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Protein

D-alanine--D-alanine ligase

Gene

ddlB

Organism
Acinetobacter calcoaceticus (strain PHEA-2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi255Magnesium or manganese 1UniRule annotation1
Metal bindingi268Magnesium or manganese 1UniRule annotation1
Metal bindingi268Magnesium or manganese 2UniRule annotation1
Metal bindingi270Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciACAL871585:G1GRU-2855-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlBImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:BDGL_002801Imported
OrganismiAcinetobacter calcoaceticus (strain PHEA-2)Imported
Taxonomic identifieri871585 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000007477 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi871585.BDGL_002801

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 301ATP-graspInterPro annotationAdd BLAST198

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
KOiK01921
OMAiMQGLLEC

Family and domain databases

HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 2 hits
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

F0KHC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNATKFGKV AVLFGGKSAE RAVSLDSGQA VLDALLRSGV QAEAFDPQDR
60 70 80 90 100
SVTELVNYDR AFIVLHGRGG EDGQIQGVLE WLNLPYTGTG VQGSAIGMDK
110 120 130 140 150
VKTKQIWQGS DLPTAPYRII TKETDLDAVI ADLGLPVIIK PVHEGSSVGM
160 170 180 190 200
SKVEKAEDFA AAIEKATQHD AVVMAEKWIT GREFTISFLN GQPLPVIRLQ
210 220 230 240 250
PPADVAFYDY EAKYQRNDVE YGIPCGLSEA EEKNLQALCL RAFQAVGAEG
260 270 280 290 300
WGRIDAMQDE QGNFWLLEVN TVPGMTSHSL VPKAAKAVGY SFDELCVAIL

EQTLEGTA
Length:308
Mass (Da):33,321
Last modified:May 3, 2011 - v1
Checksum:i807E8F53C8626281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002177 Genomic DNA Translation: ADY83387.1
RefSeqiWP_005066802.1, NC_016603.1
YP_004997069.1, NC_016603.1

Genome annotation databases

EnsemblBacteriaiADY83387; ADY83387; BDGL_002801
GeneIDi11637448
KEGGiacc:BDGL_002801
PATRICifig|871585.3.peg.2800

Similar proteinsi

Entry informationi

Entry nameiF0KHC6_ACICP
AccessioniPrimary (citable) accession number: F0KHC6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health