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F0MLA5

- F0MLA5_NEIMH

UniProt

F0MLA5 - F0MLA5_NEIMH

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, NMBH4476_2006
Organism
Neisseria meningitidis serogroup B / serotype 15 (strain H44/76)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401 By similarityUniRule annotation
Active sitei568 – 5681 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Enzyme and pathway databases

BioCyciNMEN909420:GLHQ-2005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:NMBH4476_2006Imported
OrganismiNeisseria meningitidis serogroup B / serotype 15 (strain H44/76)Imported
Taxonomic identifieri909420 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000008124: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF0MLA5.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiGIQITIN.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0MLA5-1 [UniParc]FASTAAdd to Basket

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MQLHILNNPK DAALAADAEF LKQSLFNLLH EEASPLVVET VKLLSTSDDS    50
AALIEKVLPQ LDEQQTHDLT LACGLFAQIL NIAEDVHHER RRQIHEEAGR 100
GGAEGSLTET VRRLKAGKAD GKSVQRQLDN TSVTAVLTAH PTEVQRQTVL 150
SFNRRIRALL PQRERCTNAD ALARLRREID TILLGLWQTS ETRRHKLSVN 200
DEINNGVSIF PMSFFEALPK LYRKMEHDFQ TAYPGVRVPD ILKIGGWIGG 250
DRDGNPFVSA ETLRFAFRRH ADAVFRFYRG ELDKLYRELP LSIRRVKVNG 300
DVTALSDKSP DEEIARAEEP YRRAIAYIMA RAMGKARALG LGMGCKFGFL 350
EPYASAQEFL DDLKKLQRSL IDNGSRLLAE GRLADLIRSV SVFGFHMMPL 400
DLRQHAGKHA DVVAELFQHA GLEDYNRLNE EQKQTALLRE LSHQRPLYSP 450
FITYSDHTRH ELAIFNEARK IKDEFGEDAV TQSIISNCEQ PSDLLALALL 500
LKETGLLAVE NGKPHSRINI VPLFETIEAL ENACPVMETM FRLDWYDALL 550
ESRGNIQEIM LGYSDSNKDG GYVTSSWCLY QAELGLVELF KKYDVRMRLF 600
HGRGGSVGRG GGPSYQAILA QPAGSVAGQI RITEQGEVIT AKYADPGNAQ 650
RNLETLVAAT LEASILPDKK DPDAKLMQAL SDVSFKYYRE LITHPDFIDY 700
FLQTSPIQEI ATLNLGSRPA SRKTLARIQD LRAIPWVFSW MQNRLMLPAW 750
YGFGSAVETL CEDKPETLAA LREHAQSNPF FQAMLSNMEQ VMAKTDITLA 800
ENYAGLSESP DKAKIIFGMI KEEYRRSRKA LLDLLQTEEL LRDNRSLARS 850
LALRIPYLNA LNGLQVAMLK RLRKEPDNPH ALLMVHLTIN GVAQGLRNTG 900
Length:900
Mass (Da):101,210
Last modified:May 3, 2011 - v1
Checksum:i489B26F74AA06012
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002420 Genomic DNA. Translation: ADY96564.1.
RefSeqiYP_005900619.1. NC_017516.1.

Genome annotation databases

EnsemblBacteriaiADY96564; ADY96564; NMBH4476_2006.
GeneIDi12491170.
KEGGinmh:NMBH4476_2006.
PATRICi47154016. VBINeiMen174185_2698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002420 Genomic DNA. Translation: ADY96564.1 .
RefSeqi YP_005900619.1. NC_017516.1.

3D structure databases

ProteinModelPortali F0MLA5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADY96564 ; ADY96564 ; NMBH4476_2006 .
GeneIDi 12491170.
KEGGi nmh:NMBH4476_2006.
PATRICi 47154016. VBINeiMen174185_2698.

Phylogenomic databases

KOi K01595.
OMAi GIQITIN.

Enzyme and pathway databases

BioCyci NMEN909420:GLHQ-2005-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination."
    Budroni S., Siena E., Dunning Hotopp J.C., Seib K.L., Serruto D., Nofroni C., Comanducci M., Riley D.R., Daugherty S.C., Angiuoli S.V., Covacci A., Pizza M., Rappuoli R., Moxon E.R., Tettelin H., Medini D.
    Proc. Natl. Acad. Sci. U.S.A. 108:4494-4499(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H44/76Imported.

Entry informationi

Entry nameiF0MLA5_NEIMH
AccessioniPrimary (citable) accession number: F0MLA5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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