F0M7D8 (F0M7D8_ARTPP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

Asphe3_14180 EMBL ADX72592.1

Organism

Arthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) [Complete proteome] [HAMAP] EMBL ADX72592.1

Taxonomic identifier

930171 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter › Arthrobacter phenanthrenivorans

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800 EMBL ADX72592.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-kynurenine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F0M7D8 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 5101A40A86752D77	FASTA	419	45,191
	10 20 30 40 50 60 MSMDQQSPTK DAQTWLQQRA VELDNKDPLA HCRQHFIGTD TPLSYLDGNS LGRPLKRTPD 70 80 90 100 110 120 DISRFITQGW GGRLIRGWDE EWLDLPQSIG DQLGRAVLGA APGQTIIADS TTVVLYKLIR 130 140 150 160 170 180 AALAAVADPD RNELVLDTEN FPTDRYLVEG IALEEGLTLR WIQADPAAGV TVQQVREATG 190 200 210 220 230 240 PRTAVVLLSQ VAYRSGHLAD LPAITAAVHD AGALVVWDLC HSAGSVEIGL DSAGVDFAAG 250 260 270 280 290 300 CTYKYLNGGP GSPAFAYVNQ RHLASLNQPI WGWMGRKDAF EMAAGYEPAA GIRGFLSGTP 310 320 330 340 350 360 AVFGMLAMRG TLDLIEEATM AAIREKSIQL TDFAVEVFDA LLAPLGAELG TPREPARRGS 370 380 390 400 410 HITVDHPDFT KATVEALWAG DVIPDFRSPH GIRVGLSPLS TSFQETLQGM AAMRDRLQG

References

[1]

"Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3)." Kallimanis A., Labutti K.M., Lapidus A., Clum A., Lykidis A., Mavromatis K., Pagani I., Liolios K., Ivanova N., Goodwin L., Pitluck S., Chen A., Palaniappan K., Markowitz V., Bristow J., Velentzas A.D., Perisynakis A., Ouzounis C.C. , Kyrpides N.C., Koukkou A.I., Drainas C. Stand. Genomic Sci. 4:123-130(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 18606 / JCM 16027 / LMG 23796 / Sphe3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002379 Genomic DNA. Translation: ADX72592.1.
RefSeq	YP_004240726.1. NC_015145.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADX72592; ADX72592; Asphe3_14180.
GeneID	10284790.
KEGG	apn:Asphe3_14180.
PATRIC	46861172. VBIArtPhe178037_1411.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01556.
Enzyme and pathway databases
BioCyc	APHE930171:GJHZ-1415-MONOMER.
UniPathway	UPA00253; UER00329. UPA00334; UER00455.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR14084. PTHR14084. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F0M7D8_ARTPP

Accession

Primary (citable) accession number: F0M7D8

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)