F0LD63 (F0LD63_AGRSH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Urocanate hydratase HAMAP-Rule MF_00577
Short name=Urocanase HAMAP-Rule MF_00577
EC=4.2.1.49 HAMAP-Rule MF_00577

Alternative name(s):
Imidazolonepropionate hydrolase HAMAP-Rule MF_00577

Gene names

Name:	hutU HAMAP-Rule MF_00577
Ordered Locus Names:	AGROH133_12493 EMBL ADY67023.1

Organism

Agrobacterium sp. (strain H13-3) (Rhizobium lupini (strain H13-3)) [Complete proteome] [HAMAP] EMBL ADY67023.1

Taxonomic identifier

861208 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O. HAMAP-Rule MF_00577 SAAS SAAS023637
Cofactor	Binds 1 NAD per subunit By similarity. HAMAP-Rule MF_00577 SAAS SAAS023636
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3. HAMAP-Rule MF_00577 SAAS SAAS023637
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00577.
Sequence similarities	Belongs to the urocanase family. HAMAP-Rule MF_00577

Ontologies

Keywords
Biological process	Histidine metabolism HAMAP-Rule MF_00577 SAAS SAAS023637
Cellular component	Cytoplasm HAMAP-Rule MF_00577
Ligand	NAD HAMAP-Rule MF_00577 SAAS SAAS023637
Molecular function	Lyase HAMAP-Rule MF_00577 SAAS SAAS023637
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: UniProtKB-UniPathway histidine catabolic process to glutamate and formate Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	urocanate hydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	410	1	By similarity HAMAP-Rule MF_00577

Sequences

	Sequence		Length	Mass (Da)
	F0LD63 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 3454472C573D523D	FASTA	557	61,191
	10 20 30 40 50 60 MTNPRHNIRD VRAARGTELT AKSWMTEAPL RMLMNNLDPE VAENPHELVV YGGIGRAART 70 80 90 100 110 120 WADFDKIVAT LRDLNEDETL MVQSGKPVGV FRTHKDAPRV LIANSNLVPH WATWDHFNEL 130 140 150 160 170 180 DKKGLAMYGQ MTAGSWIYIG SQGIVQGTYE TFVEAGRQHY NGDLTGKWVL TGGLGGMGGA 190 200 210 220 230 240 QPLAAVMAGA CCLAIECNPD SIHFRLRTRY VDARAETLDE AMEMIERWTA AGEAKSVGLL 250 260 270 280 290 300 GNTAEILPEM VRRGIRPDMV TDQTSAHDPI NGYLPKGWTM AKWREKRESD PKAVEKAARA 310 320 330 340 350 360 SMREHVEAMI AFQDMGIPTF DYGNNIRQVA KEEGLENAFA FPGFVPAYIR PLFCRGVGPF 370 380 390 400 410 420 RWAALSGDPE DIRKTDAKVK ELLPDNKHLH NWLDMAAERI AFQGLPARIC WVGLGDRHRL 430 440 450 460 470 480 GLAFNEMVKN GELSAPIVIG RDHLDSGSVA SPNRETEAMQ DGSDAVSDWP LLNALLNTAS 490 500 510 520 530 540 GATWVSLHHG GGVGMGFSQH SGMVICCDGT DDAARRIERV LWNDPATGVM RHADAGYEIA 550 VECAKEQGLR LPGILGN

References

[1]

"Complete genome sequencing of Agrobacterium sp. H13-3, the former Rhizobium lupini H13-3, reveals a tripartite genome consisting of a circular and a linear chromosome and an accessory plasmid but lacking a tumor-inducing Ti-plasmid." Wibberg D., Blom J., Jaenicke S., Kollin F., Rupp O., Scharf B., Schneiker-Bekel S., Sczcepanowski R., Goesmann A., Setubal J.C., Schmitt R., Puhler A., Schluter A. J. Biotechnol. 155:50-62(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: H13-3 EMBL ADY67023.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002249 Genomic DNA. Translation: ADY67023.1.
RefSeq	YP_004444114.1. NC_015508.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADY67023; ADY67023; AGROH133_12493.
GeneID	10583003.
KEGG	agr:AGROH133_12493.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01712.
Enzyme and pathway databases
BioCyc	ASP861208:GH59-4078-MONOMER.
UniPathway	UPA00379; UER00550.
Family and domain databases
HAMAP	MF_00577. HutU.
InterPro	IPR023637. Urocanase. IPR023636. Urocanase_CS. [Graphical view]
PANTHER	PTHR32312. PTHR32312. 1 hit.
Pfam	PF01175. Urocanase. 1 hit. [Graphical view]
PIRSF	PIRSF001423. Urocanate_hydrat. 1 hit.
SUPFAM	SSF111326. Urocanase. 1 hit.
TIGRFAMs	TIGR01228. hutU. 1 hit.
PROSITE	PS01233. UROCANASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F0LD63_AGRSH

Accession

Primary (citable) accession number: F0LD63

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	May 29, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)