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E9QNB8

- E9QNB8_MOUSE

UniProt

E9QNB8 - E9QNB8_MOUSE

Protein
Submitted name:

N-lysine methyltransferase SETD8

Gene

Setd8

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: Ensembl
    2. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. peptidyl-lysine monomethylation Source: Ensembl
    3. regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196580. Condensation of Prophase Chromosomes.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    N-lysine methyltransferase SETD8Imported
    Gene namesi
    Name:Setd8Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1915206. Setd8.

    PTM / Processingi

    Proteomic databases

    PRIDEiE9QNB8.

    Expressioni

    Gene expression databases

    ArrayExpressiE9QNB8.
    BgeeiE9QNB8.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QNB8.
    SMRiE9QNB8. Positions 190-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00410000025501.
    KOiK11428.
    OMAiCSGMRSP.
    OrthoDBiEOG70KGRN.
    TreeFamiTF335181.

    Family and domain databases

    InterProiIPR016858. Hist_H4-K20_MeTrfase.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QNB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGRKMCKP RAVEAAAAAV AATAPGPEMV EQRGPGRPRS DGENVFAGQS    50
    KIYAYMSPNK CSAMRSPLQE ENSVAHHEVK CPGKPLAGIY RKREEKRNTG 100
    NVIRSAVKSD EQKSKDTRRG PLAPFPNQKS EAAEPPKTPP PSCDSTNVAV 150
    AKQALKKSLK GKQAPRKKSQ GKTQQNRKLT DFYPVRRSSR KSKAELQSEE 200
    RKKIDELIES GKEEGMKIDL IDGKGRGVIA TKQFSRGDFV VEYHGDLIEI 250
    TDAKKREALY AQDPSTGCYM YYFQYLSKTY CVDATQETNR LGRLINHSKC 300
    GNCQTKLHDI DGVPHLILIA SRDIAAGEEL LYDYGDRSKA SIEAYPWLKH 350
    Length:350
    Mass (Da):38,931
    Last modified:April 5, 2011 - v1
    Checksum:i86B0C541ABDA5796
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127339 Genomic DNA. No translation available.
    RefSeqiNP_084517.2. NM_030241.2.
    UniGeneiMm.137966.

    Genome annotation databases

    EnsembliENSMUST00000059580; ENSMUSP00000052953; ENSMUSG00000049327.
    GeneIDi67956.
    KEGGimmu:67956.
    UCSCiuc008zpu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127339 Genomic DNA. No translation available.
    RefSeqi NP_084517.2. NM_030241.2.
    UniGenei Mm.137966.

    3D structure databases

    ProteinModelPortali E9QNB8.
    SMRi E9QNB8. Positions 190-350.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9QNB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059580 ; ENSMUSP00000052953 ; ENSMUSG00000049327 .
    GeneIDi 67956.
    KEGGi mmu:67956.
    UCSCi uc008zpu.1. mouse.

    Organism-specific databases

    CTDi 387893.
    MGIi MGI:1915206. Setd8.

    Phylogenomic databases

    GeneTreei ENSGT00410000025501.
    KOi K11428.
    OMAi CSGMRSP.
    OrthoDBi EOG70KGRN.
    TreeFami TF335181.

    Enzyme and pathway databases

    Reactomei REACT_196580. Condensation of Prophase Chromosomes.

    Miscellaneous databases

    ChiTaRSi SETD8. mouse.
    NextBioi 326066.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9QNB8.
    Bgeei E9QNB8.

    Family and domain databases

    InterProi IPR016858. Hist_H4-K20_MeTrfase.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51571. SAM_MT43_PR_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QNB8_MOUSE
    AccessioniPrimary (citable) accession number: E9QNB8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3