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E9QM61

- E9QM61_MOUSE

UniProt

E9QM61 - E9QM61_MOUSE

Protein
Submitted name:

DNA repair protein-complementing XP-G cells homolog

Gene

Ercc5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. endonuclease activity Source: InterPro
    2. single-stranded DNA binding Source: InterPro

    GO - Biological processi

    1. determination of adult lifespan Source: MGI
    2. DNA repair Source: MGI
    3. multicellular organism growth Source: MGI
    4. nucleotide-excision repair Source: MGI
    5. response to UV Source: MGI
    6. UV protection Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    DNA repair protein-complementing XP-G cells homologImported
    Gene namesi
    Name:Ercc5Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:103582. Ercc5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiE9QM61.

    Expressioni

    Gene expression databases

    ArrayExpressiE9QM61.
    BgeeiE9QM61.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QM61.
    SMRiE9QM61. Positions 2-127, 733-998.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00640000091542.
    KOiK10846.
    OMAiFQATMRD.
    OrthoDBiEOG72ZCD4.
    TreeFamiTF101235.

    Family and domain databases

    Gene3Di3.40.50.1010. 2 hits.
    InterProiIPR020045. 5-3_exonuclease_C.
    IPR008918. HhH2.
    IPR029060. PIN_domain-like.
    IPR006086. XPG-I_dom.
    IPR001044. XPG/Rad2_eukaryotes.
    IPR019974. XPG_CS.
    IPR006085. XPG_DNA_repair_N.
    [Graphical view]
    PfamiPF00867. XPG_I. 1 hit.
    PF00752. XPG_N. 1 hit.
    [Graphical view]
    PRINTSiPR00066. XRODRMPGMNTG.
    SMARTiSM00279. HhH2. 1 hit.
    SM00484. XPGI. 1 hit.
    SM00485. XPGN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47807. SSF47807. 1 hit.
    SSF88723. SSF88723. 2 hits.
    TIGRFAMsiTIGR00600. rad2. 1 hit.
    PROSITEiPS00841. XPG_1. 1 hit.
    PS00842. XPG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QM61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVQGLWKLL ECSGHRVSPE ALEGKVLAVD ISIWLNQALK GVRDSHGNVI     50
    ENAHLLTLFH RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRQRKDSASI 100
    DSRKTTEKLL KTFLKRQALK TAFRSSRHEA PPSLTQVQRQ DDIYVLPPLP 150
    EEEKHSSEEE DEKQWQARMD QKQALQEEFF HNPQAIDIES EDFSSLPPEV 200
    KHEILTDMKE FTKRRRTLFE AMPEESNDFS QYQLKGLLKK NYLNQHIENV 250
    QKEMNQQHSG QIQRQYQDEG GFLKEVESRR VVSEDTSHYI LIKGIQGKKV 300
    MDVDSESLPS SSNVHSVSSN LKSSPHEKVK PEREPEAAPP SPRTLLAIQA 350
    AMLGSSSEDE PESREGRQSK ERNSGATADA GSISPRTCAA IQKALDDDND 400
    EKVSGSSDDL AEKMLLGSGL EQEEHADETA ERGGGVPFDT APLTPSVTEV 450
    KECVTSGSSA NGQTDSAHSF TTASHRCDTP KETVSLARAV KEASQISSEC 500
    EVEGRPAALS PAFIGTPSSH VSGVLSEREP TLAPPTTRTH SDQGIDIHPE 550
    DPELQNGLYP LETKCNSSRL SSDDETEGGQ NPAPKACSTV HVPAEAMSNL 600
    ENALPSNAEE RGDFQETIQL REVPEAAARE LISAPKPMGP MEMESEESES 650
    DGSFIEVQSV VSNSELQTES SEASTHLSEK DAEEPRETLE EGTSRDTECL 700
    LQDSSDIEAM EGHREADIDA EDMPNEWQDI NLEELDALES NLLAEQNSLK 750
    AQKQQQDRIA ASVTGQMFLE SQELLRLFGV PYIQAPMEAE AQCAMLDLTD 800
    QTSGTITDDS DIWLFGARHV YKNFFNKNKF VEYYQYVDFY SQLGLDRNKL 850
    INLAYLLGSD YTEGIPTVGC VTAMEILNEF PGRGLDPLLK FSEWWHEAQN 900
    NKKVAENPYD TKVKKKLRKL QLTPGFPNPA VADAYLRPVV DDSRGSFLWG 950
    KPDVDKIREF CQRYFGWNRM KTDESLYPVL KHLNAHQTQL RIDSFFRLAQ 1000
    QEKQDAKLIK SHRLNRAVTC ILRKEREEKA PELTKVTEAL DDAKGKTQKR 1050
    ELPYKKETSV PKRRRPSGNG GFLGDPYCSE SPQESSCEDG EGSSVMSARQ 1100
    RSAAESSKIS CSDVPDLVRD PPHGRQGCVS TSSSSEDDED KAKTVLVTAR 1150
    PVFGKKKLKL KSMKRRKKKT 1170
    Length:1,170
    Mass (Da):130,812
    Last modified:April 5, 2011 - v1
    Checksum:iAEB8F387BE7690FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123800 Genomic DNA. No translation available.
    RefSeqiNP_035859.2. NM_011729.2.
    UniGeneiMm.2213.

    Genome annotation databases

    EnsembliENSMUST00000027214; ENSMUSP00000027214; ENSMUSG00000026048.
    GeneIDi22592.
    KEGGimmu:22592.
    UCSCiuc007awi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123800 Genomic DNA. No translation available.
    RefSeqi NP_035859.2. NM_011729.2.
    UniGenei Mm.2213.

    3D structure databases

    ProteinModelPortali E9QM61.
    SMRi E9QM61. Positions 2-127, 733-998.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9QM61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027214 ; ENSMUSP00000027214 ; ENSMUSG00000026048 .
    GeneIDi 22592.
    KEGGi mmu:22592.
    UCSCi uc007awi.2. mouse.

    Organism-specific databases

    CTDi 2073.
    MGIi MGI:103582. Ercc5.

    Phylogenomic databases

    GeneTreei ENSGT00640000091542.
    KOi K10846.
    OMAi FQATMRD.
    OrthoDBi EOG72ZCD4.
    TreeFami TF101235.

    Enzyme and pathway databases

    Reactomei REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.

    Miscellaneous databases

    NextBioi 302937.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9QM61.
    Bgeei E9QM61.

    Family and domain databases

    Gene3Di 3.40.50.1010. 2 hits.
    InterProi IPR020045. 5-3_exonuclease_C.
    IPR008918. HhH2.
    IPR029060. PIN_domain-like.
    IPR006086. XPG-I_dom.
    IPR001044. XPG/Rad2_eukaryotes.
    IPR019974. XPG_CS.
    IPR006085. XPG_DNA_repair_N.
    [Graphical view ]
    Pfami PF00867. XPG_I. 1 hit.
    PF00752. XPG_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00066. XRODRMPGMNTG.
    SMARTi SM00279. HhH2. 1 hit.
    SM00484. XPGI. 1 hit.
    SM00485. XPGN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47807. SSF47807. 1 hit.
    SSF88723. SSF88723. 2 hits.
    TIGRFAMsi TIGR00600. rad2. 1 hit.
    PROSITEi PS00841. XPG_1. 1 hit.
    PS00842. XPG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QM61_MOUSE
    AccessioniPrimary (citable) accession number: E9QM61
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3