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Protein

Alanine racemase

Gene

alr

Organism
Agrobacterium sp. (strain H13-3) (Rhizobium lupini (strain H13-3))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (AGROH133_11117)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Active sitei271Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei330Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:AGROH133_05164Imported
OrganismiAgrobacterium sp. (strain H13-3) (Rhizobium lupini (strain H13-3))Imported
Taxonomic identifieri861208 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
Proteomesi
  • UP000007455 Componenti: Chromosome circular

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi861208.AGROH133_05164

Structurei

3D structure databases

ProteinModelPortaliF0L951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 387Ala_racemase_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OMAiCALHVDT
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

F0L951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDFEDTFP EHETDAFEHA PLRLTVDLGA LADNWRDMKK RSGKARTAAV
60 70 80 90 100
VKADAYGLGI EDCGATLYHA GARDFFVATV SEGATLRSYA PEARIFVLSG
110 120 130 140 150
IWQGQERQVF DNDLVPVLAS EEQLSFWMAT VAERGEHPCA LHVDTGFNRL
160 170 180 190 200
GLPLDDALFL ADDVTRPASF DPVLVLSHLA CADTPSSPMN KVQLESFRKV
210 220 230 240 250
SAAFEGIESS LSASAGIFLG PDYHFDLTRP GIALYGGEAI NDVANPMRPV
260 270 280 290 300
AKAEARIIQI REAGEGQTVS YGGTYLLKRA SRLAIASVGY ADGYQRSLSG
310 320 330 340 350
SGIPLREMGH GGAYGIVNGH KAPVAGRVTM DLTIFDITDI PANAVRTGDY
360 370 380 390
IELFGPKVPL DEVARAAGTI GYEMLTGLGL RYERQYLMAD D
Length:391
Mass (Da):42,228
Last modified:May 3, 2011 - v1
Checksum:i1DF5160D0E0ED862
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002248 Genomic DNA Translation: ADY64003.1
RefSeqiWP_013635829.1, NC_015183.1

Genome annotation databases

EnsemblBacteriaiADY64003; ADY64003; AGROH133_05164
KEGGiagr:AGROH133_05164

Similar proteinsi

Entry informationi

Entry nameiF0L951_AGRSH
AccessioniPrimary (citable) accession number: F0L951
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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