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Protein

Mitogen-activated protein kinase

Gene

Mapk10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-450341 Activation of the AP-1 family of transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:Mapk10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1346863 Mapk10

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiE9QN59
PeptideAtlasiE9QN59
PRIDEiE9QN59

Expressioni

Gene expression databases

BgeeiENSMUSG00000046709
ExpressionAtlasiE9QN59 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9QN59
SMRiE9QN59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 389Protein kinaseInterPro annotationAdd BLAST296

Phylogenomic databases

eggNOGiKOG0665 Eukaryota
ENOG410XSHI LUCA
GeneTreeiENSGT00550000074271
OMAiMSRHFLY
OrthoDBiEOG091G09G2

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008351 MAPK_JNK
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01772 JNKMAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

E9QN59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDTGVSGAP MKEMAQVMRI AEVTEDGRVF MSLHFLYYCS EPTLDVKIAF
60 70 80 90 100
CQGFDKHVDV SSIAKHYNMS KSKVDNQFYS VEVGDSTFTV LKRYQNLKPI
110 120 130 140 150
GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH
160 170 180 190 200
KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL
210 220 230 240 250
YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM
260 270 280 290 300
TPYVVTRYYR APEVILGMGY KENVDIWSVG CIMGEMVRHK ILFPGRDYID
310 320 330 340 350
QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN RPKYAGLTFP KLFPDSLFPA
360 370 380 390 400
DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN VWYDPAEVEA
410 420 430 440 450
PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA
460 470 480 490
VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR
Length:494
Mass (Da):55,714
Last modified:April 5, 2011 - v1
Checksum:i0B07B6C2E5630B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123664 Genomic DNA No translation available.
AC125252 Genomic DNA No translation available.
AC137121 Genomic DNA No translation available.
AC160244 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000112848; ENSMUSP00000108469; ENSMUSG00000046709

Similar proteinsi

Entry informationi

Entry nameiE9QN59_MOUSE
AccessioniPrimary (citable) accession number: E9QN59
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health