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Protein
Submitted name:

DNA repair protein-complementing XP-G cells homolog

Gene

Ercc5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. bubble DNA binding Source: MGI
  2. double-stranded DNA binding Source: MGI
  3. endodeoxyribonuclease activity Source: MGI
  4. protein homodimerization activity Source: MGI
  5. protein N-terminus binding Source: MGI
  6. single-stranded DNA binding Source: MGI

GO - Biological processi

  1. determination of adult lifespan Source: MGI
  2. DNA catabolic process, endonucleolytic Source: MGI
  3. DNA repair Source: MGI
  4. multicellular organism growth Source: MGI
  5. negative regulation of apoptotic process Source: MGI
  6. nucleotide-excision repair Source: MGI
  7. nucleotide-excision repair, DNA incision, 3'-to lesion Source: MGI
  8. response to UV Source: MGI
  9. response to UV-C Source: MGI
  10. transcription-coupled nucleotide-excision repair Source: MGI
  11. UV protection Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_279019. Dual incision reaction in TC-NER.
REACT_296832. Dual incision reaction in GG-NER.
REACT_302527. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_314261. Formation of incision complex in GG-NER.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA repair protein-complementing XP-G cells homologImported
Gene namesi
Name:Ercc5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103582. Ercc5.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament cytoskeleton Source: MGI
  2. nucleoplasm Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiE9QM61.

Expressioni

Gene expression databases

BgeeiE9QM61.
ExpressionAtlasiE9QM61. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9QM61.
SMRiE9QM61. Positions 2-113, 753-980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00640000091542.
KOiK10846.
OMAiFQATMRD.
OrthoDBiEOG72ZCD4.
TreeFamiTF101235.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF88723. SSF88723. 2 hits.
TIGRFAMsiTIGR00600. rad2. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QM61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQGLWKLL ECSGHRVSPE ALEGKVLAVD ISIWLNQALK GVRDSHGNVI
60 70 80 90 100
ENAHLLTLFH RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRQRKDSASI
110 120 130 140 150
DSRKTTEKLL KTFLKRQALK TAFRSSRHEA PPSLTQVQRQ DDIYVLPPLP
160 170 180 190 200
EEEKHSSEEE DEKQWQARMD QKQALQEEFF HNPQAIDIES EDFSSLPPEV
210 220 230 240 250
KHEILTDMKE FTKRRRTLFE AMPEESNDFS QYQLKGLLKK NYLNQHIENV
260 270 280 290 300
QKEMNQQHSG QIQRQYQDEG GFLKEVESRR VVSEDTSHYI LIKGIQGKKV
310 320 330 340 350
MDVDSESLPS SSNVHSVSSN LKSSPHEKVK PEREPEAAPP SPRTLLAIQA
360 370 380 390 400
AMLGSSSEDE PESREGRQSK ERNSGATADA GSISPRTCAA IQKALDDDND
410 420 430 440 450
EKVSGSSDDL AEKMLLGSGL EQEEHADETA ERGGGVPFDT APLTPSVTEV
460 470 480 490 500
KECVTSGSSA NGQTDSAHSF TTASHRCDTP KETVSLARAV KEASQISSEC
510 520 530 540 550
EVEGRPAALS PAFIGTPSSH VSGVLSEREP TLAPPTTRTH SDQGIDIHPE
560 570 580 590 600
DPELQNGLYP LETKCNSSRL SSDDETEGGQ NPAPKACSTV HVPAEAMSNL
610 620 630 640 650
ENALPSNAEE RGDFQETIQL REVPEAAARE LISAPKPMGP MEMESEESES
660 670 680 690 700
DGSFIEVQSV VSNSELQTES SEASTHLSEK DAEEPRETLE EGTSRDTECL
710 720 730 740 750
LQDSSDIEAM EGHREADIDA EDMPNEWQDI NLEELDALES NLLAEQNSLK
760 770 780 790 800
AQKQQQDRIA ASVTGQMFLE SQELLRLFGV PYIQAPMEAE AQCAMLDLTD
810 820 830 840 850
QTSGTITDDS DIWLFGARHV YKNFFNKNKF VEYYQYVDFY SQLGLDRNKL
860 870 880 890 900
INLAYLLGSD YTEGIPTVGC VTAMEILNEF PGRGLDPLLK FSEWWHEAQN
910 920 930 940 950
NKKVAENPYD TKVKKKLRKL QLTPGFPNPA VADAYLRPVV DDSRGSFLWG
960 970 980 990 1000
KPDVDKIREF CQRYFGWNRM KTDESLYPVL KHLNAHQTQL RIDSFFRLAQ
1010 1020 1030 1040 1050
QEKQDAKLIK SHRLNRAVTC ILRKEREEKA PELTKVTEAL DDAKGKTQKR
1060 1070 1080 1090 1100
ELPYKKETSV PKRRRPSGNG GFLGDPYCSE SPQESSCEDG EGSSVMSARQ
1110 1120 1130 1140 1150
RSAAESSKIS CSDVPDLVRD PPHGRQGCVS TSSSSEDDED KAKTVLVTAR
1160 1170
PVFGKKKLKL KSMKRRKKKT
Length:1,170
Mass (Da):130,812
Last modified:April 4, 2011 - v1
Checksum:iAEB8F387BE7690FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123800 Genomic DNA. No translation available.
RefSeqiNP_035859.2. NM_011729.2.
UniGeneiMm.2213.

Genome annotation databases

EnsembliENSMUST00000027214; ENSMUSP00000027214; ENSMUSG00000026048.
GeneIDi22592.
KEGGimmu:22592.
UCSCiuc007awi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123800 Genomic DNA. No translation available.
RefSeqiNP_035859.2. NM_011729.2.
UniGeneiMm.2213.

3D structure databases

ProteinModelPortaliE9QM61.
SMRiE9QM61. Positions 2-113, 753-980.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9QM61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027214; ENSMUSP00000027214; ENSMUSG00000026048.
GeneIDi22592.
KEGGimmu:22592.
UCSCiuc007awi.2. mouse.

Organism-specific databases

CTDi2073.
MGIiMGI:103582. Ercc5.

Phylogenomic databases

GeneTreeiENSGT00640000091542.
KOiK10846.
OMAiFQATMRD.
OrthoDBiEOG72ZCD4.
TreeFamiTF101235.

Enzyme and pathway databases

ReactomeiREACT_279019. Dual incision reaction in TC-NER.
REACT_296832. Dual incision reaction in GG-NER.
REACT_302527. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_314261. Formation of incision complex in GG-NER.

Miscellaneous databases

NextBioi302937.
SOURCEiSearch...

Gene expression databases

BgeeiE9QM61.
ExpressionAtlasiE9QM61. baseline and differential.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF88723. SSF88723. 2 hits.
TIGRFAMsiTIGR00600. rad2. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QM61_MOUSE
AccessioniPrimary (citable) accession number: E9QM61
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2011
Last sequence update: April 4, 2011
Last modified: March 31, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.