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F0M7D8

- F0M7D8_ARTPP

UniProt

F0M7D8 - F0M7D8_ARTPP

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Protein

Kynureninase

Gene
Asphe3_14180
Organism
Arthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  2. NAD biosynthetic process Source: UniProtKB-UniPathway
  3. tryptophan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciAPHE930171:GJHZ-1415-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:Asphe3_14180Imported
OrganismiArthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)Imported
Taxonomic identifieri930171 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000008639: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

F0M7D8-1 [UniParc]FASTAAdd to Basket

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MSMDQQSPTK DAQTWLQQRA VELDNKDPLA HCRQHFIGTD TPLSYLDGNS    50
LGRPLKRTPD DISRFITQGW GGRLIRGWDE EWLDLPQSIG DQLGRAVLGA 100
APGQTIIADS TTVVLYKLIR AALAAVADPD RNELVLDTEN FPTDRYLVEG 150
IALEEGLTLR WIQADPAAGV TVQQVREATG PRTAVVLLSQ VAYRSGHLAD 200
LPAITAAVHD AGALVVWDLC HSAGSVEIGL DSAGVDFAAG CTYKYLNGGP 250
GSPAFAYVNQ RHLASLNQPI WGWMGRKDAF EMAAGYEPAA GIRGFLSGTP 300
AVFGMLAMRG TLDLIEEATM AAIREKSIQL TDFAVEVFDA LLAPLGAELG 350
TPREPARRGS HITVDHPDFT KATVEALWAG DVIPDFRSPH GIRVGLSPLS 400
TSFQETLQGM AAMRDRLQG 419
Length:419
Mass (Da):45,191
Last modified:May 3, 2011 - v1
Checksum:i5101A40A86752D77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002379 Genomic DNA. Translation: ADX72592.1.
RefSeqiWP_013600531.1. NC_015145.1.
YP_004240726.1. NC_015145.1.

Genome annotation databases

EnsemblBacteriaiADX72592; ADX72592; Asphe3_14180.
GeneIDi10284790.
KEGGiapn:Asphe3_14180.
PATRICi46861172. VBIArtPhe178037_1411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002379 Genomic DNA. Translation: ADX72592.1 .
RefSeqi WP_013600531.1. NC_015145.1.
YP_004240726.1. NC_015145.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADX72592 ; ADX72592 ; Asphe3_14180 .
GeneIDi 10284790.
KEGGi apn:Asphe3_14180.
PATRICi 46861172. VBIArtPhe178037_1411.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci APHE930171:GJHZ-1415-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18606 / JCM 16027 / LMG 23796 / Sphe3.

Entry informationi

Entry nameiF0M7D8_ARTPP
AccessioniPrimary (citable) accession number: F0M7D8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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