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Protein
Submitted name:

Intersectin-2

Gene

Itsn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi67 – 78PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Submitted name:
Intersectin-2Imported
Gene namesi
Name:Itsn2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1338049 Itsn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9QNG1
PRIDEiE9QNG1

Expressioni

Gene expression databases

BgeeiENSMUSG00000020640
GenevisibleiE9QNG1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9QNG1, 18 interactors

Structurei

3D structure databases

ProteinModelPortaliE9QNG1
SMRiE9QNG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 110EHInterPro annotationAdd BLAST89
Domaini54 – 89EF-handInterPro annotationAdd BLAST36
Domaini245 – 334EHInterPro annotationAdd BLAST90
Domaini278 – 313EF-handInterPro annotationAdd BLAST36
Domaini718 – 779SH3InterPro annotationAdd BLAST62
Domaini852 – 910SH3InterPro annotationAdd BLAST59
Domaini942 – 1000SH3InterPro annotationAdd BLAST59
Domaini1014 – 1078SH3InterPro annotationAdd BLAST65
Domaini1088 – 1147SH3InterPro annotationAdd BLAST60
Domaini1170 – 1356DHInterPro annotationAdd BLAST187
Domaini1395 – 1505PHInterPro annotationAdd BLAST111
Domaini1531 – 1613C2InterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili369 – 461Sequence analysisAdd BLAST93
Coiled coili510 – 551Sequence analysisAdd BLAST42
Coiled coili586 – 641Sequence analysisAdd BLAST56
Coiled coili652 – 672Sequence analysisAdd BLAST21
Coiled coili679 – 715Sequence analysisAdd BLAST37
Coiled coili1343 – 1363Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1029 Eukaryota
KOG4305 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000118985
OMAiTIWTLAD
OrthoDBiEOG091G0TXR
TreeFamiTF324293

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11988 SH3_Intersectin2_1, 1 hit
cd11990 SH3_Intersectin2_2, 1 hit
cd11992 SH3_Intersectin2_3, 1 hit
cd11994 SH3_Intersectin2_4, 1 hit
cd11996 SH3_Intersectin2_5, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR027029 Intersectin-2
IPR035737 Intersectin-2_SH3_1
IPR035738 Intersectin-2_SH3_2
IPR035739 Intersectin-2_SH3_3
IPR035740 Intersectin-2_SH3_4
IPR035741 Intersectin-2_SH3_5
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR11216:SF29 PTHR11216:SF29, 4 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12763 EF-hand_4, 2 hits
PF16652 PH_13, 1 hit
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 2 hits
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00054 EFh, 2 hits
SM00027 EH, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 5 hits
SUPFAMiSSF47473 SSF47473, 2 hits
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 5 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50010 DH_2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS50031 EH, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 5 hits

Sequencei

Sequence statusi: Complete.

E9QNG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIHQP LPPVAPIATP LSSATSGTSI
160 170 180 190 200
PPLMMPAPLV PSVSTSSLPN GTASLIQPLS IPYSSSTLPH ASSYSLMMGG
210 220 230 240 250
FGGASIQKAQ SLIDLGSSSS TSSTASLSGN SPKTGTSEWA VPQPSRLKYR
260 270 280 290 300
QKFNSLDKGM SGYLSGFQAR NALLQSNLSQ TQLATIWTLA DIDGDGQLKA
310 320 330 340 350
EEFILAMHLT DMAKAGQPLP LTLPPELVPP SFRGGKQVDS VNGTLPSYQK
360 370 380 390 400
TQEEEPQKKL PVTFEDKRKA NYERGNMELE KRRQVLMEQQ QREAERKAQK
410 420 430 440 450
EKEEWERKQR ELQEQEWKKQ LELEKRLEKQ RELERQREEE RRKEIERREA
460 470 480 490 500
AKQELERQRR LEWERLRRQE LLSQKTREQE DIVRLSSRKK SLHLELEAVN
510 520 530 540 550
GKHQQISGRL QDVQIRKQTQ KTELEVLDKQ CDLEIMEIKQ LQQELKEYQN
560 570 580 590 600
KLIYLVPEKQ LLNERIKNMQ LSNTPDSGIS LLHKKSSEKE ELCQRLKEQL
610 620 630 640 650
DALEKETASK LSEMDSFNNQ LKELRESYNT QQLALEQLHK IKRDKLKEIE
660 670 680 690 700
RKRLEQIQKK KLEDEAARKA KQGKENLWRE SIRKEEEEKQ KRLQEEKSQD
710 720 730 740 750
KTQEEERKAE AKQSETASAL VNYRALYPFE ARNHDEMSFS SGDIIQVDEK
760 770 780 790 800
TVGEPGWLYG SFQGKFGWFP CNYVEKVLSS EKALSPKKAL LPPTVSLSAT
810 820 830 840 850
STSSQPPASV TDYHNVSFSN LTVNTTWQQK SAFTRTVSPG SVSPIHGQGQ
860 870 880 890 900
AVENLKAQAL CSWTAKKENH LNFSKHDVIT VLEQQENWWF GEVHGGRGWF
910 920 930 940 950
PKSYVKLIPG NEVQRGEPEA LYAAVTKKPT STAYPVTSTA YPVGEDYIAL
960 970 980 990 1000
YSYSSVEPGD LTFTEGEEIL VTQKDGEWWT GSIGERTGIF PSNYVRPKDQ
1010 1020 1030 1040 1050
ENFGNASKSG ASNKKPEIAQ VTSAYAASGT EQLSLAPGQL ILILKKNTSG
1060 1070 1080 1090 1100
WWQGELQARG KKRQKGWFPA SHVKLLGPSS ERTMPTFHAV CQVIAMYDYM
1110 1120 1130 1140 1150
ANNEDELNFS KGQLINVMNK DDPDWWQGET NGLTGLFPSN YVKMTTDSDP
1160 1170 1180 1190 1200
SQQWCADLQA LDTMQPTERK RQGYIHELIQ TEERYMDDLQ LVIEVFQKRM
1210 1220 1230 1240 1250
AESGFLTEAD MALIFVNWKE LIMSNTKLLR ALRVRKKTGG EKMPVQMIGD
1260 1270 1280 1290 1300
ILAAELSHMQ AYIRFCSCQL NGATLLQQKT DEDTDFKEFL KKLASDPRCK
1310 1320 1330 1340 1350
GMPLSSFLLK PMQRITRYPL LIRSILENTP QSHVDHSSLK LALERAEELC
1360 1370 1380 1390 1400
SQVNEGVREK ENSDRLEWIQ AHVQCEGLAE QLIFNSLTNC LGPRKLLHSG
1410 1420 1430 1440 1450
KLYKTKSNKE LHAFLFNDFL LLTYLVRQFA AASGHEKLFN SKSSAQFRMY
1460 1470 1480 1490 1500
KTPIFLNEVL VKLPTDPSSD EPVFHISHID RVYTLRTDNI NERTAWVQKI
1510 1520 1530 1540 1550
KGASEQYIDT EKKKREKAYQ ARSQKTSGIG RLMVHVIEAT ELKACKPNGK
1560 1570 1580 1590 1600
SNPYCEVSMG SQSYTTRTLQ DTLNPKWNFN CQFFIKDLYQ DVLCLTMFDR
1610 1620 1630 1640 1650
DQFSPDDFLG RTEVPVAKIR TEQESKGPTT RRLLLHEVPT GEVWVRFDLQ

LFEQKTLL
Length:1,658
Mass (Da):188,781
Last modified:April 5, 2011 - v1
Checksum:i8FA0B59B19319A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158232 Genomic DNA No translation available.
AC241534 Genomic DNA No translation available.
CT025683 Genomic DNA No translation available.
RefSeqiNP_035495.2, NM_011365.4
UniGeneiMm.341204

Genome annotation databases

EnsembliENSMUST00000062580; ENSMUSP00000052758; ENSMUSG00000020640
ENSMUST00000219007; ENSMUSP00000151900; ENSMUSG00000020640
GeneIDi20403
UCSCiuc007mxx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QNG1_MOUSE
AccessioniPrimary (citable) accession number: E9QNG1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health