Skip Header

Contribute Send feedback
Read comments (?) or add your own

F0LL23 (F0LL23_THEBM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407
EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:TERMP_01956 EMBL ADT84930.1
OrganismThermococcus barophilus (strain DSM 11836 / MP) [Complete proteome] [HAMAP]
Taxonomic identifier391623 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus ›

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2501N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2481ATP By similarity HAMAP-Rule MF_00407
Binding site2551ATP By similarity HAMAP-Rule MF_00407
Binding site2701ATP By similarity HAMAP-Rule MF_00407
Binding site3001ATP By similarity HAMAP-Rule MF_00407
Binding site3401ATP By similarity HAMAP-Rule MF_00407
Binding site4151ATP By similarity HAMAP-Rule MF_00407
Binding site4211ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
F0LL23 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 1F16B32ED6C1A660

FASTA56163,886
        10         20         30         40         50         60 
MLYKELAELY RRLEKTTLKT LKTRFVADFL KKVEDEELLE IVPYLILGKV FPDWDERELG 

        70         80         90        100        110        120 
VGEKLLIKAV AMATGINAEW IENSVKDTGD LGESVALALQ KRKQRSFFGQ PLTIKRVYKT 

       130        140        150        160        170        180 
LVKVAETTGE GSQDRKLKYL ANLFMDAEPI EGKYLARTIL GTMRTGVAEG LLRDAIAEAF 

       190        200        210        220        230        240 
RVKPELVERA YMLTSDFGFV TKIAKLEGNE GLSKVTIQIG KPIKPMLAQM AANVREALVE 

       250        260        270        280        290        300 
MGGEAEFEIK YDGARVQVHK DGDKVIIYSR RLENVTKSIP EVVERIKKSI KPEKAIVEGE 

       310        320        330        340        350        360 
LVAVGEGGRP RPFQYVLRRF RRKYNIQEMI EKIPLELNLF DVLYVDGENL IDTPFIERRK 

       370        380        390        400        410        420 
KLESIVEVNQ WIKVAENLIT KSPEEAEEFY HKALDMGHEG LMAKRLDSVY EPGNRGKKWL 

       430        440        450        460        470        480 
KIKPTMENLD LVIIGAEWGE GRRAHVLSSF LLGAYDPGTG TFVPVGKVGS GFTDEDLVEF 

       490        500        510        520        530        540 
TKMLKPLIKK EKGKFVEIEP KVVIEVTYQE IQKSPKYESG FALRFPRYVA LREDKSPEDA 

       550        560 
DTLERIAQLY ELQERMKAGK R

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic, piezophilic, heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP."
Vannier P., Marteinsson V.T., Fridjonsson O.H., Oger P., Jebbar M.
J. Bacteriol. 193:1481-1482(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11836 / MP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002372 Genomic DNA. Translation: ADT84930.1.
RefSeqYP_004072153.1. NC_014804.1.

3D structure databases

ProteinModelPortalF0LL23.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADT84930; ADT84930; TERMP_01956.
GeneID10042271.
KEGGtba:TERMP_01956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0LL23_THEBM
AccessionPrimary (citable) accession number: F0LL23
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 1, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info