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E9QNB8

- E9QNB8_MOUSE

UniProt

E9QNB8 - E9QNB8_MOUSE

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Protein
Submitted name:

N-lysine methyltransferase SETD8

Gene

Setd8

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: Ensembl
  2. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. peptidyl-lysine monomethylation Source: Ensembl
  3. regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196580. Condensation of Prophase Chromosomes.

Names & Taxonomyi

Protein namesi
Submitted name:
N-lysine methyltransferase SETD8Imported
Gene namesi
Name:Setd8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1915206. Setd8.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9QNB8.

Expressioni

Gene expression databases

BgeeiE9QNB8.
ExpressionAtlasiE9QNB8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9QNB8.
SMRiE9QNB8. Positions 190-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00410000025501.
KOiK11428.
OMAiCSGMRSP.
OrthoDBiEOG70KGRN.
TreeFamiTF335181.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QNB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARGRKMCKP RAVEAAAAAV AATAPGPEMV EQRGPGRPRS DGENVFAGQS
60 70 80 90 100
KIYAYMSPNK CSAMRSPLQE ENSVAHHEVK CPGKPLAGIY RKREEKRNTG
110 120 130 140 150
NVIRSAVKSD EQKSKDTRRG PLAPFPNQKS EAAEPPKTPP PSCDSTNVAV
160 170 180 190 200
AKQALKKSLK GKQAPRKKSQ GKTQQNRKLT DFYPVRRSSR KSKAELQSEE
210 220 230 240 250
RKKIDELIES GKEEGMKIDL IDGKGRGVIA TKQFSRGDFV VEYHGDLIEI
260 270 280 290 300
TDAKKREALY AQDPSTGCYM YYFQYLSKTY CVDATQETNR LGRLINHSKC
310 320 330 340 350
GNCQTKLHDI DGVPHLILIA SRDIAAGEEL LYDYGDRSKA SIEAYPWLKH
Length:350
Mass (Da):38,931
Last modified:April 5, 2011 - v1
Checksum:i86B0C541ABDA5796
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC127339 Genomic DNA. No translation available.
RefSeqiNP_084517.2. NM_030241.2.
UniGeneiMm.137966.

Genome annotation databases

EnsembliENSMUST00000059580; ENSMUSP00000052953; ENSMUSG00000049327.
GeneIDi67956.
KEGGimmu:67956.
UCSCiuc008zpu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC127339 Genomic DNA. No translation available.
RefSeqi NP_084517.2. NM_030241.2.
UniGenei Mm.137966.

3D structure databases

ProteinModelPortali E9QNB8.
SMRi E9QNB8. Positions 190-350.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9QNB8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059580 ; ENSMUSP00000052953 ; ENSMUSG00000049327 .
GeneIDi 67956.
KEGGi mmu:67956.
UCSCi uc008zpu.1. mouse.

Organism-specific databases

CTDi 387893.
MGIi MGI:1915206. Setd8.

Phylogenomic databases

GeneTreei ENSGT00410000025501.
KOi K11428.
OMAi CSGMRSP.
OrthoDBi EOG70KGRN.
TreeFami TF335181.

Enzyme and pathway databases

Reactomei REACT_196580. Condensation of Prophase Chromosomes.

Miscellaneous databases

ChiTaRSi SETD8. mouse.
NextBioi 326066.
SOURCEi Search...

Gene expression databases

Bgeei E9QNB8.
ExpressionAtlasi E9QNB8. baseline and differential.

Family and domain databases

InterProi IPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QNB8_MOUSE
AccessioniPrimary (citable) accession number: E9QNB8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3