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Protein
Submitted name:

Axin-1

Gene

Axin1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-196299. Beta-catenin phosphorylation cascade.
R-MMU-201681. TCF dependent signaling in response to WNT.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Axin-1Imported
Gene namesi
Name:Axin1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1096327. Axin1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiE9QMJ8.

Expressioni

Gene expression databases

BgeeiE9QMJ8.
ExpressionAtlasiE9QMJ8. baseline and differential.
GenevisibleiE9QMJ8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073974.

Structurei

3D structure databases

ProteinModelPortaliE9QMJ8.
SMRiE9QMJ8. Positions 79-225, 785-868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 216124RGSInterPro annotationAdd
BLAST
Domaini786 – 86883DIXInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili394 – 42431Sequence analysisAdd
BLAST
Coiled coili710 – 73324Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00390000010011.
KOiK02157.
OMAiWHHFPPR.
OrthoDBiEOG79PJQ0.
TreeFamiTF315454.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR029797. AXIN1.
IPR014936. Axin_b-cat-bd.
IPR032101. Axin_TNKS_BD.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10845:SF11. PTHR10845:SF11. 1 hit.
PfamiPF16646. AXIN1_TNKS_BD. 1 hit.
PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QMJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPKMNVQE QGFPLDLGAS FTEDAPRPPV PGEEGELVST DSRPVNHSFC
60 70 80 90 100
SGKGTSIKSE TSTATPRRSD LDLGYEPEGS ASPTPPYLRW AESLHSLLDD
110 120 130 140 150
QDGISLFRTF LKQEGCADLL DFWFACSGFR KLEPCDSNEE KRLKLARAIY
160 170 180 190 200
RKYILDSNGI VSRQTKPATK SFIKDCVMKQ QIDPAMFDQA QTEIQSTMEE
210 220 230 240 250
NTYPSFLKSD IYLEYTRTGS ESPKVCSDQS SGSGTGKGMS GYLPTLNEDE
260 270 280 290 300
EWKCDQDADE DDGRDPLPPS RLTQKLLLET AAPRAPSSRR YNEGRELRYG
310 320 330 340 350
SWREPVNPYY VNSGYALAPA TSANDSEQQS LSSDADTLSL TDSSVDGIPP
360 370 380 390 400
YRIRKQHRRE MQESIQVNGR VPLPHIPRTY RMPKEIRVEP QKFAEELIHR
410 420 430 440 450
LEAVQRTREA EEKLEERLKR VRMEEEGEDG EMPSGPMASH KLPSVPAWHH
460 470 480 490 500
FPPRYVDMGC SGLRDAHEEN PESILDEHVQ RVMRTPGCQS PGPGHRSPDS
510 520 530 540 550
GHVAKTAVLG GTASGHGKHV PKLGLKLDTA GLHHHRHVHH HVHHNSARPK
560 570 580 590 600
EQMEAEVARR VQSSFSWGPE THGHAKPRSY SENAGTTLSA GDLAFGGKTS
610 620 630 640 650
APSKRNTKKA ESGKNANAEV PSTTEDAEKN QKIMQWIIEG EKEISRHRKA
660 670 680 690 700
GHGSSGLRKQ QAHESSRPLS IERPGAVHPW VSAQLRNSVQ PSHLFIQDPT
710 720 730 740 750
MPPNPAPNPL TQLEEARRRL EEEEKRANKL PSKQRYVQAV MQRGRTCVRP
760 770 780 790 800
ACAPVLSVVP AVSDLELSET ETKSQRKAGG GSAPPCDSIV VAYYFCGEPI
810 820 830 840 850
PYRTLVRGRA VTLGQFKELL TKKGSYRYYF KKVSDEFDCG VVFEEVREDE
860
AVLPVFEEKI IGKVEKVD
Length:868
Mass (Da):96,847
Last modified:April 5, 2011 - v1
Checksum:iD9FD3C42F0B24F75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126438 Genomic DNA. No translation available.
AC140047 Genomic DNA. No translation available.
RefSeqiNP_033863.2. NM_009733.2.
XP_006523578.1. XM_006523515.2.
UniGeneiMm.23684.

Genome annotation databases

EnsembliENSMUST00000074370; ENSMUSP00000073974; ENSMUSG00000024182.
GeneIDi12005.
KEGGimmu:12005.
UCSCiuc008bdm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126438 Genomic DNA. No translation available.
AC140047 Genomic DNA. No translation available.
RefSeqiNP_033863.2. NM_009733.2.
XP_006523578.1. XM_006523515.2.
UniGeneiMm.23684.

3D structure databases

ProteinModelPortaliE9QMJ8.
SMRiE9QMJ8. Positions 79-225, 785-868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073974.

Proteomic databases

PaxDbiE9QMJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074370; ENSMUSP00000073974; ENSMUSG00000024182.
GeneIDi12005.
KEGGimmu:12005.
UCSCiuc008bdm.2. mouse.

Organism-specific databases

CTDi8312.
MGIiMGI:1096327. Axin1.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00390000010011.
KOiK02157.
OMAiWHHFPPR.
OrthoDBiEOG79PJQ0.
TreeFamiTF315454.

Enzyme and pathway databases

ReactomeiR-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-196299. Beta-catenin phosphorylation cascade.
R-MMU-201681. TCF dependent signaling in response to WNT.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

ChiTaRSiAxin1. mouse.
NextBioi280195.
SOURCEiSearch...

Gene expression databases

BgeeiE9QMJ8.
ExpressionAtlasiE9QMJ8. baseline and differential.
GenevisibleiE9QMJ8. MM.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR029797. AXIN1.
IPR014936. Axin_b-cat-bd.
IPR032101. Axin_TNKS_BD.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10845:SF11. PTHR10845:SF11. 1 hit.
PfamiPF16646. AXIN1_TNKS_BD. 1 hit.
PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QMJ8_MOUSE
AccessioniPrimary (citable) accession number: E9QMJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.