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Protein

Probable DNA ligase

Gene

lig

Organism
Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (Arthrobacter phenanthrenivorans)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei209ATPUniRule annotation1
Active sitei211N6-AMP-lysine intermediateUniRule annotation1
Binding sitei216ATPUniRule annotation1
Binding sitei231ATPUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei366ATPUniRule annotation1
Binding sitei372ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Asphe3_27260Imported
OrganismiPseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) (Arthrobacter phenanthrenivorans)Imported
Taxonomic identifieri930171 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000008639 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi930171.Asphe3_27260.

Structurei

3D structure databases

ProteinModelPortaliF0M945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini293 – 406DNA_LIGASE_A3InterPro annotationAdd BLAST114

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT. Bacteria.
COG1793. LUCA.
KOiK10747.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0M945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDELVNTT QAVASTRSRL AKVDALAGLL KRLEPAEIAT AVGLLIARPR
60 70 80 90 100
QGRVGVGWSG MKAAMGEPAA EPSLTVAEVD AALDRLLGTA GTGSAAERAG
110 120 130 140 150
ILRTLTGAAT EREQAFIAGV LLGELRTGAL EGVLTDAVAR AAGRPADAVR
160 170 180 190 200
RAAMLSGDLG GTALLALTGT AEQLDAVGLV VGRPVQPMLA ATASSVSDAL
210 220 230 240 250
GTTGEASVEY KLDGARIQVH RAGDDVRVYT RTLAEVTHRL PEVVEVVRGL
260 270 280 290 300
PVREVILDGE TLALDEDGGP RPFQETMSRF GADAARDTLL HPWFFDVLHI
310 320 330 340 350
DGRDLLDEPL ATRIGVLESI APGHRIPGEV TADVAVAEKV SREALAAGHE
360 370 380 390 400
GVVVKAIGSA YAAGRRGSNW VKVKPVLTYD LVVLACEWGS GRRTGLLSNL
410 420 430 440 450
HLGALDPLGE FGAPGGYVMV GKTFKGLTDA LLKWQTARFQ ELEVRRTAGT
460 470 480 490 500
VWVEPVTVVE IAIDGVQQSP RYPGGIALRF ARVKRYRDDK TAAEADTIQT

LRALLRP
Length:507
Mass (Da):53,440
Last modified:May 3, 2011 - v1
Checksum:iD2A727A1DBF63FF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002379 Genomic DNA. Translation: ADX73845.1.
RefSeqiWP_013601755.1. NC_015145.1.

Genome annotation databases

EnsemblBacteriaiADX73845; ADX73845; Asphe3_27260.
KEGGiapn:Asphe3_27260.
PATRICi46863824. VBIArtPhe178037_2701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002379 Genomic DNA. Translation: ADX73845.1.
RefSeqiWP_013601755.1. NC_015145.1.

3D structure databases

ProteinModelPortaliF0M945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi930171.Asphe3_27260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADX73845; ADX73845; Asphe3_27260.
KEGGiapn:Asphe3_27260.
PATRICi46863824. VBIArtPhe178037_2701.

Phylogenomic databases

eggNOGiENOG4107RYT. Bacteria.
COG1793. LUCA.
KOiK10747.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF0M945_PSEPM
AccessioniPrimary (citable) accession number: F0M945
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 2, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.