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Protein
Submitted name:

Intersectin-2

Gene

Itsn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Intersectin-2Imported
Gene namesi
Name:Itsn2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1338049. Itsn2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9QNG1.
MaxQBiE9QNG1.
PaxDbiE9QNG1.

Expressioni

Gene expression databases

BgeeiE9QNG1.
GenevisibleiE9QNG1. MM.

Interactioni

Protein-protein interaction databases

IntActiE9QNG1. 18 interactions.
STRINGi10090.ENSMUSP00000052758.

Structurei

3D structure databases

ProteinModelPortaliE9QNG1.
SMRiE9QNG1. Positions 2-108, 237-333, 717-804, 855-909, 945-999, 1010-1512, 1529-1652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11089EHInterPro annotationAdd
BLAST
Domaini54 – 8936EF-handInterPro annotationAdd
BLAST
Domaini245 – 33490EHInterPro annotationAdd
BLAST
Domaini278 – 31336EF-handInterPro annotationAdd
BLAST
Domaini718 – 77962SH3InterPro annotationAdd
BLAST
Domaini852 – 91059SH3InterPro annotationAdd
BLAST
Domaini942 – 100059SH3InterPro annotationAdd
BLAST
Domaini1014 – 107865SH3InterPro annotationAdd
BLAST
Domaini1088 – 114760SH3InterPro annotationAdd
BLAST
Domaini1170 – 1356187DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini1395 – 1505111PHInterPro annotationAdd
BLAST
Domaini1531 – 161383C2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili369 – 46193Sequence analysisAdd
BLAST
Coiled coili510 – 55142Sequence analysisAdd
BLAST
Coiled coili586 – 64156Sequence analysisAdd
BLAST
Coiled coili679 – 71537Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 5 SH3 domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
OMAiFRGGKQI.
OrthoDBiEOG7WMCJ3.
TreeFamiTF324293.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QNG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIHQP LPPVAPIATP LSSATSGTSI
160 170 180 190 200
PPLMMPAPLV PSVSTSSLPN GTASLIQPLS IPYSSSTLPH ASSYSLMMGG
210 220 230 240 250
FGGASIQKAQ SLIDLGSSSS TSSTASLSGN SPKTGTSEWA VPQPSRLKYR
260 270 280 290 300
QKFNSLDKGM SGYLSGFQAR NALLQSNLSQ TQLATIWTLA DIDGDGQLKA
310 320 330 340 350
EEFILAMHLT DMAKAGQPLP LTLPPELVPP SFRGGKQVDS VNGTLPSYQK
360 370 380 390 400
TQEEEPQKKL PVTFEDKRKA NYERGNMELE KRRQVLMEQQ QREAERKAQK
410 420 430 440 450
EKEEWERKQR ELQEQEWKKQ LELEKRLEKQ RELERQREEE RRKEIERREA
460 470 480 490 500
AKQELERQRR LEWERLRRQE LLSQKTREQE DIVRLSSRKK SLHLELEAVN
510 520 530 540 550
GKHQQISGRL QDVQIRKQTQ KTELEVLDKQ CDLEIMEIKQ LQQELKEYQN
560 570 580 590 600
KLIYLVPEKQ LLNERIKNMQ LSNTPDSGIS LLHKKSSEKE ELCQRLKEQL
610 620 630 640 650
DALEKETASK LSEMDSFNNQ LKELRESYNT QQLALEQLHK IKRDKLKEIE
660 670 680 690 700
RKRLEQIQKK KLEDEAARKA KQGKENLWRE SIRKEEEEKQ KRLQEEKSQD
710 720 730 740 750
KTQEEERKAE AKQSETASAL VNYRALYPFE ARNHDEMSFS SGDIIQVDEK
760 770 780 790 800
TVGEPGWLYG SFQGKFGWFP CNYVEKVLSS EKALSPKKAL LPPTVSLSAT
810 820 830 840 850
STSSQPPASV TDYHNVSFSN LTVNTTWQQK SAFTRTVSPG SVSPIHGQGQ
860 870 880 890 900
AVENLKAQAL CSWTAKKENH LNFSKHDVIT VLEQQENWWF GEVHGGRGWF
910 920 930 940 950
PKSYVKLIPG NEVQRGEPEA LYAAVTKKPT STAYPVTSTA YPVGEDYIAL
960 970 980 990 1000
YSYSSVEPGD LTFTEGEEIL VTQKDGEWWT GSIGERTGIF PSNYVRPKDQ
1010 1020 1030 1040 1050
ENFGNASKSG ASNKKPEIAQ VTSAYAASGT EQLSLAPGQL ILILKKNTSG
1060 1070 1080 1090 1100
WWQGELQARG KKRQKGWFPA SHVKLLGPSS ERTMPTFHAV CQVIAMYDYM
1110 1120 1130 1140 1150
ANNEDELNFS KGQLINVMNK DDPDWWQGET NGLTGLFPSN YVKMTTDSDP
1160 1170 1180 1190 1200
SQQWCADLQA LDTMQPTERK RQGYIHELIQ TEERYMDDLQ LVIEVFQKRM
1210 1220 1230 1240 1250
AESGFLTEAD MALIFVNWKE LIMSNTKLLR ALRVRKKTGG EKMPVQMIGD
1260 1270 1280 1290 1300
ILAAELSHMQ AYIRFCSCQL NGATLLQQKT DEDTDFKEFL KKLASDPRCK
1310 1320 1330 1340 1350
GMPLSSFLLK PMQRITRYPL LIRSILENTP QSHVDHSSLK LALERAEELC
1360 1370 1380 1390 1400
SQVNEGVREK ENSDRLEWIQ AHVQCEGLAE QLIFNSLTNC LGPRKLLHSG
1410 1420 1430 1440 1450
KLYKTKSNKE LHAFLFNDFL LLTYLVRQFA AASGHEKLFN SKSSAQFRMY
1460 1470 1480 1490 1500
KTPIFLNEVL VKLPTDPSSD EPVFHISHID RVYTLRTDNI NERTAWVQKI
1510 1520 1530 1540 1550
KGASEQYIDT EKKKREKAYQ ARSQKTSGIG RLMVHVIEAT ELKACKPNGK
1560 1570 1580 1590 1600
SNPYCEVSMG SQSYTTRTLQ DTLNPKWNFN CQFFIKDLYQ DVLCLTMFDR
1610 1620 1630 1640 1650
DQFSPDDFLG RTEVPVAKIR TEQESKGPTT RRLLLHEVPT GEVWVRFDLQ

LFEQKTLL
Length:1,658
Mass (Da):188,781
Last modified:April 5, 2011 - v1
Checksum:i8FA0B59B19319A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158232 Genomic DNA. No translation available.
AC241534 Genomic DNA. No translation available.
CT025683 Genomic DNA. No translation available.
RefSeqiNP_035495.2. NM_011365.4.
UniGeneiMm.341204.

Genome annotation databases

EnsembliENSMUST00000062580; ENSMUSP00000052758; ENSMUSG00000020640.
GeneIDi20403.
UCSCiuc007mxx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158232 Genomic DNA. No translation available.
AC241534 Genomic DNA. No translation available.
CT025683 Genomic DNA. No translation available.
RefSeqiNP_035495.2. NM_011365.4.
UniGeneiMm.341204.

3D structure databases

ProteinModelPortaliE9QNG1.
SMRiE9QNG1. Positions 2-108, 237-333, 717-804, 855-909, 945-999, 1010-1512, 1529-1652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9QNG1. 18 interactions.
STRINGi10090.ENSMUSP00000052758.

Proteomic databases

EPDiE9QNG1.
MaxQBiE9QNG1.
PaxDbiE9QNG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062580; ENSMUSP00000052758; ENSMUSG00000020640.
GeneIDi20403.
UCSCiuc007mxx.1. mouse.

Organism-specific databases

CTDi50618.
MGIiMGI:1338049. Itsn2.

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
OMAiFRGGKQI.
OrthoDBiEOG7WMCJ3.
TreeFamiTF324293.

Miscellaneous databases

ChiTaRSiItsn2. mouse.
NextBioi298368.
SOURCEiSearch...

Gene expression databases

BgeeiE9QNG1.
GenevisibleiE9QNG1. MM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QNG1_MOUSE
AccessioniPrimary (citable) accession number: E9QNG1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.