Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

N-lysine methyltransferase SETD8

Gene

Setd8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: MGI
  2. p53 binding Source: MGI
  3. protein-lysine N-methyltransferase activity Source: MGI
  4. transcription corepressor activity Source: MGI

GO - Biological processi

  1. histone lysine methylation Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  4. peptidyl-lysine monomethylation Source: MGI
  5. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196580. Condensation of Prophase Chromosomes.

Names & Taxonomyi

Protein namesi
Submitted name:
N-lysine methyltransferase SETD8Imported
Gene namesi
Name:Setd8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1915206. Setd8.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9QNB8.

Expressioni

Gene expression databases

BgeeiE9QNB8.
ExpressionAtlasiE9QNB8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9QNB8.
SMRiE9QNB8. Positions 190-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00410000025501.
KOiK11428.
OMAiCSGMRSP.
OrthoDBiEOG70KGRN.
TreeFamiTF335181.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QNB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGRKMCKP RAVEAAAAAV AATAPGPEMV EQRGPGRPRS DGENVFAGQS
60 70 80 90 100
KIYAYMSPNK CSAMRSPLQE ENSVAHHEVK CPGKPLAGIY RKREEKRNTG
110 120 130 140 150
NVIRSAVKSD EQKSKDTRRG PLAPFPNQKS EAAEPPKTPP PSCDSTNVAV
160 170 180 190 200
AKQALKKSLK GKQAPRKKSQ GKTQQNRKLT DFYPVRRSSR KSKAELQSEE
210 220 230 240 250
RKKIDELIES GKEEGMKIDL IDGKGRGVIA TKQFSRGDFV VEYHGDLIEI
260 270 280 290 300
TDAKKREALY AQDPSTGCYM YYFQYLSKTY CVDATQETNR LGRLINHSKC
310 320 330 340 350
GNCQTKLHDI DGVPHLILIA SRDIAAGEEL LYDYGDRSKA SIEAYPWLKH
Length:350
Mass (Da):38,931
Last modified:April 5, 2011 - v1
Checksum:i86B0C541ABDA5796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127339 Genomic DNA. No translation available.
RefSeqiNP_084517.2. NM_030241.2.
UniGeneiMm.137966.

Genome annotation databases

EnsembliENSMUST00000059580; ENSMUSP00000052953; ENSMUSG00000049327.
GeneIDi67956.
KEGGimmu:67956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127339 Genomic DNA. No translation available.
RefSeqiNP_084517.2. NM_030241.2.
UniGeneiMm.137966.

3D structure databases

ProteinModelPortaliE9QNB8.
SMRiE9QNB8. Positions 190-350.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9QNB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059580; ENSMUSP00000052953; ENSMUSG00000049327.
GeneIDi67956.
KEGGimmu:67956.

Organism-specific databases

CTDi387893.
MGIiMGI:1915206. Setd8.

Phylogenomic databases

GeneTreeiENSGT00410000025501.
KOiK11428.
OMAiCSGMRSP.
OrthoDBiEOG70KGRN.
TreeFamiTF335181.

Enzyme and pathway databases

ReactomeiREACT_196580. Condensation of Prophase Chromosomes.

Miscellaneous databases

ChiTaRSiSetd8. mouse.
NextBioi326066.
SOURCEiSearch...

Gene expression databases

BgeeiE9QNB8.
ExpressionAtlasiE9QNB8. baseline and differential.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QNB8_MOUSE
AccessioniPrimary (citable) accession number: E9QNB8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.