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F0LX19 (F0LX19_VIBFN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:vfu_B00227 EMBL ADT88474.1
OrganismVibrio furnissii (strain DSM 14383 / NCTC 11218) [Complete proteome] [HAMAP] EMBL ADT88474.1
Taxonomic identifier903510 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 327207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding151 – 20656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2811Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2941Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2941Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2961Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F0LX19 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 2B807DB4D97456E8

FASTA33437,147
        10         20         30         40         50         60 
MTKTTILLLC GGGSSEHEVS LVSANYLQQQ LSLTPDFDVV RVEMKKEGWF SDTGEIVYLD 

        70         80         90        100        110        120 
TNSATLNGEG LSLKIDFVIP CIHGYPGETG DIQSMFELAG IPYLGCGPEA SSNSFNKITS 

       130        140        150        160        170        180 
KLWYDALDIP NTPYLFLSEN NAQALKNTQD AFAKWGSLFI KAARQGSSVG CYKVTKEDQI 

       190        200        210        220        230        240 
AAAIDAAFSY SEQVLVEQAV KPRELEVAAY EMNGELFITK PGEIIAPEDA FYSYEEKYST 

       250        260        270        280        290        300 
DSHSRTEVEA GNLTDEQQAL IHQVAQKVFT HMKLRHLSRI DFFLTPEGHV YLNEVNTFPG 

       310        320        330 
MTPISMFPKM LENNGHQFDE FLADCVRRSL TPKA 

« Hide

References

[1]"Complete genome sequence of a free-living Vibrio furnissii sp. nov. strain (NCTC 11218)."
Lux T.M., Lee R., Love J.
J. Bacteriol. 193:1487-1488(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14383 / NCTC 11218.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002378 Genomic DNA. Translation: ADT88474.1.
RefSeqYP_005048794.1. NC_016628.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADT88474; ADT88474; vfu_B00227.
GeneID11564482.
KEGGvfu:vfu_B00227.
PATRIC45431004. VBIVibFur169925_3277.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycVFUR903510:GHFS-3344-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0LX19_VIBFN
AccessionPrimary (citable) accession number: F0LX19
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)