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F0M548 (F0M548_ARTPP) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Asphe3_23780 EMBL ADX73512.1
OrganismArthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG 23796 / Sphe3) [Complete proteome] [HAMAP] EMBL ADX73512.1
Taxonomic identifier930171 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential EMBL ADX73512.1
Chain32 – 382351 Potential EMBL ADX73512.1
PRO_5000714359

Regions

Domain161 – 372212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding193 – 24856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3261Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3391Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3391Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3411Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F0M548 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: AB15614B3519AE79

FASTA38240,611
        10         20         30         40         50         60 
MSHDKLAAGE SVNRAKPRVA VLFGGRSSEH AVSCVTAAGV LGAINKDKYE VIPIGIAKSG 

        70         80         90        100        110        120 
QWVLVSADTA QWSLAATSLP EVAPSAKSVT LAEIGGEHQL IVAAPNEVPQ ELGTVDVVFP 

       130        140        150        160        170        180 
LLHGPFGEDG TIQGLLELSD TRYVGAGVLA SAVGMDKHFM KVVFESAGLQ VGPYVAVTDR 

       190        200        210        220        230        240 
QWRKDPESVR KQVDRLGFPV FVKPARAGSS MGISKVESMA ELDAAIEEAR RHDLKLVIEA 

       250        260        270        280        290        300 
GITGREIECA VLEGRGTDAP RTSMPGEISV AGGTHEFYDF NAKYVEDGAA ALSCPADIPE 

       310        320        330        340        350        360 
EAIARVRELA AAAFDAVGAE GLSRVDFFYT PAGELIINEI NTMPGFTPKS MYPQMWAASG 

       370        380 
LDYADLIDEL IYLALNRKTG LR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002379 Genomic DNA. Translation: ADX73512.1.
RefSeqYP_004241646.1. NC_015145.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADX73512; ADX73512; Asphe3_23780.
GeneID10285746.
KEGGapn:Asphe3_23780.
PATRIC46863117. VBIArtPhe178037_2358.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycAPHE930171:GJHZ-2371-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0M548_ARTPP
AccessionPrimary (citable) accession number: F0M548
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)