Comanducci M., Riley D.R., Daugherty S.C., Angiuoli S.V., Covacci A., Pizza M., Rappuoli R., Moxon E.R., Tettelin H., Medini D.
Proc. Natl. Acad. Sci. U.S.A. 108:4494-4499(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M01-240149 EMBL ADY98219.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002421 Genomic DNA. Translation: ADY98219.1.
RefSeqYP_005896430.1. NC_017514.1.

3D structure databases

ProteinModelPortalF0MPC3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADY98219; ADY98219; NMBM01240149_1664.
GeneID12413344.
KEGGnmm:NMBM01240149_1664.
PATRIC47158995. VBINeiMen175098_2256.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAKLAFQYD.

Enzyme and pathway databases

BioCycNMEN935591:GLHR-1663-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0MPC3_NEIMM
AccessionPrimary (citable) accession number: F0MPC3
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)