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UniProtKB - F0LK16 (F0LK16_THEBM)

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Thermococcus barophilus (strain DSM 11836 / MP)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processCarbon dioxide fixationUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:TERMP_01753Imported
OrganismiThermococcus barophilus (strain DSM 11836 / MP)Imported
Taxonomic identifieri391623 [NCBI]
Taxonomic lineageiArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus ›
Proteomesi
  • UP000007478 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi391623.TERMP_01753.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04435. Archaea.
COG1892. LUCA.
HOGENOMiHOG000038601.
KOiK01595.
OMAiQSAFRYD.
OrthoDBiPOG093Z01LI.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2. 1 hit.
InterProiView protein in InterPro
IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
PfamiView protein in Pfam
PF14010. PEPcase_2. 1 hit.
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

F0LK16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPKTMSTQH PDNVYIPFFA REPQLGGEDE IIEAFYAFSV LGIEEQMWDF 
        60         70         80         90        100
EGKEVDEFVV KKLLERYPHF FRKHKLGEDF RLTPRVPNPS VEKAEAKLLL 
       110        120        130        140        150
ETLESISRSA DYSKIFYGKE IAPIFEVILP MTTSANEINR VYDLYKRYIV 
       160        170        180        190        200
GKQYKRVYDV KLYEWIGKFF PEEINVIPLF ETKDAILNSA EILREYLHGK 
       210        220        230        240        250
DFEYQRVFLA RSDPAMNYGL ISAVVYDKYA LFKLQELEEE ESVSIYPIIG 
       260        270        280        290        300
VGSAPFRGHL VPENVENVLE EYRGAQTFTI QSSFKYDNPP REVIKAVEKI 
       310        320        330        340        350
KSSKRKEAEP INGQILLILR KYEIEYSKQI KALAKLVREV AKFVPSRRKR 
       360        370        380        390        400
KLHIGLFGYA RDVNGFALPR AIKFTASLYS LGVPPEVLGL NALSEKDVEV 
       410        420        430        440        450
ISNVYNGIYK DLSLAFRYFN PKSAEKFKFL RDILKMSQLF EFERNEEHCE 
       460        470 
ITNKILDGEI NEELIIKAAS IRGFLG
Length:476
Mass (Da):55,184
Last modified:May 3, 2011 - v1
Checksum:i6F1B7A38A3A4F235
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002372 Genomic DNA. Translation: ADT84728.1.
RefSeqiWP_013468025.1. NC_014804.1.

Genome annotation databases

EnsemblBacteriaiADT84728; ADT84728; TERMP_01753.
GeneIDi10042069.
KEGGitba:TERMP_01753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002372 Genomic DNA. Translation: ADT84728.1.
RefSeqiWP_013468025.1. NC_014804.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391623.TERMP_01753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADT84728; ADT84728; TERMP_01753.
GeneIDi10042069.
KEGGitba:TERMP_01753.

Phylogenomic databases

eggNOGiarCOG04435. Archaea.
COG1892. LUCA.
HOGENOMiHOG000038601.
KOiK01595.
OMAiQSAFRYD.
OrthoDBiPOG093Z01LI.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2. 1 hit.
InterProiView protein in InterPro
IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
PfamiView protein in Pfam
PF14010. PEPcase_2. 1 hit.
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF0LK16_THEBM
AccessioniPrimary (citable) accession number: F0LK16
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 10, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.