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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain 2038)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi298Magnesium or manganese 1UniRule annotation1
Metal bindingi312Magnesium or manganese 1UniRule annotation1
Metal bindingi312Magnesium or manganese 2UniRule annotation1
Metal bindingi314Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:LBU_0141Imported
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain 2038)Imported
Taxonomic identifieri353496 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000008126 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 345ATP-graspInterPro annotationAdd BLAST212

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01921.
OMAiYETKYTE.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

F0JYY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKTQVGLI FGGNSSEYEV SITSAGNIYK AIDKDKFDVH PIWITNSGYV
60 70 80 90 100
ASEADSYKVL EEPGYMVEKN DKTANLSNLI ELASRPELDV LFPIVHGNLG
110 120 130 140 150
EDGVLQGLFR LIDKPFVGVD VLAAAVTMDK EFTKILAQRA GVPVAKWVSI
160 170 180 190 200
KRYEYEDAKN QKLSYDWVSG QLGTSNLFVK PSNQGSSVGI THVTDDSNYA
210 220 230 240 250
EALAEAFKYD DKVLVEEGIV GTEVETAVLG NDHPVVSGVG QIINADNTWY
260 270 280 290 300
SYENKYSTES TTTLQIPAQI PAETAEKVQE NALKIYQITE CSGMARVDSM
310 320 330 340 350
LRESDGEVIF NELNALPGFT NISMYPKLFE EAGISYPDLI TRLIRLAEER
360
YAHKKTLLHK HD
Length:362
Mass (Da):40,079
Last modified:May 3, 2011 - v1
Checksum:iEA32580AA697DA87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000156 Genomic DNA. Translation: ADY84326.1.
RefSeqiWP_003621318.1. NC_017469.1.

Genome annotation databases

EnsemblBacteriaiADY84326; ADY84326; LBU_0141.
KEGGildl:LBU_0141.
PATRICifig|353496.3.peg.162.

Similar proteinsi

Entry informationi

Entry nameiF0JYY6_LACD2
AccessioniPrimary (citable) accession number: F0JYY6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 27, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported