ID E9QMJ5_MOUSE Unreviewed; 773 AA. AC E9QMJ5; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 27-MAR-2024, entry version 89. DE SubName: Full=Adhesion G protein-coupled receptor E5 {ECO:0000313|Ensembl:ENSMUSP00000105427.3}; GN Name=Adgre5 {ECO:0000313|Ensembl:ENSMUSP00000105427.3, GN ECO:0000313|MGI:MGI:1347095}; GN Synonyms=Cd97 {ECO:0000313|MGI:MGI:1347095}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000105427.3, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000105427.3, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105427.3, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000105427.3} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105427.3}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001156502.1; NM_001163030.1. DR AlphaFoldDB; E9QMJ5; -. DR SMR; E9QMJ5; -. DR MEROPS; P02.033; -. DR EPD; E9QMJ5; -. DR MaxQB; E9QMJ5; -. DR ProteomicsDB; 359683; -. DR Antibodypedia; 2852; 947 antibodies from 43 providers. DR DNASU; 26364; -. DR Ensembl; ENSMUST00000109802.3; ENSMUSP00000105427.3; ENSMUSG00000002885.15. DR GeneID; 26364; -. DR UCSC; uc012ggt.1; mouse. DR AGR; MGI:1347095; -. DR CTD; 976; -. DR MGI; MGI:1347095; Adgre5. DR VEuPathDB; HostDB:ENSMUSG00000002885; -. DR GeneTree; ENSGT00940000160578; -. DR HOGENOM; CLU_002753_3_7_1; -. DR OrthoDB; 1114672at2759; -. DR BioGRID-ORCS; 26364; 1 hit in 77 CRISPR screens. DR ChiTaRS; Adgre5; mouse. DR Proteomes; UP000000589; Chromosome 8. DR Bgee; ENSMUSG00000002885; Expressed in granulocyte and 70 other cell types or tissues. DR ExpressionAtlas; E9QMJ5; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR CDD; cd00054; EGF_CA; 3. DR Gene3D; 2.60.220.50; -; 1. DR Gene3D; 2.10.25.10; Laminin; 4. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR046338; GAIN_dom_sf. DR InterPro; IPR017981; GPCR_2-like_7TM. DR InterPro; IPR003056; GPCR_2_ADGRE2_ADGRE5. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR000203; GPS. DR PANTHER; PTHR12011:SF348; ADHESION G PROTEIN-COUPLED RECEPTOR E5; 1. DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF07645; EGF_CA; 3. DR Pfam; PF01825; GPS; 1. DR PRINTS; PR01278; CD97PROTEIN. DR PRINTS; PR00249; GPCRSECRETIN. DR SMART; SM00181; EGF; 4. DR SMART; SM00179; EGF_CA; 3. DR SMART; SM00303; GPS; 1. DR SUPFAM; SSF57196; EGF/Laminin; 3. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 3. DR PROSITE; PS50026; EGF_3; 3. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. DR PROSITE; PS50221; GPS; 1. DR Genevisible; E9QMJ5; MM. PE 1: Evidence at protein level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE- KW ProRule:PRU00076}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:E9QMJ5, KW ECO:0007829|MaxQB:E9QMJ5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..28 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 29..773 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003244809" FT TRANSMEM 490..509 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 521..538 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 550..582 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 594..611 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 631..655 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 676..699 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 705..728 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 69..107 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 120..158 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 169..207 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 484..729 FT /note="G-protein coupled receptors family 2 profile 2" FT /evidence="ECO:0000259|PROSITE:PS50261" FT REGION 754..773 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 773 AA; 85642 MW; 92C0A0F9FC11F68F CRC64; MRGVRCPGLL VVCILLSLSG AGTQKAESKN CAKWCPINSK CVSNRSCVCK PGFSSEKELI TNPAESCEDI NECLLPGFSC GDFAMCKNSE GSYTCVCNLG YKLLSGAESF VNESENTCQD VNECISGQNH CHQSTHCINK LGGYSCICRQ GWKPVPGSPN GPVSTVCEDV DECSSGQHQC HNSTVCKNTV GSYKCHCRPG WKPTSGSLRG PDTICQEPPF PTWTLLPTAH SQTLLRFSVE VQNLLRDFNP ATVNYTIQKL IEAVDKLLED PMETETQQVA AQLLSNLEQS LRTLAQFLPK GPFTYTSPSN TELSLMVKEQ DNKDVTTVHH GQTWMELDWA VTAGAKISEN GSSVAGILSS PNMEKLLGNT PLNLEQRRAS LEDFYGSPIP SVSLKLLSNI NSVFLTNTNT EKLASNVTFK FDFTSVESIE PRHELICAFW KAHNGNGYWD TDGCSMNGTG FCHCNHLTSF AILMAQYHVQ DPRLELITKV GLLLSLICLL LCILTFLLVK PIQSSRTMVH LHLCICLFLG SIIFLVGVEN EGGEVGLRCR LVAVMLHFCF LAAFCWMALE GVELYFLVVR VFQGQGLSTW QRCLIGYGVP LLIVAISMAV VKMDGYGHAT YCWLDFRKQG FLWSFSGPVA FIIFCNAAIF VITVWKLTKK FSEINPNMKK LRKARVLTIT SIAQLLVLGC TWGFGLFLFN PHSTWLSYIF TLLNCLQGLF LYVMLCLLNK KVREEYWKWA CMVTGSKYTE FNSSTTGTGT SQTRALRSSE SGM //