E9VDS6 (E9VDS6_ECOLX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Fe/S biogenesis protein NfuA HAMAP-Rule MF_01637

Gene names

Name:	nfuA HAMAP-Rule MF_01637
ORF Names:	ERKG_03480 EMBL EGB45954.1

Organism

Escherichia coli H252 EMBL EGB45954.1

Taxonomic identifier

656388 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins By similarity. HAMAP-Rule MF_01637 SAAS SAAS001075
Cofactor	Binds 1 4Fe-4S cluster per subunit. The cluster is presumably bound at the interface of two monomers By similarity. HAMAP-Rule MF_01637 SAAS SAAS001075
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01637 SAAS SAAS001075
Sequence similarities	Belongs to the NfuA family. HAMAP-Rule MF_01637
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL EGB45954.1

Ontologies

Keywords
Ligand	4Fe-4S HAMAP-Rule MF_01637 SAAS SAAS001075 Iron Iron-sulfur Metal-binding
Gene Ontology (GO)
Biological_process	iron-sulfur cluster assembly Inferred from electronic annotation. Source: HAMAP protein maturation Inferred from electronic annotation. Source: HAMAP
Molecular_function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	149	1	Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_01637
	Metal binding	152	1	Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_01637

Sequences

	Sequence		Length	Mass (Da)
	E9VDS6 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 06874546ADA5A971	FASTA	191	20,998
	10 20 30 40 50 60 MIRISDAAQA HFAKLLANQE EGTQIRVFVI NPGTPNAECG VSYCPPDAVE ATDTALKFDL 70 80 90 100 110 120 LTAYVDELSA PYLEDAEIDF VTDQLGSQLT LKAPNAKMRK VADDAPLMER VEYMLQSQIN 130 140 150 160 170 180 PQLAGHGGRV SLMEITEDGY AILQFGGGCN GCSMVDVTLK EGIEKQLLNE FPELKGVRDL 190 TEHQRGEHSY Y

References

[1]

"The Genome Sequence of Escherichia coli strain H252." The Broad Institute Genome Sequencing Platform Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D. , Howarth C., Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C., Birren B. Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: H252 EMBL EGB45954.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AEFI01000019 Genomic DNA. Translation: EGB45954.1.
3D structure databases
ProteinModelPortal	E9VDS6.
SMR	E9VDS6. Positions 2-99, 106-186.
ModBase	Search...
Proteomic databases
PRIDE	E9VDS6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EGB45954; EGB45954; ERKG_03480.
PATRIC	47958788. VBIEscCol162925_3665.
Phylogenomic databases
OMA	CQGCSAV.
Family and domain databases
Gene3D	2.60.300.12. 1 hit.
HAMAP	MF_01637. Fe_S_biogen_NfuA.
InterPro	IPR017726. Fe/S_biogenesis_protein_NfuA. IPR000361. FeS_biogenesis. IPR001075. NIF_FeS_clus_asmbl_NifU_C. [Graphical view]
Pfam	PF01521. Fe-S_biosyn. 1 hit. PF01106. NifU. 1 hit. [Graphical view]
ProDom	PD002830. NIF_FeS_clus_asmbl_NifU_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF89360. HesB_yadR_yfhF-like. 1 hit.
TIGRFAMs	TIGR03341. YhgI_GntY. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E9VDS6_ECOLX

Accession

Primary (citable) accession number: E9VDS6

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)