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E9QNJ9

- E9QNJ9_MOUSE

UniProt

E9QNJ9 - E9QNJ9_MOUSE

Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei613 – 6131Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fibroblast growth factor-activated receptor activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. alveolar secondary septum development Source: MGI
    2. axonogenesis involved in innervation Source: MGI
    3. bone morphogenesis Source: MGI
    4. cartilage development Source: MGI
    5. cell differentiation Source: MGI
    6. central nervous system myelination Source: MGI
    7. cochlea development Source: MGI
    8. digestive tract morphogenesis Source: MGI
    9. epithelial cell fate commitment Source: MGI
    10. fibroblast growth factor receptor signaling pathway Source: MGI
    11. forebrain development Source: MGI
    12. inner ear development Source: MGI
    13. inner ear receptor cell differentiation Source: MGI
    14. lens fiber cell development Source: MGI
    15. lens morphogenesis in camera-type eye Source: MGI
    16. MAPK cascade Source: MGI
    17. morphogenesis of an epithelium Source: MGI
    18. negative regulation of astrocyte differentiation Source: MGI
    19. negative regulation of cell proliferation Source: MGI
    20. negative regulation of epithelial cell proliferation Source: MGI
    21. negative regulation of mitosis Source: MGI
    22. negative regulation of smoothened signaling pathway Source: MGI
    23. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    24. oligodendrocyte development Source: MGI
    25. positive regulation of canonical Wnt signaling pathway Source: MGI
    26. positive regulation of cell differentiation Source: MGI
    27. positive regulation of cell proliferation Source: MGI
    28. positive regulation of endothelial cell proliferation Source: MGI
    29. positive regulation of MAPK cascade Source: MGI
    30. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI
    31. positive regulation of neuron apoptotic process Source: MGI
    32. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    33. positive regulation of protein ubiquitination Source: MGI
    34. response to axon injury Source: MGI
    35. somatic stem cell maintenance Source: MGI
    36. substantia nigra development Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196532. t(4;14) translocations of FGFR3.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_213224. FGFR3b ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
    Gene namesi
    Name:Fgfr3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:95524. Fgfr3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosome Source: MGI
    4. perinuclear region of cytoplasm Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation, PhosphoproteinSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00670000097694.
    KOiK05094.
    OMAiVFTHDLL.
    TreeFamiTF316307.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR028176. FGF_rcpt_3.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
    PfamiPF07679. I-set. 2 hits.
    PF00047. ig. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000628. FGFR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QNJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG    50
    SGDTVELSCH PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE 100
    DAGVYSCQHR LTRRVLCHFS VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP 150
    ERMDKKLLAV PAANTVRFRC PAAGNPTPSI SWLKNGKEFR GEHRIGGIKL 200
    RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL ERSPHRPILQ 250
    AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYV 300
    TVLKSWISEN VEADARLRLA NVSERDGGEY LCRATNFIGV AEKAFWLRVH 350
    GPQAAEEELM ETDEAGSVYA GVLSYGVVFF LFILVVAAVI LCRLRSPPKK 400
    GLGSPTVHKV SRFPLKRQVS LESNSSMNSN TPLVRIARLS SGEGPVLANV 450
    SELELPADPK WELSRTRLTL GKPLGEGCFG QVVMAEAIGI DKDRTAKPVT 500
    VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQGGPLYVL 550
    VEYAAKGNLR EFLRARRPPG MDYSFDACRL PEEQLTCKDL VSCAYQVARG 600
    MEYLASQKCI HRDLAARNVL VTEDNVMKIA DFGLARDVHN LDYYKKTTNG 650
    RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLL WEIFTLGGSP YPGIPVEELF 700
    KLLKEGHRMD KPASCTHDLY MIMRECWHAV PSQRPTFKQL VEDLDRILTV 750
    TSTDEYLDLS VPFEQYSPGG QDTPSSSSSG DDSVFTHDLL PPGPPSNGGP 800
    RT 802
    Length:802
    Mass (Da):88,165
    Last modified:April 5, 2011 - v1
    Checksum:i6DADCB5A2F20731F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC162898 Genomic DNA. No translation available.
    RefSeqiNP_001156689.1. NM_001163217.2.
    XP_006503791.1. XM_006503728.1.
    UniGeneiMm.6904.

    Genome annotation databases

    EnsembliENSMUST00000114411; ENSMUSP00000110053; ENSMUSG00000054252.
    ENSMUST00000171509; ENSMUSP00000131845; ENSMUSG00000054252.
    GeneIDi14184.
    KEGGimmu:14184.
    UCSCiuc012dut.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC162898 Genomic DNA. No translation available.
    RefSeqi NP_001156689.1. NM_001163217.2.
    XP_006503791.1. XM_006503728.1.
    UniGenei Mm.6904.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114411 ; ENSMUSP00000110053 ; ENSMUSG00000054252 .
    ENSMUST00000171509 ; ENSMUSP00000131845 ; ENSMUSG00000054252 .
    GeneIDi 14184.
    KEGGi mmu:14184.
    UCSCi uc012dut.2. mouse.

    Organism-specific databases

    CTDi 2261.
    MGIi MGI:95524. Fgfr3.

    Phylogenomic databases

    GeneTreei ENSGT00670000097694.
    KOi K05094.
    OMAi VFTHDLL.
    TreeFami TF316307.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196532. t(4;14) translocations of FGFR3.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_213224. FGFR3b ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    ChiTaRSi FGFR3. mouse.
    NextBioi 285392.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR028176. FGF_rcpt_3.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24416:SF128. PTHR24416:SF128. 1 hit.
    Pfami PF07679. I-set. 2 hits.
    PF00047. ig. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000628. FGFR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QNJ9_MOUSE
    AccessioniPrimary (citable) accession number: E9QNJ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3