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F0J4D4

- F0J4D4_ACIMA

UniProt

F0J4D4 - F0J4D4_ACIMA

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Binding sitei259 – 2591NADP
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
    Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi309 – 3146NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciAMUL926570:GI8V-648-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:ACMV_06390Imported
    OrganismiAcidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)Imported
    Taxonomic identifieri926570 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
    ProteomesiUP000007100: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF0J4D4.
    SMRiF0J4D4. Positions 3-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F0J4D4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVKNPI VEMDGDEMTR IIWGFIKDKL ILPYLDVDLK YYDLGIENRD    50
    ATDDKVTVDS ALATKEYGVA VKCATITPDE ARVKEFNLKQ MWRSPNGTIR 100
    NILDGTIFRE PIICANVPRL VPHWSQPIVI GRHAYGDIYR AAETKIPGPG 150
    KVQLSYIPAD GSKPLILDVH DFKGPGVALG IHNTKASIEG FARASFNYGL 200
    ARNYPVYLST KNTILKAYDG MFKDVFQEIF DAEFKAEFDK RGLTYEHRLI 250
    DDMVASALKW NGGYIWACKN YDGDVESDIV AQGFGSLGLM TSVLMSPDGK 300
    TVESEAAHGT VTRHYREHQK GRPTSTNPIA SIFAWTRGLA YRGKFDETPE 350
    VTEFAETLER VCVETVESGF MTKDLALLIS KDQPWMTTQD FLAKLDENLQ 400
    AAMAKRQAA 409
    Length:409
    Mass (Da):45,768
    Last modified:May 3, 2011 - v1
    Checksum:i3A7D7CE33505DAEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012035 Genomic DNA. Translation: BAJ79986.1.
    RefSeqiYP_004282868.1. NC_015186.1.

    Genome annotation databases

    EnsemblBacteriaiBAJ79986; BAJ79986; ACMV_06390.
    GeneIDi10318398.
    KEGGiamv:ACMV_06390.
    PATRICi46810017. VBIAciMul178205_1000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012035 Genomic DNA. Translation: BAJ79986.1 .
    RefSeqi YP_004282868.1. NC_015186.1.

    3D structure databases

    ProteinModelPortali F0J4D4.
    SMRi F0J4D4. Positions 3-406.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAJ79986 ; BAJ79986 ; ACMV_06390 .
    GeneIDi 10318398.
    KEGGi amv:ACMV_06390.
    PATRICi 46810017. VBIAciMul178205_1000.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci AMUL926570:GI8V-648-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Acidiphilium multivorum AIU301."
      Narita-Yamada S., Nakamura S., Ito N., Takarada H., Katano Y., Nakazawa H., Hosoyama A., Yamada R., Fujita N.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11245 / JCM 8867 / AIU301Imported.

    Entry informationi

    Entry nameiF0J4D4_ACIMA
    AccessioniPrimary (citable) accession number: F0J4D4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3