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Protein
Submitted name:

Intersectin-2

Gene

Itsn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi67 – 78PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Intersectin-2Imported
Gene namesi
Name:Itsn2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1338049. Itsn2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE9QNG1.
PRIDEiE9QNG1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020640.
GenevisibleiE9QNG1. MM.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9QNG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 110EHInterPro annotationAdd BLAST89
Domaini54 – 89EF-handInterPro annotationAdd BLAST36
Domaini245 – 334EHInterPro annotationAdd BLAST90
Domaini278 – 313EF-handInterPro annotationAdd BLAST36
Domaini718 – 779SH3InterPro annotationAdd BLAST62
Domaini852 – 910SH3InterPro annotationAdd BLAST59
Domaini942 – 1000SH3InterPro annotationAdd BLAST59
Domaini1014 – 1078SH3InterPro annotationAdd BLAST65
Domaini1088 – 1147SH3InterPro annotationAdd BLAST60
Domaini1170 – 1356DHInterPro annotationAdd BLAST187
Domaini1395 – 1505PHInterPro annotationAdd BLAST111
Domaini1531 – 1613C2InterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili369 – 461Sequence analysisAdd BLAST93
Coiled coili510 – 551Sequence analysisAdd BLAST42
Coiled coili586 – 641Sequence analysisAdd BLAST56
Coiled coili679 – 715Sequence analysisAdd BLAST37

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
OMAiTIWTLAD.
OrthoDBiEOG091G0TXR.
TreeFamiTF324293.

Family and domain databases

CDDicd00160. RhoGEF. 1 hit.
cd11988. SH3_Intersectin2_1. 1 hit.
cd11990. SH3_Intersectin2_2. 1 hit.
cd11992. SH3_Intersectin2_3. 1 hit.
cd11994. SH3_Intersectin2_4. 1 hit.
cd11996. SH3_Intersectin2_5. 1 hit.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR035737. Intersectin-2_SH3_1.
IPR035738. Intersectin-2_SH3_2.
IPR035739. Intersectin-2_SH3_3.
IPR035740. Intersectin-2_SH3_4.
IPR035741. Intersectin-2_SH3_5.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 4 hits.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.

Sequencei

Sequence statusi: Complete.

E9QNG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIHQP LPPVAPIATP LSSATSGTSI
160 170 180 190 200
PPLMMPAPLV PSVSTSSLPN GTASLIQPLS IPYSSSTLPH ASSYSLMMGG
210 220 230 240 250
FGGASIQKAQ SLIDLGSSSS TSSTASLSGN SPKTGTSEWA VPQPSRLKYR
260 270 280 290 300
QKFNSLDKGM SGYLSGFQAR NALLQSNLSQ TQLATIWTLA DIDGDGQLKA
310 320 330 340 350
EEFILAMHLT DMAKAGQPLP LTLPPELVPP SFRGGKQVDS VNGTLPSYQK
360 370 380 390 400
TQEEEPQKKL PVTFEDKRKA NYERGNMELE KRRQVLMEQQ QREAERKAQK
410 420 430 440 450
EKEEWERKQR ELQEQEWKKQ LELEKRLEKQ RELERQREEE RRKEIERREA
460 470 480 490 500
AKQELERQRR LEWERLRRQE LLSQKTREQE DIVRLSSRKK SLHLELEAVN
510 520 530 540 550
GKHQQISGRL QDVQIRKQTQ KTELEVLDKQ CDLEIMEIKQ LQQELKEYQN
560 570 580 590 600
KLIYLVPEKQ LLNERIKNMQ LSNTPDSGIS LLHKKSSEKE ELCQRLKEQL
610 620 630 640 650
DALEKETASK LSEMDSFNNQ LKELRESYNT QQLALEQLHK IKRDKLKEIE
660 670 680 690 700
RKRLEQIQKK KLEDEAARKA KQGKENLWRE SIRKEEEEKQ KRLQEEKSQD
710 720 730 740 750
KTQEEERKAE AKQSETASAL VNYRALYPFE ARNHDEMSFS SGDIIQVDEK
760 770 780 790 800
TVGEPGWLYG SFQGKFGWFP CNYVEKVLSS EKALSPKKAL LPPTVSLSAT
810 820 830 840 850
STSSQPPASV TDYHNVSFSN LTVNTTWQQK SAFTRTVSPG SVSPIHGQGQ
860 870 880 890 900
AVENLKAQAL CSWTAKKENH LNFSKHDVIT VLEQQENWWF GEVHGGRGWF
910 920 930 940 950
PKSYVKLIPG NEVQRGEPEA LYAAVTKKPT STAYPVTSTA YPVGEDYIAL
960 970 980 990 1000
YSYSSVEPGD LTFTEGEEIL VTQKDGEWWT GSIGERTGIF PSNYVRPKDQ
1010 1020 1030 1040 1050
ENFGNASKSG ASNKKPEIAQ VTSAYAASGT EQLSLAPGQL ILILKKNTSG
1060 1070 1080 1090 1100
WWQGELQARG KKRQKGWFPA SHVKLLGPSS ERTMPTFHAV CQVIAMYDYM
1110 1120 1130 1140 1150
ANNEDELNFS KGQLINVMNK DDPDWWQGET NGLTGLFPSN YVKMTTDSDP
1160 1170 1180 1190 1200
SQQWCADLQA LDTMQPTERK RQGYIHELIQ TEERYMDDLQ LVIEVFQKRM
1210 1220 1230 1240 1250
AESGFLTEAD MALIFVNWKE LIMSNTKLLR ALRVRKKTGG EKMPVQMIGD
1260 1270 1280 1290 1300
ILAAELSHMQ AYIRFCSCQL NGATLLQQKT DEDTDFKEFL KKLASDPRCK
1310 1320 1330 1340 1350
GMPLSSFLLK PMQRITRYPL LIRSILENTP QSHVDHSSLK LALERAEELC
1360 1370 1380 1390 1400
SQVNEGVREK ENSDRLEWIQ AHVQCEGLAE QLIFNSLTNC LGPRKLLHSG
1410 1420 1430 1440 1450
KLYKTKSNKE LHAFLFNDFL LLTYLVRQFA AASGHEKLFN SKSSAQFRMY
1460 1470 1480 1490 1500
KTPIFLNEVL VKLPTDPSSD EPVFHISHID RVYTLRTDNI NERTAWVQKI
1510 1520 1530 1540 1550
KGASEQYIDT EKKKREKAYQ ARSQKTSGIG RLMVHVIEAT ELKACKPNGK
1560 1570 1580 1590 1600
SNPYCEVSMG SQSYTTRTLQ DTLNPKWNFN CQFFIKDLYQ DVLCLTMFDR
1610 1620 1630 1640 1650
DQFSPDDFLG RTEVPVAKIR TEQESKGPTT RRLLLHEVPT GEVWVRFDLQ

LFEQKTLL
Length:1,658
Mass (Da):188,781
Last modified:April 5, 2011 - v1
Checksum:i8FA0B59B19319A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158232 Genomic DNA. No translation available.
AC241534 Genomic DNA. No translation available.
CT025683 Genomic DNA. No translation available.
RefSeqiNP_035495.2. NM_011365.4.
UniGeneiMm.341204.

Genome annotation databases

EnsembliENSMUST00000062580; ENSMUSP00000052758; ENSMUSG00000020640.
ENSMUST00000219007; ENSMUSP00000151900; ENSMUSG00000020640.
GeneIDi20403.
UCSCiuc007mxx.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiE9QNG1_MOUSE
AccessioniPrimary (citable) accession number: E9QNG1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported