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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Yersinia enterocolitica subsp. palearctica serotype O:9 / biotype 3 (strain 105.5R(r))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA modification Source: InterPro
  2. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciYENT994476:GHRB-987-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotationSAAS annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:YE105_C0937Imported
OrganismiYersinia enterocolitica subsp. palearctica serotype O:9 / biotype 3 (strain 105.5R(r))Imported
Taxonomic identifieri994476 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000009271: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF0KYW8.
SMRiF0KYW8. Positions 9-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

KOiK03573.
OMAiLRPKGAN.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

F0KYW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVYSLPPAP PTDEHQLFQR AEALSGFTLG ELASKAGWNI PADLKRIKGW
60 70 80 90 100
VGMLLEFYLG ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL
110 120 130 140 150
TGNSGITWES SHVRHKLARV LWVPVEGERQ IPLAQRRVGA PLLWSPNEEE
160 170 180 190 200
EELLRRDWEE LMDLIVLGKV ETITARHGEV LQLRPKAANS RALTEAIGEH
210 220
GQPIMTLPRG FYLKKTFTGP MLARHFLL
Length:228
Mass (Da):25,322
Last modified:May 3, 2011 - v1
Checksum:iF08E3107D463E763
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002246 Genomic DNA. Translation: ADZ41433.1.
RefSeqiYP_004297136.1. NC_015224.1.

Genome annotation databases

EnsemblBacteriaiADZ41433; ADZ41433; YE105_C0937.
GeneIDi10300772.
KEGGiyep:YE105_C0937.
PATRICi47213515. VBIYerEnt184081_0985.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002246 Genomic DNA. Translation: ADZ41433.1.
RefSeqiYP_004297136.1. NC_015224.1.

3D structure databases

ProteinModelPortaliF0KYW8.
SMRiF0KYW8. Positions 9-228.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADZ41433; ADZ41433; YE105_C0937.
GeneIDi10300772.
KEGGiyep:YE105_C0937.
PATRICi47213515. VBIYerEnt184081_0985.

Phylogenomic databases

KOiK03573.
OMAiLRPKGAN.

Enzyme and pathway databases

BioCyciYENT994476:GHRB-987-MONOMER.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of a Yersinia enterocolitica "Old World" (3/O:9) strain and comparison with the "New World" (1B/O:8) strain."
    Wang X., Li Y., Jing H., Ren Y., Zhou Z., Wang S., Kan B., Xu J., Wang L.
    J. Clin. Microbiol. 49:1251-1259(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 105.5R(r)Imported.

Entry informationi

Entry nameiF0KYW8_YERE3
AccessioniPrimary (citable) accession number: F0KYW8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: February 4, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.