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F0J4D4 (F0J4D4_ACIMA) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd EMBL BAJ79986.1
Ordered Locus Names:ACMV_06390 EMBL BAJ79986.1
OrganismAcidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301) [Complete proteome] [HAMAP] EMBL BAJ79986.1
Taxonomic identifier926570 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding309 – 3146NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity
Metal binding2741Magnesium or manganese By similarity
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2591NADP By similarity PIRSR PIRSR000108-4
Binding site3271NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
F0J4D4 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 3A7D7CE33505DAEC

FASTA40945,768
        10         20         30         40         50         60 
MAKIKVKNPI VEMDGDEMTR IIWGFIKDKL ILPYLDVDLK YYDLGIENRD ATDDKVTVDS 

        70         80         90        100        110        120 
ALATKEYGVA VKCATITPDE ARVKEFNLKQ MWRSPNGTIR NILDGTIFRE PIICANVPRL 

       130        140        150        160        170        180 
VPHWSQPIVI GRHAYGDIYR AAETKIPGPG KVQLSYIPAD GSKPLILDVH DFKGPGVALG 

       190        200        210        220        230        240 
IHNTKASIEG FARASFNYGL ARNYPVYLST KNTILKAYDG MFKDVFQEIF DAEFKAEFDK 

       250        260        270        280        290        300 
RGLTYEHRLI DDMVASALKW NGGYIWACKN YDGDVESDIV AQGFGSLGLM TSVLMSPDGK 

       310        320        330        340        350        360 
TVESEAAHGT VTRHYREHQK GRPTSTNPIA SIFAWTRGLA YRGKFDETPE VTEFAETLER 

       370        380        390        400 
VCVETVESGF MTKDLALLIS KDQPWMTTQD FLAKLDENLQ AAMAKRQAA 

« Hide

References

[1]"Whole genome sequence of Acidiphilium multivorum AIU301."
Narita-Yamada S., Nakamura S., Ito N., Takarada H., Katano Y., Nakazawa H., Hosoyama A., Yamada R., Fujita N.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11245 / JCM 8867 / AIU301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP012035 Genomic DNA. Translation: BAJ79986.1.
RefSeqYP_004282868.1. NC_015186.1.

3D structure databases

ProteinModelPortalF0J4D4.
SMRF0J4D4. Positions 3-406.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAJ79986; BAJ79986; ACMV_06390.
GeneID10318398.
KEGGamv:ACMV_06390.
PATRIC46810017. VBIAciMul178205_1000.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycAMUL926570:GI8V-648-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF0J4D4_ACIMA
AccessionPrimary (citable) accession number: F0J4D4
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 16, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)