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Protein
Submitted name:

E3 ubiquitin-protein ligase SH3RF1

Gene

Sh3rf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase SH3RF1Imported
Gene namesi
Name:Sh3rf1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913066. Sh3rf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiE9QQ33.
PRIDEiE9QQ33.

Expressioni

Gene expression databases

BgeeiE9QQ33.
GenevisibleiE9QQ33. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034060.

Structurei

3D structure databases

ProteinModelPortaliE9QQ33.
SMRiE9QQ33. Positions 5-78, 137-255, 456-511, 838-891.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 5342RING-typeInterPro annotationAdd
BLAST
Domaini134 – 19360SH3InterPro annotationAdd
BLAST
Domaini196 – 25964SH3InterPro annotationAdd
BLAST
Domaini451 – 51262SH3InterPro annotationAdd
BLAST
Domaini838 – 89154SH3InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 4 SH3 domains.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation, Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITG6. Eukaryota.
ENOG410XS5R. LUCA.
GeneTreeiENSGT00760000119190.
KOiK12171.
OMAiCTNALRA.
OrthoDBiEOG7HMS0X.
TreeFamiTF105571.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028502. POSH1.
IPR001452. SH3_domain.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR10663:SF153. PTHR10663:SF153. 5 hits.
PfamiPF00018. SH3_1. 1 hit.
PF14604. SH3_9. 3 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 4 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 4 hits.
PROSITEiPS50002. SH3. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QQ33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP
60 70 80 90 100
ECRTLVGSGV DELPSNILLV RLLDGIKQRP WKPGPGGGGG TTCTNTLRAQ
110 120 130 140 150
GSTVVNCGSK DLQSSQCGQQ PRVQAWSPPV RGIPQLPCAK ALYNYEGKEP
160 170 180 190 200
GDLKFSKGDI IILRRQVDEN WYHGEVSGVH GFFPTNFVQI IKPLPQPPPQ
210 220 230 240 250
CKALYDFEVK DKEADKDCLP FAKDDVLTVI RRVDENWAEG MLADKIGIFP
260 270 280 290 300
ISYVEFNSAA KQLIEWDKPP VPGVDTAECP SATAQSTSAS KHPDTKKNTR
310 320 330 340 350
KRHSFTSLTM ANKSSQGSQN RHSMEISPPV LISSSNPTAA ARISELSGLS
360 370 380 390 400
CSAPSQVHIS TTGLIVTPPP SSPVTTGPAF TFPSDVPYQA ALGSMNPPLP
410 420 430 440 450
PPPLLAATVL ASTPSGATAA VAAAAAAAAA GMGPRPVMGS SEQIAHLRPQ
460 470 480 490 500
TRPSVYVAIY PYTPRKEDEL ELRKGEMFLV FERCQDGWYK GTSMHTSKIG
510 520 530 540 550
VFPGNYVAPV TRAVTNASQA KVSMSTAGQA SRGVTMVSPS TAGGPTQKPQ
560 570 580 590 600
GNGVAGNPSV VPTAVVSAAH IQTSPQAKVL LHMSGQMTVN QARNAVRTVA
610 620 630 640 650
AHSQERPTAA VTPIQVQNAA CLGPASVGLP HHSLASQPLP PMAGPAAHGA
660 670 680 690 700
AVSISRTNAP MACAAGASLA SPNMTSAVLE TEPSGRTVTI LPGLPTSPES
710 720 730 740 750
AASACGNSSA GKPDKDSKKE KKGLLKLLSG ASTKRKPRVS PPASPTLDVE
760 770 780 790 800
LGAGEAPLQG AVGPELPLGG SHGRVGSCPT DGDGPVAAGT AALAQDAFHR
810 820 830 840 850
KTSSLDSAVP IAPPPRQACS SLGPVMNEAR PVVCERHRVV VSYPPQSEAE
860 870 880 890
LELKEGDIVF VHKKREDGWF KGTLQRNGKT GLFPGSFVEN I
Length:891
Mass (Da):93,344
Last modified:April 5, 2011 - v1
Checksum:i4D41D16DEA0B1159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117196 Genomic DNA. No translation available.
AC134339 Genomic DNA. No translation available.
RefSeqiNP_067481.2. NM_021506.2.
UniGeneiMm.27949.

Genome annotation databases

EnsembliENSMUST00000034060; ENSMUSP00000034060; ENSMUSG00000031642.
GeneIDi59009.
KEGGimmu:59009.
UCSCiuc009ltw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117196 Genomic DNA. No translation available.
AC134339 Genomic DNA. No translation available.
RefSeqiNP_067481.2. NM_021506.2.
UniGeneiMm.27949.

3D structure databases

ProteinModelPortaliE9QQ33.
SMRiE9QQ33. Positions 5-78, 137-255, 456-511, 838-891.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034060.

Proteomic databases

PaxDbiE9QQ33.
PRIDEiE9QQ33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034060; ENSMUSP00000034060; ENSMUSG00000031642.
GeneIDi59009.
KEGGimmu:59009.
UCSCiuc009ltw.1. mouse.

Organism-specific databases

CTDi57630.
MGIiMGI:1913066. Sh3rf1.

Phylogenomic databases

eggNOGiENOG410ITG6. Eukaryota.
ENOG410XS5R. LUCA.
GeneTreeiENSGT00760000119190.
KOiK12171.
OMAiCTNALRA.
OrthoDBiEOG7HMS0X.
TreeFamiTF105571.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiSh3rf1. mouse.
NextBioi314548.
SOURCEiSearch...

Gene expression databases

BgeeiE9QQ33.
GenevisibleiE9QQ33. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028502. POSH1.
IPR001452. SH3_domain.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR10663:SF153. PTHR10663:SF153. 5 hits.
PfamiPF00018. SH3_1. 1 hit.
PF14604. SH3_9. 3 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00184. RING. 1 hit.
SM00326. SH3. 4 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 4 hits.
PROSITEiPS50002. SH3. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QQ33_MOUSE
AccessioniPrimary (citable) accession number: E9QQ33
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.