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E9QMD3

- E9QMD3_MOUSE

UniProt

E9QMD3 - E9QMD3_MOUSE

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Protein
Submitted name:

Zinc finger homeobox protein 3

Gene

Zfhx3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. transcription regulatory region DNA binding Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. negative regulation of myoblast differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of myoblast differentiation Source: Ensembl
  6. regulation of neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger homeobox protein 3Imported
Gene namesi
Name:Zfhx3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99948. Zfhx3.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. nucleus Source: UniProtKB-SubCell
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiE9QMD3.
PRIDEiE9QMD3.

Expressioni

Gene expression databases

BgeeiE9QMD3.

Structurei

3D structure databases

ProteinModelPortaliE9QMD3.
SMRiE9QMD3. Positions 2153-2214, 2254-2312, 2645-2707, 3028-3073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063717.
KOiK09378.
OMAiSVGMPPL.
OrthoDBiEOG7FR7FH.
TreeFamiTF323288.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QMD3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL
60 70 80 90 100
DSLRAPFNER LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP
110 120 130 140 150
GTHPPPALRE ESASDTSEEG EEESDVENLA GEIVYQPDGS AYIVESLSQL
160 170 180 190 200
AQSGAACGSS SGSGAVPSLF LNSLPGVGGK QGDPSCAAPV YPQIINTFHI
210 220 230 240 250
ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS
260 270 280 290 300
AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH
310 320 330 340 350
AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP
360 370 380 390 400
LVSTANLIGP GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL
410 420 430 440 450
LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GDKQESGGHQ
460 470 480 490 500
DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE EEEEEEEEEE EGCKGLFPND
510 520 530 540 550
LEEELEDRPS EESGAPAGGS SKKDLALSNQ SISNSPLMPN VLQTLSRGPA
560 570 580 590 600
STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS
610 620 630 640 650
ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGECPSGSG VECPKCDTVL
660 670 680 690 700
GSSRSLGGHM TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG
710 720 730 740 750
SCVYCKSGQP HPRLARGESY TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK
760 770 780 790 800
HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA AAAAANIGSS CGAPSPTKPK
810 820 830 840 850
TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM TQIQHNRHLG
860 870 880 890 900
LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM
910 920 930 940 950
AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV
960 970 980 990 1000
CNKFTTDNLD MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF
1010 1020 1030 1040 1050
QLHCKTDKHV QKYQLVAHIK EGGKANEWRL KCVAIGNPVH LKCNACDYYT
1060 1070 1080 1090 1100
NSLEKLRLHT VNSRHEASLK LYKHLQQHES GVEGESCYYH CVLCNYSTKA
1110 1120 1130 1140 1150
KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF TIRRCPSTDP
1160 1170 1180 1190 1200
EEAVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP
1210 1220 1230 1240 1250
ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV
1260 1270 1280 1290 1300
HAMTQHSVQP LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT
1310 1320 1330 1340 1350
APEMVMPSSM FLPAAAADRD GNSTLEEAGK QPEASEDPGK NILPPASMEH
1360 1370 1380 1390 1400
GGDLKPTSAD PSCGREDSGF LCWKKGCNQV FKTSATLQTH FNEVHAKRPQ
1410 1420 1430 1440 1450
LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT
1460 1470 1480 1490 1500
FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE
1510 1520 1530 1540 1550
EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD
1560 1570 1580 1590 1600
PSRPYKCTVC KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS
1610 1620 1630 1640 1650
PDNKPFKCNT CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGNSNGTG
1660 1670 1680 1690 1700
NSGGVSLSSS TPSPVGSSGA NNTFTATNPS SAAMAPSVNA LSQVPPESVV
1710 1720 1730 1740 1750
MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ QQQQQQAQTL
1760 1770 1780 1790 1800
AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH
1810 1820 1830 1840 1850
LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KAQVQIPQQS
1860 1870 1880 1890 1900
HQQILQQQQQ QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE
1910 1920 1930 1940 1950
GPEGAEGNTG PKESLPDASK AKEKKDLAPG GGSEGTMLPP RIASDARGNA
1960 1970 1980 1990 2000
TKALLENFGF ELVIQYNENK QKAQKKNGKA EQGGESLEKL ECDSCGKLFS
2010 2020 2030 2040 2050
NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR PQTPEPPPPP
2060 2070 2080 2090 2100
PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME
2110 2120 2130 2140 2150
LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ
2160 2170 2180 2190 2200
QNKRPRTRIT DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF
2210 2220 2230 2240 2250
RNTLFKERQR NKDSPYNFSN PPITSLEELK IDSRPPSPEP QKQEYWGSKR
2260 2270 2280 2290 2300
SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE QLSNLLNLPT RVIVVWFQNA
2310 2320 2330 2340 2350
RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC SLVFQRIFDL
2360 2370 2380 2390 2400
IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST
2410 2420 2430 2440 2450
PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN
2460 2470 2480 2490 2500
QTQEKQGQPK PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ
2510 2520 2530 2540 2550
CPLPQSSPSP SQLSHLPLKP LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS
2560 2570 2580 2590 2600
FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD MPFMLFDPSN PLLASQLLSG
2610 2620 2630 2640 2650
AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS GTGGEEPQRD
2660 2670 2680 2690 2700
KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN
2710 2720 2730 2740 2750
TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA
2760 2770 2780 2790 2800
GYNLTLSAML LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT
2810 2820 2830 2840 2850
MELSPRTLLS PSSIKVEGIE DFESPSMSSV NLNFDQTKLD NDDCSSVNTA
2860 2870 2880 2890 2900
ITDTTTGDEG NADNDSATGI ATETKSSAPN EGLTKAAMMA MSEYEDRLSS
2910 2920 2930 2940 2950
GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG SAGKSGDGGD
2960 2970 2980 2990 3000
RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV
3010 3020 3030 3040 3050
WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH
3060 3070 3080 3090 3100
IFSQQHISKV KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG
3110 3120 3130 3140 3150
LAAQQQGMFD NAPLQALNLP TTYPALQGIP PVLLPGLNSP SLPGFTPANT
3160 3170 3180 3190 3200
ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK PSSASLSSPT PAQATMAMAP
3210 3220 3230 3240 3250
QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD GEKGKEKEKA
3260 3270 3280 3290 3300
HKGKGEPLPV PKKEKGEAPP AATATISAPL PAMEYAVDPA QLQALQAALT
3310 3320 3330 3340 3350
SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP
3360 3370 3380 3390 3400
ALSQALMGLS PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQRQLQQQ
3410 3420 3430 3440 3450
QQQQQQKVQQ QQQQQQQPKA SQTPVPQGPA SPDKDPAKES PKPEEQKNVP
3460 3470 3480 3490 3500
REVSPLLPKP PEEPEAESKS ASADSLCDPF IVPKVQYKLV CRKCQAGFGD
3510 3520 3530 3540 3550
EEAARSHLKS LCCFGQSVVN LQEMVLHVPT GSGGSGGGGG GSGGGGGSYH
3560 3570 3580 3590 3600
CLACESALCG EEALSQHLES ALHKHRTITR AARNAKEHPS LLPHSACFPD
3610 3620 3630 3640 3650
PSTASTSQSA AHSNDSPPPP SAAPSSSASP HASRKSWPPV GSRASAAKPP
3660 3670 3680 3690 3700
SFPPLSSSST VTSSSCSTSG VQPSMPTDDY SEESDTDLSQ KSDGPASPVE
3710 3720
GPKDPSCPKD SGLTSVGTDT FRL
Length:3,723
Mass (Da):406,106
Last modified:April 5, 2011 - v1
Checksum:i0098F351856FD5AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122873 Genomic DNA. No translation available.
AC127258 Genomic DNA. No translation available.
AC134561 Genomic DNA. No translation available.
RefSeqiNP_031522.2. NM_007496.2.
XP_006530648.1. XM_006530585.1.
UniGeneiMm.416972.
Mm.477670.

Genome annotation databases

EnsembliENSMUST00000043896; ENSMUSP00000044612; ENSMUSG00000038872.
GeneIDi11906.
KEGGimmu:11906.
UCSCiuc009nid.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122873 Genomic DNA. No translation available.
AC127258 Genomic DNA. No translation available.
AC134561 Genomic DNA. No translation available.
RefSeqi NP_031522.2. NM_007496.2.
XP_006530648.1. XM_006530585.1.
UniGenei Mm.416972.
Mm.477670.

3D structure databases

ProteinModelPortali E9QMD3.
SMRi E9QMD3. Positions 2153-2214, 2254-2312, 2645-2707, 3028-3073.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi E9QMD3.
PRIDEi E9QMD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043896 ; ENSMUSP00000044612 ; ENSMUSG00000038872 .
GeneIDi 11906.
KEGGi mmu:11906.
UCSCi uc009nid.1. mouse.

Organism-specific databases

CTDi 463.
MGIi MGI:99948. Zfhx3.

Phylogenomic databases

GeneTreei ENSGT00530000063717.
KOi K09378.
OMAi SVGMPPL.
OrthoDBi EOG7FR7FH.
TreeFami TF323288.

Miscellaneous databases

ChiTaRSi Zfhx3. mouse.
NextBioi 279957.
SOURCEi Search...

Gene expression databases

Bgeei E9QMD3.

Family and domain databases

Gene3Di 1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view ]
Pfami PF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 4 hits.
PROSITEi PS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QMD3_MOUSE
AccessioniPrimary (citable) accession number: E9QMD3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3