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F0M945

- F0M945_ARTPP

UniProt

F0M945 - F0M945_ARTPP

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Protein
Probable DNA ligase
Gene
lig, Asphe3_27260
Organism
Arthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATP By similarityUniRule annotation
Active sitei211 – 2111N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei216 – 2161ATP By similarityUniRule annotation
Binding sitei231 – 2311ATP By similarityUniRule annotation
Binding sitei260 – 2601ATP By similarityUniRule annotation
Binding sitei295 – 2951ATP By similarityUniRule annotation
Binding sitei366 – 3661ATP By similarityUniRule annotation
Binding sitei372 – 3721ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPHE930171:GJHZ-2718-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Asphe3_27260Imported
OrganismiArthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)Imported
Taxonomic identifieri930171 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000008639: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF0M945.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0M945-1 [UniParc]FASTAAdd to Basket

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MLLDELVNTT QAVASTRSRL AKVDALAGLL KRLEPAEIAT AVGLLIARPR    50
QGRVGVGWSG MKAAMGEPAA EPSLTVAEVD AALDRLLGTA GTGSAAERAG 100
ILRTLTGAAT EREQAFIAGV LLGELRTGAL EGVLTDAVAR AAGRPADAVR 150
RAAMLSGDLG GTALLALTGT AEQLDAVGLV VGRPVQPMLA ATASSVSDAL 200
GTTGEASVEY KLDGARIQVH RAGDDVRVYT RTLAEVTHRL PEVVEVVRGL 250
PVREVILDGE TLALDEDGGP RPFQETMSRF GADAARDTLL HPWFFDVLHI 300
DGRDLLDEPL ATRIGVLESI APGHRIPGEV TADVAVAEKV SREALAAGHE 350
GVVVKAIGSA YAAGRRGSNW VKVKPVLTYD LVVLACEWGS GRRTGLLSNL 400
HLGALDPLGE FGAPGGYVMV GKTFKGLTDA LLKWQTARFQ ELEVRRTAGT 450
VWVEPVTVVE IAIDGVQQSP RYPGGIALRF ARVKRYRDDK TAAEADTIQT 500
LRALLRP 507
Length:507
Mass (Da):53,440
Last modified:May 3, 2011 - v1
Checksum:iD2A727A1DBF63FF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002379 Genomic DNA. Translation: ADX73845.1.
RefSeqiYP_004241979.1. NC_015145.1.

Genome annotation databases

EnsemblBacteriaiADX73845; ADX73845; Asphe3_27260.
GeneIDi10286093.
KEGGiapn:Asphe3_27260.
PATRICi46863824. VBIArtPhe178037_2701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002379 Genomic DNA. Translation: ADX73845.1 .
RefSeqi YP_004241979.1. NC_015145.1.

3D structure databases

ProteinModelPortali F0M945.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADX73845 ; ADX73845 ; Asphe3_27260 .
GeneIDi 10286093.
KEGGi apn:Asphe3_27260.
PATRICi 46863824. VBIArtPhe178037_2701.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci APHE930171:GJHZ-2718-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18606 / JCM 16027 / LMG 23796 / Sphe3.

Entry informationi

Entry nameiF0M945_ARTPP
AccessioniPrimary (citable) accession number: F0M945
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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