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Protein

DNA ligase

Gene

lig

Organism
Thermococcus barophilus (strain DSM 11836 / MP)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation
NAD+ + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATPUniRule annotation
Active sitei250 – 2501N6-AMP-lysine intermediateUniRule annotation
Binding sitei255 – 2551ATPUniRule annotation
Binding sitei270 – 2701ATPUniRule annotation
Binding sitei300 – 3001ATPUniRule annotation
Binding sitei340 – 3401ATPUniRule annotation
Binding sitei415 – 4151ATPUniRule annotation
Binding sitei421 – 4211ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTBAR391623:GH3I-1995-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation, EC:6.5.1.6UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP/NAD(+)]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TERMP_01956Imported
OrganismiThermococcus barophilus (strain DSM 11836 / MP)Imported
Taxonomic identifieri391623 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000007478 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi391623.TERMP_01956.

Structurei

3D structure databases

ProteinModelPortaliF0LL23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0LL23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYKELAELY RRLEKTTLKT LKTRFVADFL KKVEDEELLE IVPYLILGKV
60 70 80 90 100
FPDWDERELG VGEKLLIKAV AMATGINAEW IENSVKDTGD LGESVALALQ
110 120 130 140 150
KRKQRSFFGQ PLTIKRVYKT LVKVAETTGE GSQDRKLKYL ANLFMDAEPI
160 170 180 190 200
EGKYLARTIL GTMRTGVAEG LLRDAIAEAF RVKPELVERA YMLTSDFGFV
210 220 230 240 250
TKIAKLEGNE GLSKVTIQIG KPIKPMLAQM AANVREALVE MGGEAEFEIK
260 270 280 290 300
YDGARVQVHK DGDKVIIYSR RLENVTKSIP EVVERIKKSI KPEKAIVEGE
310 320 330 340 350
LVAVGEGGRP RPFQYVLRRF RRKYNIQEMI EKIPLELNLF DVLYVDGENL
360 370 380 390 400
IDTPFIERRK KLESIVEVNQ WIKVAENLIT KSPEEAEEFY HKALDMGHEG
410 420 430 440 450
LMAKRLDSVY EPGNRGKKWL KIKPTMENLD LVIIGAEWGE GRRAHVLSSF
460 470 480 490 500
LLGAYDPGTG TFVPVGKVGS GFTDEDLVEF TKMLKPLIKK EKGKFVEIEP
510 520 530 540 550
KVVIEVTYQE IQKSPKYESG FALRFPRYVA LREDKSPEDA DTLERIAQLY
560
ELQERMKAGK R
Length:561
Mass (Da):63,886
Last modified:May 3, 2011 - v1
Checksum:i1F16B32ED6C1A660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002372 Genomic DNA. Translation: ADT84930.1.
RefSeqiWP_013468226.1. NC_014804.1.
YP_004072153.1. NC_014804.1.

Genome annotation databases

EnsemblBacteriaiADT84930; ADT84930; TERMP_01956.
GeneIDi10042271.
KEGGitba:TERMP_01956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002372 Genomic DNA. Translation: ADT84930.1.
RefSeqiWP_013468226.1. NC_014804.1.
YP_004072153.1. NC_014804.1.

3D structure databases

ProteinModelPortaliF0LL23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391623.TERMP_01956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADT84930; ADT84930; TERMP_01956.
GeneIDi10042271.
KEGGitba:TERMP_01956.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciTBAR391623:GH3I-1995-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP."
    Vannier P., Marteinsson V.T., Fridjonsson O.H., Oger P., Jebbar M.
    J. Bacteriol. 193:1481-1482(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11836 / MPImported.

Entry informationi

Entry nameiF0LL23_THEBM
AccessioniPrimary (citable) accession number: F0LL23
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 24, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.