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F0LL23

- F0LL23_THEBM

UniProt

F0LL23 - F0LL23_THEBM

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Protein

DNA ligase

Gene
lig, TERMP_01956
Organism
Thermococcus barophilus (strain DSM 11836 / MP)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATP By similarityUniRule annotation
Active sitei250 – 2501N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei255 – 2551ATP By similarityUniRule annotation
Binding sitei270 – 2701ATP By similarityUniRule annotation
Binding sitei300 – 3001ATP By similarityUniRule annotation
Binding sitei340 – 3401ATP By similarityUniRule annotation
Binding sitei415 – 4151ATP By similarityUniRule annotation
Binding sitei421 – 4211ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTBAR391623:GH3I-1995-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TERMP_01956Imported
OrganismiThermococcus barophilus (strain DSM 11836 / MP)Imported
Taxonomic identifieri391623 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000007478: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF0LL23.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0LL23-1 [UniParc]FASTAAdd to Basket

« Hide

MLYKELAELY RRLEKTTLKT LKTRFVADFL KKVEDEELLE IVPYLILGKV    50
FPDWDERELG VGEKLLIKAV AMATGINAEW IENSVKDTGD LGESVALALQ 100
KRKQRSFFGQ PLTIKRVYKT LVKVAETTGE GSQDRKLKYL ANLFMDAEPI 150
EGKYLARTIL GTMRTGVAEG LLRDAIAEAF RVKPELVERA YMLTSDFGFV 200
TKIAKLEGNE GLSKVTIQIG KPIKPMLAQM AANVREALVE MGGEAEFEIK 250
YDGARVQVHK DGDKVIIYSR RLENVTKSIP EVVERIKKSI KPEKAIVEGE 300
LVAVGEGGRP RPFQYVLRRF RRKYNIQEMI EKIPLELNLF DVLYVDGENL 350
IDTPFIERRK KLESIVEVNQ WIKVAENLIT KSPEEAEEFY HKALDMGHEG 400
LMAKRLDSVY EPGNRGKKWL KIKPTMENLD LVIIGAEWGE GRRAHVLSSF 450
LLGAYDPGTG TFVPVGKVGS GFTDEDLVEF TKMLKPLIKK EKGKFVEIEP 500
KVVIEVTYQE IQKSPKYESG FALRFPRYVA LREDKSPEDA DTLERIAQLY 550
ELQERMKAGK R 561
Length:561
Mass (Da):63,886
Last modified:May 3, 2011 - v1
Checksum:i1F16B32ED6C1A660
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002372 Genomic DNA. Translation: ADT84930.1.
RefSeqiYP_004072153.1. NC_014804.1.

Genome annotation databases

EnsemblBacteriaiADT84930; ADT84930; TERMP_01956.
GeneIDi10042271.
KEGGitba:TERMP_01956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002372 Genomic DNA. Translation: ADT84930.1 .
RefSeqi YP_004072153.1. NC_014804.1.

3D structure databases

ProteinModelPortali F0LL23.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADT84930 ; ADT84930 ; TERMP_01956 .
GeneIDi 10042271.
KEGGi tba:TERMP_01956.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci TBAR391623:GH3I-1995-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP."
    Vannier P., Marteinsson V.T., Fridjonsson O.H., Oger P., Jebbar M.
    J. Bacteriol. 193:1481-1482(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11836 / MP.

Entry informationi

Entry nameiF0LL23_THEBM
AccessioniPrimary (citable) accession number: F0LL23
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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