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F0M7D8

- F0M7D8_ARTPP

UniProt

F0M7D8 - F0M7D8_ARTPP

Protein

Kynureninase

Gene

Asphe3_14180

Organism
Arthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    2. NAD biosynthetic process Source: UniProtKB-UniPathway
    3. tryptophan catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciAPHE930171:GJHZ-1415-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Gene namesi
    Ordered Locus Names:Asphe3_14180Imported
    OrganismiArthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3)Imported
    Taxonomic identifieri930171 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000008639: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F0M7D8-1 [UniParc]FASTAAdd to Basket

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    MSMDQQSPTK DAQTWLQQRA VELDNKDPLA HCRQHFIGTD TPLSYLDGNS    50
    LGRPLKRTPD DISRFITQGW GGRLIRGWDE EWLDLPQSIG DQLGRAVLGA 100
    APGQTIIADS TTVVLYKLIR AALAAVADPD RNELVLDTEN FPTDRYLVEG 150
    IALEEGLTLR WIQADPAAGV TVQQVREATG PRTAVVLLSQ VAYRSGHLAD 200
    LPAITAAVHD AGALVVWDLC HSAGSVEIGL DSAGVDFAAG CTYKYLNGGP 250
    GSPAFAYVNQ RHLASLNQPI WGWMGRKDAF EMAAGYEPAA GIRGFLSGTP 300
    AVFGMLAMRG TLDLIEEATM AAIREKSIQL TDFAVEVFDA LLAPLGAELG 350
    TPREPARRGS HITVDHPDFT KATVEALWAG DVIPDFRSPH GIRVGLSPLS 400
    TSFQETLQGM AAMRDRLQG 419
    Length:419
    Mass (Da):45,191
    Last modified:May 3, 2011 - v1
    Checksum:i5101A40A86752D77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002379 Genomic DNA. Translation: ADX72592.1.
    RefSeqiWP_013600531.1. NC_015145.1.
    YP_004240726.1. NC_015145.1.

    Genome annotation databases

    EnsemblBacteriaiADX72592; ADX72592; Asphe3_14180.
    GeneIDi10284790.
    KEGGiapn:Asphe3_14180.
    PATRICi46861172. VBIArtPhe178037_1411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002379 Genomic DNA. Translation: ADX72592.1 .
    RefSeqi WP_013600531.1. NC_015145.1.
    YP_004240726.1. NC_015145.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADX72592 ; ADX72592 ; Asphe3_14180 .
    GeneIDi 10284790.
    KEGGi apn:Asphe3_14180.
    PATRICi 46861172. VBIArtPhe178037_1411.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci APHE930171:GJHZ-1415-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 18606 / JCM 16027 / LMG 23796 / Sphe3Imported.

    Entry informationi

    Entry nameiF0M7D8_ARTPP
    AccessioniPrimary (citable) accession number: F0M7D8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3