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Protein

Ribonuclease 3

Gene

rnc

Organism
Acinetobacter calcoaceticus (strain PHEA-2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461MagnesiumBy similarity
Active sitei50 – 501Sequence Analysis
Metal bindingi119 – 1191MagnesiumBy similarity
Active sitei122 – 1221By similarity
Metal bindingi122 – 1221MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciACAL871585:GH86-2013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:BDGL_001989
OrganismiAcinetobacter calcoaceticus (strain PHEA-2)
Taxonomic identifieri871585 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000007477 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Ribonuclease 3PRO_0000416603Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi871585.BDGL_001989.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 133124RNase IIIAdd
BLAST
Domaini161 – 23070DRBMAdd
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.Curated

Phylogenomic databases

KOiK03685.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0KKL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKHQFKLSD PRLLSRIGYQ FKQLELLQLA LTHRSVSHKY NYERLEFLGD
60 70 80 90 100
SLLGMIIANY LYHAYPNENE GRLTRMRATL VRQEALGKIA TDLQLSRCLI
110 120 130 140 150
LSTGELKSGG HHRESILADT VEAIIGAIYL DSGDLNLLKD IVLKWYIPYL
160 170 180 190 200
DHIEPTDQLK DPKSRLQEYL QARKKPLPVY EVVDIQGDAP HQHFKVECVV
210 220 230
DGLPKIYGEG SSRRFAEQAA AAEILKLLEQ
Length:230
Mass (Da):26,294
Last modified:April 18, 2012 - v2
Checksum:i05A6A4A29EFC98B8
GO

Sequence cautioni

The sequence ADY82575.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002177 Genomic DNA. Translation: ADY82575.1. Different initiation.
RefSeqiWP_014207368.1. NC_016603.1.
YP_004996257.1. NC_016603.1.

Genome annotation databases

EnsemblBacteriaiADY82575; ADY82575; BDGL_001989.
GeneIDi11640182.
KEGGiacc:BDGL_001989.
PATRICi47082101. VBIAciCal168233_1988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002177 Genomic DNA. Translation: ADY82575.1. Different initiation.
RefSeqiWP_014207368.1. NC_016603.1.
YP_004996257.1. NC_016603.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi871585.BDGL_001989.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADY82575; ADY82575; BDGL_001989.
GeneIDi11640182.
KEGGiacc:BDGL_001989.
PATRICi47082101. VBIAciCal168233_1988.

Phylogenomic databases

KOiK03685.

Enzyme and pathway databases

BioCyciACAL871585:GH86-2013-MONOMER.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Acinetobacter calcoaceticus PHEA-2, isolated from industry wastewater."
    Zhan Y., Yan Y., Zhang W., Yu H., Chen M., Lu W., Ping S., Peng Z., Yuan M., Zhou Z., Elmerich C., Lin M.
    J. Bacteriol. 193:2672-2673(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PHEA-2.

Entry informationi

Entry nameiRNC_ACICP
AccessioniPrimary (citable) accession number: F0KKL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: July 22, 2015
This is version 29 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.