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Protein

2-aminoethylphosphonate--pyruvate transaminase

Gene

phnW

Organism
Vibrio furnissii (strain DSM 14383 / NCTC 11218)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotationSAAS annotation

Catalytic activityi

(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. 2-aminoethylphosphonate-pyruvate transaminase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. organic phosphonate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation, PyruvateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVFUR903510:GHFS-3237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethylphosphonate--pyruvate transaminaseUniRule annotationSAAS annotation (EC:2.6.1.37UniRule annotationSAAS annotation)
Alternative name(s):
2-aminoethylphosphonate aminotransferaseUniRule annotation
AEP transaminaseUniRule annotation
Gene namesi
Name:phnWUniRule annotation
Ordered Locus Names:vfu_B00116Imported
OrganismiVibrio furnissii (strain DSM 14383 / NCTC 11218)Imported
Taxonomic identifieri903510 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000007456 Componenti: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei193 – 1931N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.UniRule annotation

Phylogenomic databases

KOiK03430.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.

Sequencei

Sequence statusi: Complete.

F0M0N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNDYLLLTP GPLSTTETVR EAMLKDWCTW DDEYNKDIVE VIRQKLVALA
60 70 80 90 100
TRHSGYTSVL MQGSGTASVE ATIGSTLGQH GKLLVVDNGA YGARIAQIAA
110 120 130 140 150
YLHIDCAIVS PGETAQPSLE HIETCLQQDA TITHVAIVHC ETTTGMLNPI
160 170 180 190 200
AEVVALAKRY GKTVIVDAMS SFGGIPMDIG DLGIDFMISS ANKCIQGVPG
210 220 230 240 250
FGFVIAKQSE LEQCQGQARS LSLDLYDQWQ CMEKNHGKWR FTSPTHTVRA
260 270 280 290 300
FYQALLELEQ EGGIAARHQR YQTNQTTLVR GMQSLGFTPL LDVSLHSPII
310 320 330 340 350
TSFYSPTHPD YQFAEFYQRL KAQGFVIYPG KVSHADCFRI GNIGDVHPHD
360
IERLIEAVQN AMYWNVAS
Length:368
Mass (Da):40,644
Last modified:May 2, 2011 - v1
Checksum:i447323255165EFBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002378 Genomic DNA. Translation: ADT88368.1.
RefSeqiYP_005048688.1. NC_016628.1.

Genome annotation databases

EnsemblBacteriaiADT88368; ADT88368; vfu_B00116.
KEGGivfu:vfu_B00116.
PATRICi45430787. VBIVibFur169925_3170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002378 Genomic DNA. Translation: ADT88368.1.
RefSeqiYP_005048688.1. NC_016628.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADT88368; ADT88368; vfu_B00116.
KEGGivfu:vfu_B00116.
PATRICi45430787. VBIVibFur169925_3170.

Phylogenomic databases

KOiK03430.

Enzyme and pathway databases

BioCyciVFUR903510:GHFS-3237-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of a free-living Vibrio furnissii sp. nov. strain (NCTC 11218)."
    Lux T.M., Lee R., Love J.
    J. Bacteriol. 193:1487-1488(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14383 / NCTC 11218Imported.

Entry informationi

Entry nameiF0M0N2_VIBFN
AccessioniPrimary (citable) accession number: F0M0N2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 2, 2011
Last sequence update: May 2, 2011
Last modified: March 31, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.