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E9QMD3

- E9QMD3_MOUSE

UniProt

E9QMD3 - E9QMD3_MOUSE

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Protein
Submitted name:

Zinc finger homeobox protein 3

Gene
Zfhx3
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. transcription regulatory region DNA binding Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. negative regulation of myoblast differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of myoblast differentiation Source: Ensembl
  6. regulation of neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger homeobox protein 3Imported
Gene namesi
Name:Zfhx3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99948. Zfhx3.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. nucleus Source: UniProtKB-SubCell
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiE9QMD3.

Expressioni

Gene expression databases

BgeeiE9QMD3.

Structurei

3D structure databases

ProteinModelPortaliE9QMD3.
SMRiE9QMD3. Positions 2153-2214, 2254-2312, 2645-2707, 3028-3073.

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063717.
KOiK09378.
OMAiSVGMPPL.
OrthoDBiEOG7FR7FH.
TreeFamiTF323288.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QMD3-1 [UniParc]FASTAAdd to Basket

« Hide

MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL     50
DSLRAPFNER LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP 100
GTHPPPALRE ESASDTSEEG EEESDVENLA GEIVYQPDGS AYIVESLSQL 150
AQSGAACGSS SGSGAVPSLF LNSLPGVGGK QGDPSCAAPV YPQIINTFHI 200
ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS 250
AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 300
AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP 350
LVSTANLIGP GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL 400
LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GDKQESGGHQ 450
DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE EEEEEEEEEE EGCKGLFPND 500
LEEELEDRPS EESGAPAGGS SKKDLALSNQ SISNSPLMPN VLQTLSRGPA 550
STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS 600
ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGECPSGSG VECPKCDTVL 650
GSSRSLGGHM TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG 700
SCVYCKSGQP HPRLARGESY TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK 750
HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA AAAAANIGSS CGAPSPTKPK 800
TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM TQIQHNRHLG 850
LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM 900
AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV 950
CNKFTTDNLD MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF 1000
QLHCKTDKHV QKYQLVAHIK EGGKANEWRL KCVAIGNPVH LKCNACDYYT 1050
NSLEKLRLHT VNSRHEASLK LYKHLQQHES GVEGESCYYH CVLCNYSTKA 1100
KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF TIRRCPSTDP 1150
EEAVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP 1200
ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV 1250
HAMTQHSVQP LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT 1300
APEMVMPSSM FLPAAAADRD GNSTLEEAGK QPEASEDPGK NILPPASMEH 1350
GGDLKPTSAD PSCGREDSGF LCWKKGCNQV FKTSATLQTH FNEVHAKRPQ 1400
LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT 1450
FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE 1500
EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD 1550
PSRPYKCTVC KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS 1600
PDNKPFKCNT CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGNSNGTG 1650
NSGGVSLSSS TPSPVGSSGA NNTFTATNPS SAAMAPSVNA LSQVPPESVV 1700
MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ QQQQQQAQTL 1750
AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH 1800
LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KAQVQIPQQS 1850
HQQILQQQQQ QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE 1900
GPEGAEGNTG PKESLPDASK AKEKKDLAPG GGSEGTMLPP RIASDARGNA 1950
TKALLENFGF ELVIQYNENK QKAQKKNGKA EQGGESLEKL ECDSCGKLFS 2000
NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR PQTPEPPPPP 2050
PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME 2100
LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ 2150
QNKRPRTRIT DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF 2200
RNTLFKERQR NKDSPYNFSN PPITSLEELK IDSRPPSPEP QKQEYWGSKR 2250
SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE QLSNLLNLPT RVIVVWFQNA 2300
RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC SLVFQRIFDL 2350
IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST 2400
PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN 2450
QTQEKQGQPK PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ 2500
CPLPQSSPSP SQLSHLPLKP LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS 2550
FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD MPFMLFDPSN PLLASQLLSG 2600
AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS GTGGEEPQRD 2650
KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN 2700
TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA 2750
GYNLTLSAML LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT 2800
MELSPRTLLS PSSIKVEGIE DFESPSMSSV NLNFDQTKLD NDDCSSVNTA 2850
ITDTTTGDEG NADNDSATGI ATETKSSAPN EGLTKAAMMA MSEYEDRLSS 2900
GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG SAGKSGDGGD 2950
RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV 3000
WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH 3050
IFSQQHISKV KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG 3100
LAAQQQGMFD NAPLQALNLP TTYPALQGIP PVLLPGLNSP SLPGFTPANT 3150
ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK PSSASLSSPT PAQATMAMAP 3200
QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD GEKGKEKEKA 3250
HKGKGEPLPV PKKEKGEAPP AATATISAPL PAMEYAVDPA QLQALQAALT 3300
SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP 3350
ALSQALMGLS PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQRQLQQQ 3400
QQQQQQKVQQ QQQQQQQPKA SQTPVPQGPA SPDKDPAKES PKPEEQKNVP 3450
REVSPLLPKP PEEPEAESKS ASADSLCDPF IVPKVQYKLV CRKCQAGFGD 3500
EEAARSHLKS LCCFGQSVVN LQEMVLHVPT GSGGSGGGGG GSGGGGGSYH 3550
CLACESALCG EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD 3600
PSTASTSQSA AHSNDSPPPP SAAPSSSASP HASRKSWPPV GSRASAAKPP 3650
SFPPLSSSST VTSSSCSTSG VQPSMPTDDY SEESDTDLSQ KSDGPASPVE 3700
GPKDPSCPKD SGLTSVGTDT FRL 3723
Length:3,723
Mass (Da):406,106
Last modified:April 5, 2011 - v1
Checksum:i0098F351856FD5AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC122873 Genomic DNA. No translation available.
AC127258 Genomic DNA. No translation available.
AC134561 Genomic DNA. No translation available.
RefSeqiNP_031522.2. NM_007496.2.
XP_006530648.1. XM_006530585.1.
UniGeneiMm.416972.
Mm.477670.

Genome annotation databases

EnsembliENSMUST00000043896; ENSMUSP00000044612; ENSMUSG00000038872.
GeneIDi11906.
KEGGimmu:11906.
UCSCiuc009nid.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC122873 Genomic DNA. No translation available.
AC127258 Genomic DNA. No translation available.
AC134561 Genomic DNA. No translation available.
RefSeqi NP_031522.2. NM_007496.2.
XP_006530648.1. XM_006530585.1.
UniGenei Mm.416972.
Mm.477670.

3D structure databases

ProteinModelPortali E9QMD3.
SMRi E9QMD3. Positions 2153-2214, 2254-2312, 2645-2707, 3028-3073.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9QMD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043896 ; ENSMUSP00000044612 ; ENSMUSG00000038872 .
GeneIDi 11906.
KEGGi mmu:11906.
UCSCi uc009nid.1. mouse.

Organism-specific databases

CTDi 463.
MGIi MGI:99948. Zfhx3.

Phylogenomic databases

GeneTreei ENSGT00530000063717.
KOi K09378.
OMAi SVGMPPL.
OrthoDBi EOG7FR7FH.
TreeFami TF323288.

Miscellaneous databases

ChiTaRSi ZFHX3. mouse.
NextBioi 279957.
SOURCEi Search...

Gene expression databases

Bgeei E9QMD3.

Family and domain databases

Gene3Di 1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view ]
Pfami PF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 4 hits.
PROSITEi PS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QMD3_MOUSE
AccessioniPrimary (citable) accession number: E9QMD3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi