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Protein
Submitted name:

Adhesion G protein-coupled receptor E5

Gene

Adgre5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor E5Imported
Gene namesi
Name:Adgre5Imported
Synonyms:Cd97Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1347095 Adgre5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei490 – 509HelicalSequence analysisAdd BLAST20
Transmembranei521 – 538HelicalSequence analysisAdd BLAST18
Transmembranei550 – 582HelicalSequence analysisAdd BLAST33
Transmembranei594 – 611HelicalSequence analysisAdd BLAST18
Transmembranei631 – 655HelicalSequence analysisAdd BLAST25
Transmembranei676 – 699HelicalSequence analysisAdd BLAST24
Transmembranei705 – 728HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500324480929 – 773Sequence analysisAdd BLAST745

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9QMJ5
PRIDEiE9QMJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000002885
ExpressionAtlasiE9QMJ5 baseline and differential
GenevisibleiE9QMJ5 MM

Structurei

3D structure databases

ProteinModelPortaliE9QMJ5
SMRiE9QMJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 107EGF-likeInterPro annotationAdd BLAST39
Domaini120 – 158EGF-likeInterPro annotationAdd BLAST39
Domaini169 – 207EGF-likeInterPro annotationAdd BLAST39
Domaini434 – 479GPSInterPro annotationAdd BLAST46
Domaini484 – 729G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST246

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140800

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR017981 GPCR_2-like
IPR003056 GPCR_2_CD97
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 3 hits
PF01825 GPS, 1 hit
PRINTSiPR01278 CD97PROTEIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 3 hits
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

Sequencei

Sequence statusi: Complete.

E9QMJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGVRCPGLL VVCILLSLSG AGTQKAESKN CAKWCPINSK CVSNRSCVCK
60 70 80 90 100
PGFSSEKELI TNPAESCEDI NECLLPGFSC GDFAMCKNSE GSYTCVCNLG
110 120 130 140 150
YKLLSGAESF VNESENTCQD VNECISGQNH CHQSTHCINK LGGYSCICRQ
160 170 180 190 200
GWKPVPGSPN GPVSTVCEDV DECSSGQHQC HNSTVCKNTV GSYKCHCRPG
210 220 230 240 250
WKPTSGSLRG PDTICQEPPF PTWTLLPTAH SQTLLRFSVE VQNLLRDFNP
260 270 280 290 300
ATVNYTIQKL IEAVDKLLED PMETETQQVA AQLLSNLEQS LRTLAQFLPK
310 320 330 340 350
GPFTYTSPSN TELSLMVKEQ DNKDVTTVHH GQTWMELDWA VTAGAKISEN
360 370 380 390 400
GSSVAGILSS PNMEKLLGNT PLNLEQRRAS LEDFYGSPIP SVSLKLLSNI
410 420 430 440 450
NSVFLTNTNT EKLASNVTFK FDFTSVESIE PRHELICAFW KAHNGNGYWD
460 470 480 490 500
TDGCSMNGTG FCHCNHLTSF AILMAQYHVQ DPRLELITKV GLLLSLICLL
510 520 530 540 550
LCILTFLLVK PIQSSRTMVH LHLCICLFLG SIIFLVGVEN EGGEVGLRCR
560 570 580 590 600
LVAVMLHFCF LAAFCWMALE GVELYFLVVR VFQGQGLSTW QRCLIGYGVP
610 620 630 640 650
LLIVAISMAV VKMDGYGHAT YCWLDFRKQG FLWSFSGPVA FIIFCNAAIF
660 670 680 690 700
VITVWKLTKK FSEINPNMKK LRKARVLTIT SIAQLLVLGC TWGFGLFLFN
710 720 730 740 750
PHSTWLSYIF TLLNCLQGLF LYVMLCLLNK KVREEYWKWA CMVTGSKYTE
760 770
FNSSTTGTGT SQTRALRSSE SGM
Length:773
Mass (Da):85,642
Last modified:April 5, 2011 - v1
Checksum:i92C0A0F9FC11F68F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164432 Genomic DNA No translation available.
RefSeqiNP_001156502.1, NM_001163030.1
UniGeneiMm.334648

Genome annotation databases

EnsembliENSMUST00000109802; ENSMUSP00000105427; ENSMUSG00000002885
GeneIDi26364
UCSCiuc012ggt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QMJ5_MOUSE
AccessioniPrimary (citable) accession number: E9QMJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health