E9QNB8 (E9QNB8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
N-lysine methyltransferase SETD8 Ensembl ENSMUSP00000052953

Gene names

Name:

Setd8 Ensembl ENSMUSP00000052953 MGI 1915206

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000052953

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 SET domain. SAAS SAAS001214 RuleBase RU004538
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000052953

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara peptidyl-lysine monomethylation Inferred from electronic annotation. Source: Compara regulation of DNA damage response, signal transduction by p53 class mediator Inferred from electronic annotation. Source: Compara
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: Compara transcription corepressor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9QNB8 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 86B0C541ABDA5796	FASTA	350	38,931
	10 20 30 40 50 60 MARGRKMCKP RAVEAAAAAV AATAPGPEMV EQRGPGRPRS DGENVFAGQS KIYAYMSPNK 70 80 90 100 110 120 CSAMRSPLQE ENSVAHHEVK CPGKPLAGIY RKREEKRNTG NVIRSAVKSD EQKSKDTRRG 130 140 150 160 170 180 PLAPFPNQKS EAAEPPKTPP PSCDSTNVAV AKQALKKSLK GKQAPRKKSQ GKTQQNRKLT 190 200 210 220 230 240 DFYPVRRSSR KSKAELQSEE RKKIDELIES GKEEGMKIDL IDGKGRGVIA TKQFSRGDFV 250 260 270 280 290 300 VEYHGDLIEI TDAKKREALY AQDPSTGCYM YYFQYLSKTY CVDATQETNR LGRLINHSKC 310 320 330 340 350 GNCQTKLHDI DGVPHLILIA SRDIAAGEEL LYDYGDRSKA SIEAYPWLKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000052953.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000052953.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC127339 Genomic DNA. No translation available.
IPI	IPI00409777.
RefSeq	NP_084517.2. NM_030241.2.
UniGene	Mm.137966.
3D structure databases
ProteinModelPortal	E9QNB8.
SMR	E9QNB8. Positions 190-350.
ModBase	Search...
Proteomic databases
PRIDE	E9QNB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000059580; ENSMUSP00000052953; ENSMUSG00000049327.
GeneID	67956.
KEGG	mmu:67956.
UCSC	uc008zpu.1. mouse.
Organism-specific databases
CTD	387893.
MGI	MGI:1915206. Setd8.
Phylogenomic databases
GeneTree	ENSGT00410000025501.
KO	K11428.
OMA	FSRGEFV.
Gene expression databases
ArrayExpress	E9QNB8.
Bgee	E9QNB8.
Family and domain databases
InterPro	IPR016858. Hist_H4-K20_MeTrfase. IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
PIRSF	PIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS51571. SAM_MT43_PR_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SETD8. mouse.
NextBio	326066.
SOURCE	Search...

Entry information

Entry name

E9QNB8_MOUSE

Accession

Primary (citable) accession number: E9QNB8

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 29, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)