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E9QMD3

- E9QMD3_MOUSE

UniProt

E9QMD3 - E9QMD3_MOUSE

Protein
Submitted name:

Zinc finger homeobox protein 3

Gene

Zfhx3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. transcription regulatory region DNA binding Source: Ensembl
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. negative regulation of myoblast differentiation Source: Ensembl
    4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. positive regulation of myoblast differentiation Source: Ensembl
    6. regulation of neuron differentiation Source: Ensembl

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Zinc finger homeobox protein 3Imported
    Gene namesi
    Name:Zfhx3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:99948. Zfhx3.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. mitochondrion Source: MGI
    2. nucleus Source: UniProtKB-SubCell
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiE9QMD3.

    Expressioni

    Gene expression databases

    BgeeiE9QMD3.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QMD3.
    SMRiE9QMD3. Positions 2153-2214, 2254-2312, 2645-2707, 3028-3073.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    HomeoboxUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000063717.
    KOiK09378.
    OMAiSVGMPPL.
    OrthoDBiEOG7FR7FH.
    TreeFamiTF323288.

    Family and domain databases

    Gene3Di1.10.10.60. 4 hits.
    3.30.160.60. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR003604. Znf_U1.
    [Graphical view]
    PfamiPF00046. Homeobox. 4 hits.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 4 hits.
    SM00355. ZnF_C2H2. 23 hits.
    SM00451. ZnF_U1. 7 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 4 hits.
    PROSITEiPS00027. HOMEOBOX_1. 2 hits.
    PS50071. HOMEOBOX_2. 4 hits.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QMD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL     50
    DSLRAPFNER LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP 100
    GTHPPPALRE ESASDTSEEG EEESDVENLA GEIVYQPDGS AYIVESLSQL 150
    AQSGAACGSS SGSGAVPSLF LNSLPGVGGK QGDPSCAAPV YPQIINTFHI 200
    ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS 250
    AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 300
    AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP 350
    LVSTANLIGP GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL 400
    LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GDKQESGGHQ 450
    DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE EEEEEEEEEE EGCKGLFPND 500
    LEEELEDRPS EESGAPAGGS SKKDLALSNQ SISNSPLMPN VLQTLSRGPA 550
    STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS 600
    ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGECPSGSG VECPKCDTVL 650
    GSSRSLGGHM TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG 700
    SCVYCKSGQP HPRLARGESY TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK 750
    HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA AAAAANIGSS CGAPSPTKPK 800
    TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM TQIQHNRHLG 850
    LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM 900
    AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV 950
    CNKFTTDNLD MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF 1000
    QLHCKTDKHV QKYQLVAHIK EGGKANEWRL KCVAIGNPVH LKCNACDYYT 1050
    NSLEKLRLHT VNSRHEASLK LYKHLQQHES GVEGESCYYH CVLCNYSTKA 1100
    KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF TIRRCPSTDP 1150
    EEAVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP 1200
    ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV 1250
    HAMTQHSVQP LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT 1300
    APEMVMPSSM FLPAAAADRD GNSTLEEAGK QPEASEDPGK NILPPASMEH 1350
    GGDLKPTSAD PSCGREDSGF LCWKKGCNQV FKTSATLQTH FNEVHAKRPQ 1400
    LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT 1450
    FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE 1500
    EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD 1550
    PSRPYKCTVC KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS 1600
    PDNKPFKCNT CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGNSNGTG 1650
    NSGGVSLSSS TPSPVGSSGA NNTFTATNPS SAAMAPSVNA LSQVPPESVV 1700
    MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ QQQQQQAQTL 1750
    AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH 1800
    LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KAQVQIPQQS 1850
    HQQILQQQQQ QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE 1900
    GPEGAEGNTG PKESLPDASK AKEKKDLAPG GGSEGTMLPP RIASDARGNA 1950
    TKALLENFGF ELVIQYNENK QKAQKKNGKA EQGGESLEKL ECDSCGKLFS 2000
    NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR PQTPEPPPPP 2050
    PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME 2100
    LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ 2150
    QNKRPRTRIT DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF 2200
    RNTLFKERQR NKDSPYNFSN PPITSLEELK IDSRPPSPEP QKQEYWGSKR 2250
    SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE QLSNLLNLPT RVIVVWFQNA 2300
    RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC SLVFQRIFDL 2350
    IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST 2400
    PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN 2450
    QTQEKQGQPK PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ 2500
    CPLPQSSPSP SQLSHLPLKP LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS 2550
    FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD MPFMLFDPSN PLLASQLLSG 2600
    AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS GTGGEEPQRD 2650
    KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN 2700
    TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA 2750
    GYNLTLSAML LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT 2800
    MELSPRTLLS PSSIKVEGIE DFESPSMSSV NLNFDQTKLD NDDCSSVNTA 2850
    ITDTTTGDEG NADNDSATGI ATETKSSAPN EGLTKAAMMA MSEYEDRLSS 2900
    GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG SAGKSGDGGD 2950
    RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV 3000
    WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH 3050
    IFSQQHISKV KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG 3100
    LAAQQQGMFD NAPLQALNLP TTYPALQGIP PVLLPGLNSP SLPGFTPANT 3150
    ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK PSSASLSSPT PAQATMAMAP 3200
    QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD GEKGKEKEKA 3250
    HKGKGEPLPV PKKEKGEAPP AATATISAPL PAMEYAVDPA QLQALQAALT 3300
    SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP 3350
    ALSQALMGLS PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQRQLQQQ 3400
    QQQQQQKVQQ QQQQQQQPKA SQTPVPQGPA SPDKDPAKES PKPEEQKNVP 3450
    REVSPLLPKP PEEPEAESKS ASADSLCDPF IVPKVQYKLV CRKCQAGFGD 3500
    EEAARSHLKS LCCFGQSVVN LQEMVLHVPT GSGGSGGGGG GSGGGGGSYH 3550
    CLACESALCG EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD 3600
    PSTASTSQSA AHSNDSPPPP SAAPSSSASP HASRKSWPPV GSRASAAKPP 3650
    SFPPLSSSST VTSSSCSTSG VQPSMPTDDY SEESDTDLSQ KSDGPASPVE 3700
    GPKDPSCPKD SGLTSVGTDT FRL 3723
    Length:3,723
    Mass (Da):406,106
    Last modified:April 5, 2011 - v1
    Checksum:i0098F351856FD5AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122873 Genomic DNA. No translation available.
    AC127258 Genomic DNA. No translation available.
    AC134561 Genomic DNA. No translation available.
    RefSeqiNP_031522.2. NM_007496.2.
    XP_006530648.1. XM_006530585.1.
    UniGeneiMm.416972.
    Mm.477670.

    Genome annotation databases

    EnsembliENSMUST00000043896; ENSMUSP00000044612; ENSMUSG00000038872.
    GeneIDi11906.
    KEGGimmu:11906.
    UCSCiuc009nid.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122873 Genomic DNA. No translation available.
    AC127258 Genomic DNA. No translation available.
    AC134561 Genomic DNA. No translation available.
    RefSeqi NP_031522.2. NM_007496.2.
    XP_006530648.1. XM_006530585.1.
    UniGenei Mm.416972.
    Mm.477670.

    3D structure databases

    ProteinModelPortali E9QMD3.
    SMRi E9QMD3. Positions 2153-2214, 2254-2312, 2645-2707, 3028-3073.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9QMD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043896 ; ENSMUSP00000044612 ; ENSMUSG00000038872 .
    GeneIDi 11906.
    KEGGi mmu:11906.
    UCSCi uc009nid.1. mouse.

    Organism-specific databases

    CTDi 463.
    MGIi MGI:99948. Zfhx3.

    Phylogenomic databases

    GeneTreei ENSGT00530000063717.
    KOi K09378.
    OMAi SVGMPPL.
    OrthoDBi EOG7FR7FH.
    TreeFami TF323288.

    Miscellaneous databases

    ChiTaRSi ZFHX3. mouse.
    NextBioi 279957.
    SOURCEi Search...

    Gene expression databases

    Bgeei E9QMD3.

    Family and domain databases

    Gene3Di 1.10.10.60. 4 hits.
    3.30.160.60. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR003604. Znf_U1.
    [Graphical view ]
    Pfami PF00046. Homeobox. 4 hits.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 4 hits.
    SM00355. ZnF_C2H2. 23 hits.
    SM00451. ZnF_U1. 7 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 4 hits.
    PROSITEi PS00027. HOMEOBOX_1. 2 hits.
    PS50071. HOMEOBOX_2. 4 hits.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QMD3_MOUSE
    AccessioniPrimary (citable) accession number: E9QMD3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3