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F0J6E1

- F0J6E1_ACIMA

UniProt

F0J6E1 - F0J6E1_ACIMA

Protein

Alanine racemase

Gene

alr

Organism
Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei130 – 1301SubstrateUniRule annotation
    Active sitei252 – 2521Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei300 – 3001Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciAMUL926570:GI8V-3265-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:ACMV_32110Imported
    OrganismiAcidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)Imported
    Taxonomic identifieri926570 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
    ProteomesiUP000007100: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF0J6E1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0J6E1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHPTLTIDP GAVAANWQAL AARHAGEVAG VVKADAYGLG AALIAPALAA    50
    AGCRSFFVAT LDEALSLRAL LPAARIGVLN GCPPGEEETM RARELRPVLG 100
    SLAACARWRG AAGDDEAPPS FLHLDTGMNR LGLDRDEAAH LIAHPTLLDG 150
    LGLTHVMTHL VAAEEPDASA NAAQRERFAA FAARFPWLRT SLANSSGLFL 200
    GPGFGSDLAR PGYALYGGNP TPTAANPMRP AIALAAPILQ IRAIASGETV 250
    GYNGTWRAAR PSRIATIGVG YADGLPRSLS NRLTARWQGK IIPVAGRLSM 300
    DLTTFDVTEH PDIAPGDVIE LIGPGHDIDA IAAEAGTIGY EILTSLGPRY 350
    RRVVKSV 357
    Length:357
    Mass (Da):37,258
    Last modified:May 3, 2011 - v1
    Checksum:i5B639431682BF56F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012035 Genomic DNA. Translation: BAJ82558.1.
    RefSeqiYP_004285440.1. NC_015186.1.

    Genome annotation databases

    EnsemblBacteriaiBAJ82558; BAJ82558; ACMV_32110.
    GeneIDi10320184.
    KEGGiamv:ACMV_32110.
    PATRICi46815417. VBIAciMul178205_3637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012035 Genomic DNA. Translation: BAJ82558.1 .
    RefSeqi YP_004285440.1. NC_015186.1.

    3D structure databases

    ProteinModelPortali F0J6E1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAJ82558 ; BAJ82558 ; ACMV_32110 .
    GeneIDi 10320184.
    KEGGi amv:ACMV_32110.
    PATRICi 46815417. VBIAciMul178205_3637.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci AMUL926570:GI8V-3265-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Acidiphilium multivorum AIU301."
      Narita-Yamada S., Nakamura S., Ito N., Takarada H., Katano Y., Nakazawa H., Hosoyama A., Yamada R., Fujita N.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11245 / JCM 8867 / AIU301Imported.

    Entry informationi

    Entry nameiF0J6E1_ACIMA
    AccessioniPrimary (citable) accession number: F0J6E1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3