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Protein

Mitogen-activated protein kinase

Gene

Mapk10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_288310. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_305463. Oxidative Stress Induced Senescence.
REACT_314186. FCERI mediated MAPK activation.
REACT_320943. Activation of the AP-1 family of transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:Mapk10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1346863. Mapk10.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. mitochondrion Source: MGI
  3. neuronal postsynaptic density Source: MGI
  4. plasma membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9QN59.
PRIDEiE9QN59.

Expressioni

Gene expression databases

BgeeiE9QN59.
ExpressionAtlasiE9QN59. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9QN59.
SMRiE9QN59. Positions 41-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074271.
OMAiDCLFPAD.
OrthoDBiEOG7PCJGV.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QN59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDTGVSGAP MKEMAQVMRI AEVTEDGRVF MSLHFLYYCS EPTLDVKIAF
60 70 80 90 100
CQGFDKHVDV SSIAKHYNMS KSKVDNQFYS VEVGDSTFTV LKRYQNLKPI
110 120 130 140 150
GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH
160 170 180 190 200
KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL
210 220 230 240 250
YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM
260 270 280 290 300
TPYVVTRYYR APEVILGMGY KENVDIWSVG CIMGEMVRHK ILFPGRDYID
310 320 330 340 350
QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN RPKYAGLTFP KLFPDSLFPA
360 370 380 390 400
DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN VWYDPAEVEA
410 420 430 440 450
PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA
460 470 480 490
VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR
Length:494
Mass (Da):55,714
Last modified:April 4, 2011 - v1
Checksum:i0B07B6C2E5630B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123664 Genomic DNA. No translation available.
AC125252 Genomic DNA. No translation available.
AC137121 Genomic DNA. No translation available.
AC160244 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000112848; ENSMUSP00000108469; ENSMUSG00000046709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123664 Genomic DNA. No translation available.
AC125252 Genomic DNA. No translation available.
AC137121 Genomic DNA. No translation available.
AC160244 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9QN59.
SMRiE9QN59. Positions 41-459.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9QN59.
PRIDEiE9QN59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112848; ENSMUSP00000108469; ENSMUSG00000046709.

Organism-specific databases

MGIiMGI:1346863. Mapk10.

Phylogenomic databases

GeneTreeiENSGT00550000074271.
OMAiDCLFPAD.
OrthoDBiEOG7PCJGV.

Enzyme and pathway databases

ReactomeiREACT_288310. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_305463. Oxidative Stress Induced Senescence.
REACT_314186. FCERI mediated MAPK activation.
REACT_320943. Activation of the AP-1 family of transcription factors.

Miscellaneous databases

ChiTaRSiMapk10. mouse.
NextBioi35556055.
SOURCEiSearch...

Gene expression databases

BgeeiE9QN59.
ExpressionAtlasiE9QN59. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QN59_MOUSE
AccessioniPrimary (citable) accession number: E9QN59
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2011
Last sequence update: April 4, 2011
Last modified: March 31, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.