Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F0LL23

- F0LL23_THEBM

UniProt

F0LL23 - F0LL23_THEBM

Protein

DNA ligase

Gene

lig

Organism
Thermococcus barophilus (strain DSM 11836 / MP)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei248 – 2481ATPUniRule annotation
    Active sitei250 – 2501N6-AMP-lysine intermediateUniRule annotation
    Binding sitei255 – 2551ATPUniRule annotation
    Binding sitei270 – 2701ATPUniRule annotation
    Binding sitei300 – 3001ATPUniRule annotation
    Binding sitei340 – 3401ATPUniRule annotation
    Binding sitei415 – 4151ATPUniRule annotation
    Binding sitei421 – 4211ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTBAR391623:GH3I-1995-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:TERMP_01956Imported
    OrganismiThermococcus barophilus (strain DSM 11836 / MP)Imported
    Taxonomic identifieri391623 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000007478: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF0LL23.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0LL23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLYKELAELY RRLEKTTLKT LKTRFVADFL KKVEDEELLE IVPYLILGKV    50
    FPDWDERELG VGEKLLIKAV AMATGINAEW IENSVKDTGD LGESVALALQ 100
    KRKQRSFFGQ PLTIKRVYKT LVKVAETTGE GSQDRKLKYL ANLFMDAEPI 150
    EGKYLARTIL GTMRTGVAEG LLRDAIAEAF RVKPELVERA YMLTSDFGFV 200
    TKIAKLEGNE GLSKVTIQIG KPIKPMLAQM AANVREALVE MGGEAEFEIK 250
    YDGARVQVHK DGDKVIIYSR RLENVTKSIP EVVERIKKSI KPEKAIVEGE 300
    LVAVGEGGRP RPFQYVLRRF RRKYNIQEMI EKIPLELNLF DVLYVDGENL 350
    IDTPFIERRK KLESIVEVNQ WIKVAENLIT KSPEEAEEFY HKALDMGHEG 400
    LMAKRLDSVY EPGNRGKKWL KIKPTMENLD LVIIGAEWGE GRRAHVLSSF 450
    LLGAYDPGTG TFVPVGKVGS GFTDEDLVEF TKMLKPLIKK EKGKFVEIEP 500
    KVVIEVTYQE IQKSPKYESG FALRFPRYVA LREDKSPEDA DTLERIAQLY 550
    ELQERMKAGK R 561
    Length:561
    Mass (Da):63,886
    Last modified:May 3, 2011 - v1
    Checksum:i1F16B32ED6C1A660
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002372 Genomic DNA. Translation: ADT84930.1.
    RefSeqiYP_004072153.1. NC_014804.1.

    Genome annotation databases

    EnsemblBacteriaiADT84930; ADT84930; TERMP_01956.
    GeneIDi10042271.
    KEGGitba:TERMP_01956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002372 Genomic DNA. Translation: ADT84930.1 .
    RefSeqi YP_004072153.1. NC_014804.1.

    3D structure databases

    ProteinModelPortali F0LL23.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADT84930 ; ADT84930 ; TERMP_01956 .
    GeneIDi 10042271.
    KEGGi tba:TERMP_01956.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci TBAR391623:GH3I-1995-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP."
      Vannier P., Marteinsson V.T., Fridjonsson O.H., Oger P., Jebbar M.
      J. Bacteriol. 193:1481-1482(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11836 / MPImported.

    Entry informationi

    Entry nameiF0LL23_THEBM
    AccessioniPrimary (citable) accession number: F0LL23
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3