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E9QN59

- E9QN59_MOUSE

UniProt

E9QN59 - E9QN59_MOUSE

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Protein
Submitted name: Mitogen-activated protein kinase 10
Gene
Mapk10
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: InterPro
  3. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseSAAS annotations, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotations, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188530. FCERI mediated MAPK activation.
    REACT_188970. Oxidative Stress Induced Senescence.
    REACT_204811. Activation of the AP-1 family of transcription factors.
    REACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mitogen-activated protein kinase 10Imported
    Gene namesi
    Name:Mapk10Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1346863. Mapk10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. mitochondrion Source: MGI
    3. plasma membrane Source: MGI
    Complete GO annotation...

    PTM / Processingi

    Proteomic databases

    MaxQBiE9QN59.
    PRIDEiE9QN59.

    Expressioni

    Gene expression databases

    ArrayExpressiE9QN59.
    BgeeiE9QN59.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QN59.
    SMRiE9QN59. Positions 41-459.

    Family & Domainsi

    Sequence similaritiesi

    Contains protein kinase domain.SAAS annotations

    Phylogenomic databases

    GeneTreeiENSGT00550000074271.
    OMAiEVMNFEE.
    OrthoDBiEOG7PCJGV.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008351. MAPK_JNK.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01772. JNKMAPKINASE.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QN59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDTGVSGAP MKEMAQVMRI AEVTEDGRVF MSLHFLYYCS EPTLDVKIAF    50
    CQGFDKHVDV SSIAKHYNMS KSKVDNQFYS VEVGDSTFTV LKRYQNLKPI 100
    GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 150
    KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL 200
    YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM 250
    TPYVVTRYYR APEVILGMGY KENVDIWSVG CIMGEMVRHK ILFPGRDYID 300
    QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN RPKYAGLTFP KLFPDSLFPA 350
    DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN VWYDPAEVEA 400
    PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 450
    VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR 494
    Length:494
    Mass (Da):55,714
    Last modified:April 5, 2011 - v1
    Checksum:i0B07B6C2E5630B41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123664 Genomic DNA. No translation available.
    AC125252 Genomic DNA. No translation available.
    AC137121 Genomic DNA. No translation available.
    AC160244 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000112848; ENSMUSP00000108469; ENSMUSG00000046709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123664 Genomic DNA. No translation available.
    AC125252 Genomic DNA. No translation available.
    AC137121 Genomic DNA. No translation available.
    AC160244 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9QN59.
    SMRi E9QN59. Positions 41-459.
    ModBasei Search...

    Proteomic databases

    MaxQBi E9QN59.
    PRIDEi E9QN59.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112848 ; ENSMUSP00000108469 ; ENSMUSG00000046709 .

    Organism-specific databases

    MGIi MGI:1346863. Mapk10.

    Phylogenomic databases

    GeneTreei ENSGT00550000074271.
    OMAi EVMNFEE.
    OrthoDBi EOG7PCJGV.

    Enzyme and pathway databases

    Reactomei REACT_188530. FCERI mediated MAPK activation.
    REACT_188970. Oxidative Stress Induced Senescence.
    REACT_204811. Activation of the AP-1 family of transcription factors.
    REACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

    Miscellaneous databases

    ChiTaRSi MAPK10. mouse.
    NextBioi 35556055.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9QN59.
    Bgeei E9QN59.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008351. MAPK_JNK.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01772. JNKMAPKINASE.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QN59_MOUSE
    AccessioniPrimary (citable) accession number: E9QN59
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: September 3, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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