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E9QNJ9

- E9QNJ9_MOUSE

UniProt

E9QNJ9 - E9QNJ9_MOUSE

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Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei613 – 6131Proton acceptorUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fibroblast growth factor-activated receptor activity Source: MGI

GO - Biological processi

  1. alveolar secondary septum development Source: MGI
  2. axonogenesis involved in innervation Source: MGI
  3. bone morphogenesis Source: MGI
  4. cartilage development Source: MGI
  5. cell differentiation Source: MGI
  6. central nervous system myelination Source: MGI
  7. cochlea development Source: MGI
  8. digestive tract morphogenesis Source: MGI
  9. epithelial cell fate commitment Source: MGI
  10. fibroblast growth factor receptor signaling pathway Source: MGI
  11. forebrain development Source: MGI
  12. inner ear development Source: MGI
  13. inner ear receptor cell differentiation Source: MGI
  14. lens fiber cell development Source: MGI
  15. lens morphogenesis in camera-type eye Source: MGI
  16. MAPK cascade Source: MGI
  17. morphogenesis of an epithelium Source: MGI
  18. negative regulation of astrocyte differentiation Source: MGI
  19. negative regulation of cell proliferation Source: MGI
  20. negative regulation of epithelial cell proliferation Source: MGI
  21. negative regulation of mitosis Source: MGI
  22. negative regulation of smoothened signaling pathway Source: MGI
  23. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  24. oligodendrocyte development Source: MGI
  25. positive regulation of canonical Wnt signaling pathway Source: MGI
  26. positive regulation of cell differentiation Source: MGI
  27. positive regulation of cell proliferation Source: MGI
  28. positive regulation of endothelial cell proliferation Source: MGI
  29. positive regulation of MAPK cascade Source: MGI
  30. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI
  31. positive regulation of neuron apoptotic process Source: MGI
  32. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  33. positive regulation of protein ubiquitination Source: MGI
  34. response to axon injury Source: MGI
  35. somatic stem cell maintenance Source: MGI
  36. substantia nigra development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196532. t(4;14) translocations of FGFR3.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_230708. Phospholipase C-mediated cascade.
REACT_234357. FRS2-mediated cascade.
REACT_240139. PI3K Cascade.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:95524. Fgfr3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: MGI
  4. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923.
KOiK05094.
OMAiVFTHDLL.
TreeFamiTF316307.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QNJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG
60 70 80 90 100
SGDTVELSCH PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE
110 120 130 140 150
DAGVYSCQHR LTRRVLCHFS VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP
160 170 180 190 200
ERMDKKLLAV PAANTVRFRC PAAGNPTPSI SWLKNGKEFR GEHRIGGIKL
210 220 230 240 250
RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL ERSPHRPILQ
260 270 280 290 300
AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYV
310 320 330 340 350
TVLKSWISEN VEADARLRLA NVSERDGGEY LCRATNFIGV AEKAFWLRVH
360 370 380 390 400
GPQAAEEELM ETDEAGSVYA GVLSYGVVFF LFILVVAAVI LCRLRSPPKK
410 420 430 440 450
GLGSPTVHKV SRFPLKRQVS LESNSSMNSN TPLVRIARLS SGEGPVLANV
460 470 480 490 500
SELELPADPK WELSRTRLTL GKPLGEGCFG QVVMAEAIGI DKDRTAKPVT
510 520 530 540 550
VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQGGPLYVL
560 570 580 590 600
VEYAAKGNLR EFLRARRPPG MDYSFDACRL PEEQLTCKDL VSCAYQVARG
610 620 630 640 650
MEYLASQKCI HRDLAARNVL VTEDNVMKIA DFGLARDVHN LDYYKKTTNG
660 670 680 690 700
RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLL WEIFTLGGSP YPGIPVEELF
710 720 730 740 750
KLLKEGHRMD KPASCTHDLY MIMRECWHAV PSQRPTFKQL VEDLDRILTV
760 770 780 790 800
TSTDEYLDLS VPFEQYSPGG QDTPSSSSSG DDSVFTHDLL PPGPPSNGGP

RT
Length:802
Mass (Da):88,165
Last modified:April 5, 2011 - v1
Checksum:i6DADCB5A2F20731F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162898 Genomic DNA. No translation available.
RefSeqiNP_001156689.1. NM_001163217.2.
XP_006503791.1. XM_006503728.1.
UniGeneiMm.6904.

Genome annotation databases

EnsembliENSMUST00000114411; ENSMUSP00000110053; ENSMUSG00000054252.
ENSMUST00000171509; ENSMUSP00000131845; ENSMUSG00000054252.
GeneIDi14184.
KEGGimmu:14184.
UCSCiuc012dut.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162898 Genomic DNA. No translation available.
RefSeqi NP_001156689.1. NM_001163217.2.
XP_006503791.1. XM_006503728.1.
UniGenei Mm.6904.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114411 ; ENSMUSP00000110053 ; ENSMUSG00000054252 .
ENSMUST00000171509 ; ENSMUSP00000131845 ; ENSMUSG00000054252 .
GeneIDi 14184.
KEGGi mmu:14184.
UCSCi uc012dut.2. mouse.

Organism-specific databases

CTDi 2261.
MGIi MGI:95524. Fgfr3.

Phylogenomic databases

GeneTreei ENSGT00760000118923.
KOi K05094.
OMAi VFTHDLL.
TreeFami TF316307.

Enzyme and pathway databases

Reactomei REACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196532. t(4;14) translocations of FGFR3.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_230708. Phospholipase C-mediated cascade.
REACT_234357. FRS2-mediated cascade.
REACT_240139. PI3K Cascade.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

ChiTaRSi Fgfr3. mouse.
NextBioi 285392.
SOURCEi Search...

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
PANTHERi PTHR24416:SF128. PTHR24416:SF128. 1 hit.
Pfami PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000628. FGFR. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QNJ9_MOUSE
AccessioniPrimary (citable) accession number: E9QNJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3