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F0J4D4

- F0J4D4_ACIMA

UniProt

F0J4D4 - F0J4D4_ACIMA

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADP
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Binding sitei259 – 2591NADP
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation
Binding sitei327 – 3271NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP
Nucleotide bindingi309 – 3146NADP

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAMUL926570:GI8V-648-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:ACMV_06390Imported
OrganismiAcidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)Imported
Taxonomic identifieri926570 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000007100: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF0J4D4.
SMRiF0J4D4. Positions 3-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F0J4D4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVKNPI VEMDGDEMTR IIWGFIKDKL ILPYLDVDLK YYDLGIENRD
60 70 80 90 100
ATDDKVTVDS ALATKEYGVA VKCATITPDE ARVKEFNLKQ MWRSPNGTIR
110 120 130 140 150
NILDGTIFRE PIICANVPRL VPHWSQPIVI GRHAYGDIYR AAETKIPGPG
160 170 180 190 200
KVQLSYIPAD GSKPLILDVH DFKGPGVALG IHNTKASIEG FARASFNYGL
210 220 230 240 250
ARNYPVYLST KNTILKAYDG MFKDVFQEIF DAEFKAEFDK RGLTYEHRLI
260 270 280 290 300
DDMVASALKW NGGYIWACKN YDGDVESDIV AQGFGSLGLM TSVLMSPDGK
310 320 330 340 350
TVESEAAHGT VTRHYREHQK GRPTSTNPIA SIFAWTRGLA YRGKFDETPE
360 370 380 390 400
VTEFAETLER VCVETVESGF MTKDLALLIS KDQPWMTTQD FLAKLDENLQ

AAMAKRQAA
Length:409
Mass (Da):45,768
Last modified:May 3, 2011 - v1
Checksum:i3A7D7CE33505DAEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012035 Genomic DNA. Translation: BAJ79986.1.
RefSeqiYP_004282868.1. NC_015186.1.

Genome annotation databases

EnsemblBacteriaiBAJ79986; BAJ79986; ACMV_06390.
GeneIDi10318398.
KEGGiamv:ACMV_06390.
PATRICi46810017. VBIAciMul178205_1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012035 Genomic DNA. Translation: BAJ79986.1 .
RefSeqi YP_004282868.1. NC_015186.1.

3D structure databases

ProteinModelPortali F0J4D4.
SMRi F0J4D4. Positions 3-406.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAJ79986 ; BAJ79986 ; ACMV_06390 .
GeneIDi 10318398.
KEGGi amv:ACMV_06390.
PATRICi 46810017. VBIAciMul178205_1000.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci AMUL926570:GI8V-648-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Acidiphilium multivorum AIU301."
    Narita-Yamada S., Nakamura S., Ito N., Takarada H., Katano Y., Nakazawa H., Hosoyama A., Yamada R., Fujita N.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11245 / JCM 8867 / AIU301Imported.

Entry informationi

Entry nameiF0J4D4_ACIMA
AccessioniPrimary (citable) accession number: F0J4D4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3