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Protein

Alanine racemase

Gene

alr

Organism
Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / NBRC 100883 / AIU301)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Active sitei252Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei300Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:ACMV_32110Imported
OrganismiAcidiphilium multivorum (strain DSM 11245 / JCM 8867 / NBRC 100883 / AIU301)Imported
Taxonomic identifieri926570 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
Proteomesi
  • UP000007100 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliF0J6E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 355Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775.
OMAiISHFACA.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

F0J6E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHPTLTIDP GAVAANWQAL AARHAGEVAG VVKADAYGLG AALIAPALAA
60 70 80 90 100
AGCRSFFVAT LDEALSLRAL LPAARIGVLN GCPPGEEETM RARELRPVLG
110 120 130 140 150
SLAACARWRG AAGDDEAPPS FLHLDTGMNR LGLDRDEAAH LIAHPTLLDG
160 170 180 190 200
LGLTHVMTHL VAAEEPDASA NAAQRERFAA FAARFPWLRT SLANSSGLFL
210 220 230 240 250
GPGFGSDLAR PGYALYGGNP TPTAANPMRP AIALAAPILQ IRAIASGETV
260 270 280 290 300
GYNGTWRAAR PSRIATIGVG YADGLPRSLS NRLTARWQGK IIPVAGRLSM
310 320 330 340 350
DLTTFDVTEH PDIAPGDVIE LIGPGHDIDA IAAEAGTIGY EILTSLGPRY

RRVVKSV
Length:357
Mass (Da):37,258
Last modified:May 3, 2011 - v1
Checksum:i5B639431682BF56F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012035 Genomic DNA. Translation: BAJ82558.1.
RefSeqiWP_013641084.1. NZ_BANA01000011.1.

Genome annotation databases

EnsemblBacteriaiBAJ82558; BAJ82558; ACMV_32110.
KEGGiamv:ACMV_32110.

Similar proteinsi

Entry informationi

Entry nameiF0J6E1_ACIMA
AccessioniPrimary (citable) accession number: F0J6E1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported