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F0J6E1

- F0J6E1_ACIMA

UniProt

F0J6E1 - F0J6E1_ACIMA

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Protein

Alanine racemase

Gene

alr

Organism
Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei252 – 2521Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei300 – 3001Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAMUL926570:GI8V-3265-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:ACMV_32110Imported
OrganismiAcidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)Imported
Taxonomic identifieri926570 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000007100: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF0J6E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0J6E1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHPTLTIDP GAVAANWQAL AARHAGEVAG VVKADAYGLG AALIAPALAA
60 70 80 90 100
AGCRSFFVAT LDEALSLRAL LPAARIGVLN GCPPGEEETM RARELRPVLG
110 120 130 140 150
SLAACARWRG AAGDDEAPPS FLHLDTGMNR LGLDRDEAAH LIAHPTLLDG
160 170 180 190 200
LGLTHVMTHL VAAEEPDASA NAAQRERFAA FAARFPWLRT SLANSSGLFL
210 220 230 240 250
GPGFGSDLAR PGYALYGGNP TPTAANPMRP AIALAAPILQ IRAIASGETV
260 270 280 290 300
GYNGTWRAAR PSRIATIGVG YADGLPRSLS NRLTARWQGK IIPVAGRLSM
310 320 330 340 350
DLTTFDVTEH PDIAPGDVIE LIGPGHDIDA IAAEAGTIGY EILTSLGPRY

RRVVKSV
Length:357
Mass (Da):37,258
Last modified:May 3, 2011 - v1
Checksum:i5B639431682BF56F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012035 Genomic DNA. Translation: BAJ82558.1.
RefSeqiYP_004285440.1. NC_015186.1.

Genome annotation databases

EnsemblBacteriaiBAJ82558; BAJ82558; ACMV_32110.
GeneIDi10320184.
KEGGiamv:ACMV_32110.
PATRICi46815417. VBIAciMul178205_3637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012035 Genomic DNA. Translation: BAJ82558.1 .
RefSeqi YP_004285440.1. NC_015186.1.

3D structure databases

ProteinModelPortali F0J6E1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAJ82558 ; BAJ82558 ; ACMV_32110 .
GeneIDi 10320184.
KEGGi amv:ACMV_32110.
PATRICi 46815417. VBIAciMul178205_3637.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci AMUL926570:GI8V-3265-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Acidiphilium multivorum AIU301."
    Narita-Yamada S., Nakamura S., Ito N., Takarada H., Katano Y., Nakazawa H., Hosoyama A., Yamada R., Fujita N.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11245 / JCM 8867 / AIU301Imported.

Entry informationi

Entry nameiF0J6E1_ACIMA
AccessioniPrimary (citable) accession number: F0J6E1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3