Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F0JYY6 (F0JYY6_LACD2) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:LBU_0141 EMBL ADY84326.1
OrganismLactobacillus delbrueckii subsp. bulgaricus (strain 2038) [Complete proteome] [HAMAP] EMBL ADY84326.1
Taxonomic identifier353496 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain134 – 345212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding170 – 22556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2981Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3121Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3121Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F0JYY6 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: EA32580AA697DA87

FASTA36240,079
        10         20         30         40         50         60 
MTKKTQVGLI FGGNSSEYEV SITSAGNIYK AIDKDKFDVH PIWITNSGYV ASEADSYKVL 

        70         80         90        100        110        120 
EEPGYMVEKN DKTANLSNLI ELASRPELDV LFPIVHGNLG EDGVLQGLFR LIDKPFVGVD 

       130        140        150        160        170        180 
VLAAAVTMDK EFTKILAQRA GVPVAKWVSI KRYEYEDAKN QKLSYDWVSG QLGTSNLFVK 

       190        200        210        220        230        240 
PSNQGSSVGI THVTDDSNYA EALAEAFKYD DKVLVEEGIV GTEVETAVLG NDHPVVSGVG 

       250        260        270        280        290        300 
QIINADNTWY SYENKYSTES TTTLQIPAQI PAETAEKVQE NALKIYQITE CSGMARVDSM 

       310        320        330        340        350        360 
LRESDGEVIF NELNALPGFT NISMYPKLFE EAGISYPDLI TRLIRLAEER YAHKKTLLHK 


HD 

« Hide

References

[1]"Complete sequencing and pan-genomic analysis of Lactobacillus delbrueckii subsp. bulgaricus reveal its genetic basis for industrial yogurt production."
Hao P., Zheng H., Yu Y., Ding G., Gu W., Chen S., Yu Z., Ren S., Oda M., Konno T., Wang S., Li X., Ji Z.S., Zhao G.
PLoS ONE 6:E15964-E15964(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2038.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000156 Genomic DNA. Translation: ADY84326.1.
RefSeqYP_005851350.1. NC_017469.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADY84326; ADY84326; LBU_0141.
GeneID12459443.
KEGGldl:LBU_0141.
PATRIC47128317. VBILacDel183177_0162.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycLDEL353496:GLF6-147-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0JYY6_LACD2
AccessionPrimary (citable) accession number: F0JYY6
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: February 19, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)