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Protein

Tyrosine-protein kinase receptor

Gene

Igf1r

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1137Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-MMU-2428928 IRS-related events triggered by IGF1R
R-MMU-2428933 SHC-related events triggered by IGF1R

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Igf1rImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96433 Igf1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei934 – 959HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500324482631 – 1369Tyrosine-protein kinase receptorSequence analysisAdd BLAST1339

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

MaxQBiE9QNX9
PeptideAtlasiE9QNX9
PRIDEiE9QNX9

Expressioni

Gene expression databases

BgeeiENSMUSG00000005533
GenevisibleiE9QNX9 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9QNX9
SMRiE9QNX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini490 – 610Fibronectin type-IIIInterPro annotationAdd BLAST121
Domaini611 – 709Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini735 – 829Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini835 – 928Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1000 – 1276Protein kinaseInterPro annotationAdd BLAST277

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili705 – 725Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4258 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118818
KOiK05087
OMAiGYLYRHN
OrthoDBiEOG091G00GE
TreeFamiTF351636

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 2 hits
3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016246 Tyr_kinase_insulin-like_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PIRSFiPIRSF000620 Insulin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00261 FU, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 4 hits
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

E9QNX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSGSGGGSP TSLWGLVFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE
60 70 80 90 100
NCTVIEGFLH ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF
110 120 130 140 150
PNLTVIRGWK LFYNYALVIF EMTNLKDIGL YNLRNITRGA IRIEKNADLC
160 170 180 190 200
YLSTIDWSLI LDAVSNNYIV GNKPPKECGD LCPGTLEEKP MCEKTTINNE
210 220 230 240 250
YNYRCWTTNR CQKMCPSVCG KRACTENNEC CHPECLGSCH TPDDNTTCVA
260 270 280 290 300
CRHYYYKGVC VPACPPGTYR FEGWRCVDRD FCANIPNAES SDSDGFVIHD
310 320 330 340 350
DECMQECPSG FIRNSTQSMY CIPCEGPCPK VCGDEEKKTK TIDSVTSAQM
360 370 380 390 400
LQGCTILKGN LLINIRRGNN IASELENFMG LIEVVTGYVK IRHSHALVSL
410 420 430 440 450
SFLKNLRLIL GEEQLEGNYS FYVLDNQNLQ QLWDWNHRNL TVRSGKMYFA
460 470 480 490 500
FNPKLCVSEI YRMEEVTGTK GRQSKGDINT RNNGERASCE SDVLRFTSTT
510 520 530 540 550
TWKNRIIITW HRYRPPDYRD LISFTVYYKE APFKNVTEYD GQDACGSNSW
560 570 580 590 600
NMVDVDLPPN KEGEPGILLH GLKPWTQYAV YVKAVTLTMV ENDHIRGAKS
610 620 630 640 650
EILYIRTNAS VPSIPLDVLS ASNSSSQLIV KWNPPTLPNG NLSYYIVRWQ
660 670 680 690 700
RQPQDGYLYR HNYCSKDKIP IRKYADGTID VEEVTENPKT EVCGGDKGPC
710 720 730 740 750
CACPKTEAEK QAEKEEAEYR KVFENFLHNS IFVPRPERRR RDVMQVANTT
760 770 780 790 800
MSSRSRNTTV ADTYNITDPE EFETEYPFFE SRVDNKERTV ISNLRPFTLY
810 820 830 840 850
RIDIHSCNHE AEKLGCSASN FVFARTMPAE GADDIPGPVT WEPRPENSIF
860 870 880 890 900
LKWPEPENPN GLILMYEIKY GSQVEDQREC VSRQEYRKYG GAKLNRLNPG
910 920 930 940 950
NYTARIQATS LSGNGSWTDP VFFYVPAKTT YENFMHLIIA LPVAILLIVG
960 970 980 990 1000
GLVIMLYVFH RKRNNSRLGN GVLYASVNPE YFSAADVYVP DEWEVAREKI
1010 1020 1030 1040 1050
TMNRELGQGS FGMVYEGVAK GVVKDEPETR VAIKTVNEAA SMRERIEFLN
1060 1070 1080 1090 1100
EASVMKEFNC HHVVRLLGVV SQGQPTLVIM ELMTRGDLKS YLRSLRPEVE
1110 1120 1130 1140 1150
QNNLVLIPPS LSKMIQMAGE IADGMAYLNA NKFVHRDLAA RNCMVAEDFT
1160 1170 1180 1190 1200
VKIGDFGMTR DIYETDYYRK GGKGLLPVRW MSPESLKDGV FTTHSDVWSF
1210 1220 1230 1240 1250
GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLDKPDNCP DMLFELMRMC
1260 1270 1280 1290 1300
WQYNPKMRPS FLEIIGSIKD EMEPSFQEVS FYYSEENKPP EPEELEMEPE
1310 1320 1330 1340 1350
NMESVPLDPS ASSASLPLPE RHSGHKAENG PGPGVLVLRA SFDERQPYAH
1360
MNGGRANERA LPLPQSSTC
Length:1,369
Mass (Da):155,286
Last modified:April 5, 2011 - v1
Checksum:iF8739A91D09706E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101879 Genomic DNA No translation available.
AC101986 Genomic DNA No translation available.
AC158574 Genomic DNA No translation available.
AC158584 Genomic DNA No translation available.
RefSeqiNP_034643.2, NM_010513.2
UniGeneiMm.275742

Genome annotation databases

EnsembliENSMUST00000005671; ENSMUSP00000005671; ENSMUSG00000005533
GeneIDi16001
KEGGimmu:16001
UCSCiuc009hja.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QNX9_MOUSE
AccessioniPrimary (citable) accession number: E9QNX9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health