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Protein

Probable DNA ligase

Gene

lig

Organism
Arthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATPUniRule annotation
Active sitei211 – 2111N6-AMP-lysine intermediateUniRule annotation
Binding sitei216 – 2161ATPUniRule annotation
Binding sitei231 – 2311ATPUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei295 – 2951ATPUniRule annotation
Binding sitei366 – 3661ATPUniRule annotation
Binding sitei372 – 3721ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPHE930171:GJHZ-2718-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Asphe3_27260Imported
OrganismiArthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)Imported
Taxonomic identifieri930171 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000008639: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF0M945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0M945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDELVNTT QAVASTRSRL AKVDALAGLL KRLEPAEIAT AVGLLIARPR
60 70 80 90 100
QGRVGVGWSG MKAAMGEPAA EPSLTVAEVD AALDRLLGTA GTGSAAERAG
110 120 130 140 150
ILRTLTGAAT EREQAFIAGV LLGELRTGAL EGVLTDAVAR AAGRPADAVR
160 170 180 190 200
RAAMLSGDLG GTALLALTGT AEQLDAVGLV VGRPVQPMLA ATASSVSDAL
210 220 230 240 250
GTTGEASVEY KLDGARIQVH RAGDDVRVYT RTLAEVTHRL PEVVEVVRGL
260 270 280 290 300
PVREVILDGE TLALDEDGGP RPFQETMSRF GADAARDTLL HPWFFDVLHI
310 320 330 340 350
DGRDLLDEPL ATRIGVLESI APGHRIPGEV TADVAVAEKV SREALAAGHE
360 370 380 390 400
GVVVKAIGSA YAAGRRGSNW VKVKPVLTYD LVVLACEWGS GRRTGLLSNL
410 420 430 440 450
HLGALDPLGE FGAPGGYVMV GKTFKGLTDA LLKWQTARFQ ELEVRRTAGT
460 470 480 490 500
VWVEPVTVVE IAIDGVQQSP RYPGGIALRF ARVKRYRDDK TAAEADTIQT

LRALLRP
Length:507
Mass (Da):53,440
Last modified:May 3, 2011 - v1
Checksum:iD2A727A1DBF63FF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002379 Genomic DNA. Translation: ADX73845.1.
RefSeqiWP_013601755.1. NC_015145.1.
YP_004241979.1. NC_015145.1.

Genome annotation databases

EnsemblBacteriaiADX73845; ADX73845; Asphe3_27260.
GeneIDi10286093.
KEGGiapn:Asphe3_27260.
PATRICi46863824. VBIArtPhe178037_2701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002379 Genomic DNA. Translation: ADX73845.1.
RefSeqiWP_013601755.1. NC_015145.1.
YP_004241979.1. NC_015145.1.

3D structure databases

ProteinModelPortaliF0M945.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADX73845; ADX73845; Asphe3_27260.
GeneIDi10286093.
KEGGiapn:Asphe3_27260.
PATRICi46863824. VBIArtPhe178037_2701.

Phylogenomic databases

KOiK10747.

Enzyme and pathway databases

BioCyciAPHE930171:GJHZ-2718-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18606 / JCM 16027 / LMG 23796 / Sphe3Imported.

Entry informationi

Entry nameiF0M945_ARTPP
AccessioniPrimary (citable) accession number: F0M945
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.