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E9QNJ9 (E9QNJ9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length802 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS013098 PIRNR PIRNR000628

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. PIRNR PIRNR000628

Contains protein kinase domain. SAAS SAAS013098

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000131845 Ensembl ENSMUSP00000110053

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain SAAS SAAS013151 RuleBase RU003326
Repeat SAAS SAAS013098
Transmembrane
Transmembrane helix SAAS SAAS013098
   LigandATP-binding SAAS SAAS013098 PIRNR PIRNR000628
Nucleotide-binding
   Molecular functionKinase
Receptor SAAS SAAS013098 PIRNR PIRNR000628
Transferase
Tyrosine-protein kinase SAAS SAAS013098 PIRNR PIRNR000628
   PTMDisulfide bond SAAS SAAS013151
Phosphoprotein SAAS SAAS020635
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from direct assay PubMed 14699054. Source: MGI

alveolar secondary septum development

Inferred from genetic interaction PubMed 9716527. Source: MGI

axonogenesis involved in innervation

Inferred from mutant phenotype PubMed 17557302. Source: MGI

bone morphogenesis

Inferred from mutant phenotype PubMed 19407216. Source: MGI

cartilage development

Inferred from mutant phenotype PubMed 15781473. Source: MGI

cell differentiation

Inferred from mutant phenotype PubMed 17557302. Source: MGI

central nervous system myelination

Inferred from mutant phenotype PubMed 12574417. Source: MGI

cochlea development

Inferred from mutant phenotype PubMed 17557302. Source: MGI

digestive tract morphogenesis

Inferred from mutant phenotype PubMed 19407216. Source: MGI

epithelial cell fate commitment

Inferred from mutant phenotype PubMed 19407216. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from direct assay PubMed 14699054. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 15708559. Source: MGI

inner ear development

Inferred from mutant phenotype PubMed 17117437. Source: MGI

inner ear receptor cell differentiation

Inferred from mutant phenotype PubMed 17117437. Source: MGI

lens fiber cell development

Inferred from genetic interaction PubMed 18455718. Source: MGI

lens morphogenesis in camera-type eye

Inferred from mutant phenotype PubMed 11290300. Source: MGI

morphogenesis of an epithelium

Inferred from mutant phenotype PubMed 17117437. Source: MGI

negative regulation of astrocyte differentiation

Inferred from mutant phenotype PubMed 12574417. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 15708559. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 11290300PubMed 17192470. Source: MGI

negative regulation of mitosis

Inferred from genetic interaction PubMed 18455718. Source: MGI

negative regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 9811582. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 9811582. Source: MGI

oligodendrocyte development

Inferred from mutant phenotype PubMed 12574417. Source: MGI

positive regulation of MAPK cascade

Inferred from mutant phenotype PubMed 11290300. Source: MGI

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction PubMed 18187602. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 19407216. Source: MGI

positive regulation of cell differentiation

Inferred from mutant phenotype PubMed 12417662PubMed 17117437. Source: MGI

positive regulation of cell proliferation

Inferred from genetic interaction PubMed 18187602. Source: MGI

positive regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 16291864. Source: MGI

positive regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 15708559. Source: MGI

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 14699054. Source: MGI

positive regulation of protein ubiquitination

Inferred from direct assay PubMed 14699054. Source: MGI

response to axon injury

Inferred from mutant phenotype PubMed 16009496. Source: MGI

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 19407216. Source: MGI

substantia nigra development

Inferred from mutant phenotype PubMed 17234579. Source: MGI

   Cellular_componentcytoplasmic side of plasma membrane

Inferred from direct assay PubMed 14699054. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosome

Inferred from direct assay PubMed 14699054. Source: MGI

perinuclear region of cytoplasm

Inferred from direct assay PubMed 14699054. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

fibroblast growth factor-activated receptor activity

Inferred from direct assay PubMed 14699054. Source: MGI

protein binding

Inferred from physical interaction PubMed 16436388. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site6131Proton acceptor By similarity PIRSR PIRSR000628-1

Sequences

Sequence LengthMass (Da)Tools
E9QNJ9 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 6DADCB5A2F20731F

FASTA80288,165
        10         20         30         40         50         60 
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG SGDTVELSCH 

        70         80         90        100        110        120 
PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE DAGVYSCQHR LTRRVLCHFS 

       130        140        150        160        170        180 
VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP ERMDKKLLAV PAANTVRFRC PAAGNPTPSI 

       190        200        210        220        230        240 
SWLKNGKEFR GEHRIGGIKL RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL 

       250        260        270        280        290        300 
ERSPHRPILQ AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYV 

       310        320        330        340        350        360 
TVLKSWISEN VEADARLRLA NVSERDGGEY LCRATNFIGV AEKAFWLRVH GPQAAEEELM 

       370        380        390        400        410        420 
ETDEAGSVYA GVLSYGVVFF LFILVVAAVI LCRLRSPPKK GLGSPTVHKV SRFPLKRQVS 

       430        440        450        460        470        480 
LESNSSMNSN TPLVRIARLS SGEGPVLANV SELELPADPK WELSRTRLTL GKPLGEGCFG 

       490        500        510        520        530        540 
QVVMAEAIGI DKDRTAKPVT VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA 

       550        560        570        580        590        600 
CTQGGPLYVL VEYAAKGNLR EFLRARRPPG MDYSFDACRL PEEQLTCKDL VSCAYQVARG 

       610        620        630        640        650        660 
MEYLASQKCI HRDLAARNVL VTEDNVMKIA DFGLARDVHN LDYYKKTTNG RLPVKWMAPE 

       670        680        690        700        710        720 
ALFDRVYTHQ SDVWSFGVLL WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPASCTHDLY 

       730        740        750        760        770        780 
MIMRECWHAV PSQRPTFKQL VEDLDRILTV TSTDEYLDLS VPFEQYSPGG QDTPSSSSSG 

       790        800 
DDSVFTHDLL PPGPPSNGGP RT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC162898 Genomic DNA. No translation available.
RefSeqNP_001156689.1. NM_001163217.2.
XP_006503791.1. XM_006503728.1.
UniGeneMm.6904.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000114411; ENSMUSP00000110053; ENSMUSG00000054252.
ENSMUST00000171509; ENSMUSP00000131845; ENSMUSG00000054252.
GeneID14184.
KEGGmmu:14184.
UCSCuc012dut.2. mouse.

Organism-specific databases

CTD2261.
MGIMGI:95524. Fgfr3.

Phylogenomic databases

GeneTreeENSGT00670000097694.
KOK05094.
OMAVFTHDLL.
TreeFamTF316307.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24416:SF128. PTHR24416:SF128. 1 hit.
PfamPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000628. FGFR. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFGFR3. mouse.
NextBio285392.
SOURCESearch...

Entry information

Entry nameE9QNJ9_MOUSE
AccessionPrimary (citable) accession number: E9QNJ9
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)