E9QMD3 (E9QMD3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Zinc finger homeobox protein 3 Ensembl ENSMUSP00000044612

Gene names

Name:

Zfhx3 Ensembl ENSMUSP00000044612 MGI 99948

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000044612

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	3723 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000682.
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000044612

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682
Domain	Homeobox RuleBase RU000682
Ligand	DNA-binding RuleBase RU000682
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of myoblast differentiation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of myoblast differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrion Inferred from direct assay PubMed 14651853. Source: MGI transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9QMD3 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 0098F351856FD5AA	FASTA	3,723	406,106
	10 20 30 40 50 60 MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL DSLRAPFNER 70 80 90 100 110 120 LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP GTHPPPALRE ESASDTSEEG 130 140 150 160 170 180 EEESDVENLA GEIVYQPDGS AYIVESLSQL AQSGAACGSS SGSGAVPSLF LNSLPGVGGK 190 200 210 220 230 240 QGDPSCAAPV YPQIINTFHI ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS 250 260 270 280 290 300 NKDYLNSDGS AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 310 320 330 340 350 360 AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP LVSTANLIGP 370 380 390 400 410 420 GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL LNLGGLTSSV LKTPITSVPL 430 440 450 460 470 480 GPLASSPTKS SEGKDSGAAE GDKQESGGHQ DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE 490 500 510 520 530 540 EEEEEEEEEE EGCKGLFPND LEEELEDRPS EESGAPAGGS SKKDLALSNQ SISNSPLMPN 550 560 570 580 590 600 VLQTLSRGPA STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS 610 620 630 640 650 660 ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGECPSGSG VECPKCDTVL GSSRSLGGHM 670 680 690 700 710 720 TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG SCVYCKSGQP HPRLARGESY 730 740 750 760 770 780 TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA 790 800 810 820 830 840 AAAAANIGSS CGAPSPTKPK TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM 850 860 870 880 890 900 TQIQHNRHLG LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM 910 920 930 940 950 960 AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV CNKFTTDNLD 970 980 990 1000 1010 1020 MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF QLHCKTDKHV QKYQLVAHIK 1030 1040 1050 1060 1070 1080 EGGKANEWRL KCVAIGNPVH LKCNACDYYT NSLEKLRLHT VNSRHEASLK LYKHLQQHES 1090 1100 1110 1120 1130 1140 GVEGESCYYH CVLCNYSTKA KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF 1150 1160 1170 1180 1190 1200 TIRRCPSTDP EEAVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP 1210 1220 1230 1240 1250 1260 ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP 1270 1280 1290 1300 1310 1320 LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT APEMVMPSSM FLPAAAADRD 1330 1340 1350 1360 1370 1380 GNSTLEEAGK QPEASEDPGK NILPPASMEH GGDLKPTSAD PSCGREDSGF LCWKKGCNQV 1390 1400 1410 1420 1430 1440 FKTSATLQTH FNEVHAKRPQ LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM 1450 1460 1470 1480 1490 1500 CCLCQRSFRT FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE 1510 1520 1530 1540 1550 1560 EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC 1570 1580 1590 1600 1610 1620 KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT CNVAYSQSST 1630 1640 1650 1660 1670 1680 LEIHMRSVLH QTKARAAKLE AASGNSNGTG NSGGVSLSSS TPSPVGSSGA NNTFTATNPS 1690 1700 1710 1720 1730 1740 SAAMAPSVNA LSQVPPESVV MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ 1750 1760 1770 1780 1790 1800 QQQQQQAQTL AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH 1810 1820 1830 1840 1850 1860 LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KAQVQIPQQS HQQILQQQQQ 1870 1880 1890 1900 1910 1920 QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE GPEGAEGNTG PKESLPDASK 1930 1940 1950 1960 1970 1980 AKEKKDLAPG GGSEGTMLPP RIASDARGNA TKALLENFGF ELVIQYNENK QKAQKKNGKA 1990 2000 2010 2020 2030 2040 EQGGESLEKL ECDSCGKLFS NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR 2050 2060 2070 2080 2090 2100 PQTPEPPPPP PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME 2110 2120 2130 2140 2150 2160 LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ QNKRPRTRIT 2170 2180 2190 2200 2210 2220 DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF RNTLFKERQR NKDSPYNFSN 2230 2240 2250 2260 2270 2280 PPITSLEELK IDSRPPSPEP QKQEYWGSKR SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE 2290 2300 2310 2320 2330 2340 QLSNLLNLPT RVIVVWFQNA RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC 2350 2360 2370 2380 2390 2400 SLVFQRIFDL IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST 2410 2420 2430 2440 2450 2460 PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN QTQEKQGQPK 2470 2480 2490 2500 2510 2520 PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ CPLPQSSPSP SQLSHLPLKP 2530 2540 2550 2560 2570 2580 LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD 2590 2600 2610 2620 2630 2640 MPFMLFDPSN PLLASQLLSG AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS 2650 2660 2670 2680 2690 2700 GTGGEEPQRD KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN 2710 2720 2730 2740 2750 2760 TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA GYNLTLSAML 2770 2780 2790 2800 2810 2820 LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT MELSPRTLLS PSSIKVEGIE 2830 2840 2850 2860 2870 2880 DFESPSMSSV NLNFDQTKLD NDDCSSVNTA ITDTTTGDEG NADNDSATGI ATETKSSAPN 2890 2900 2910 2920 2930 2940 EGLTKAAMMA MSEYEDRLSS GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG 2950 2960 2970 2980 2990 3000 SAGKSGDGGD RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV 3010 3020 3030 3040 3050 3060 WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH IFSQQHISKV 3070 3080 3090 3100 3110 3120 KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG LAAQQQGMFD NAPLQALNLP 3130 3140 3150 3160 3170 3180 TTYPALQGIP PVLLPGLNSP SLPGFTPANT ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK 3190 3200 3210 3220 3230 3240 PSSASLSSPT PAQATMAMAP QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD 3250 3260 3270 3280 3290 3300 GEKGKEKEKA HKGKGEPLPV PKKEKGEAPP AATATISAPL PAMEYAVDPA QLQALQAALT 3310 3320 3330 3340 3350 3360 SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP ALSQALMGLS 3370 3380 3390 3400 3410 3420 PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQRQLQQQ QQQQQQKVQQ QQQQQQQPKA 3430 3440 3450 3460 3470 3480 SQTPVPQGPA SPDKDPAKES PKPEEQKNVP REVSPLLPKP PEEPEAESKS ASADSLCDPF 3490 3500 3510 3520 3530 3540 IVPKVQYKLV CRKCQAGFGD EEAARSHLKS LCCFGQSVVN LQEMVLHVPT GSGGSGGGGG 3550 3560 3570 3580 3590 3600 GSGGGGGSYH CLACESALCG EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD 3610 3620 3630 3640 3650 3660 PSTASTSQSA AHSNDSPPPP SAAPSSSASP HASRKSWPPV GSRASAAKPP SFPPLSSSST 3670 3680 3690 3700 3710 3720 VTSSSCSTSG VQPSMPTDDY SEESDTDLSQ KSDGPASPVE GPKDPSCPKD SGLTSVGTDT FRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000044612.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000044612.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC122873 Genomic DNA. No translation available. AC127258 Genomic DNA. No translation available. AC134561 Genomic DNA. No translation available.
IPI	IPI00475055.
RefSeq	NP_031522.2. NM_007496.2.
UniGene	Mm.416972. Mm.477670.
3D structure databases
ProteinModelPortal	E9QMD3.
SMR	E9QMD3. Positions 2153-2214, 2254-2312, 2645-2707, 3028-3073.
ModBase	Search...
Proteomic databases
PRIDE	E9QMD3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000043896; ENSMUSP00000044612; ENSMUSG00000038872.
GeneID	11906.
KEGG	mmu:11906.
Organism-specific databases
CTD	463.
MGI	MGI:99948. Zfhx3.
Phylogenomic databases
GeneTree	ENSGT00530000063717.
KO	K09378.
OMA	SMDAMEI.
Gene expression databases
Bgee	E9QMD3.
Family and domain databases
Gene3D	1.10.10.60. 4 hits. 3.30.160.60. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. IPR003604. Znf_U1. [Graphical view]
Pfam	PF00046. Homeobox. 4 hits. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00389. HOX. 4 hits. SM00355. ZnF_C2H2. 23 hits. SM00451. ZnF_U1. 7 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 4 hits.
PROSITE	PS00027. HOMEOBOX_1. 2 hits. PS50071. HOMEOBOX_2. 4 hits. PS00028. ZINC_FINGER_C2H2_1. 15 hits. PS50157. ZINC_FINGER_C2H2_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZFHX3. mouse.
NextBio	279957.
SOURCE	Search...

Entry information

Entry name

E9QMD3_MOUSE

Accession

Primary (citable) accession number: E9QMD3

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)