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E9QM61

- E9QM61_MOUSE

UniProt

E9QM61 - E9QM61_MOUSE

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Protein
Submitted name: DNA repair protein-complementing XP-G cells homolog
Gene
Ercc5
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. endonuclease activity Source: InterPro
  2. single-stranded DNA binding Source: InterPro

GO - Biological processi

  1. DNA repair Source: MGI
  2. UV protection Source: MGI
  3. determination of adult lifespan Source: MGI
  4. multicellular organism growth Source: MGI
  5. nucleotide-excision repair Source: MGI
  6. response to UV Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA repair protein-complementing XP-G cells homologImported
Gene namesi
Name:Ercc5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:103582. Ercc5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiE9QM61.

Expressioni

Gene expression databases

ArrayExpressiE9QM61.
BgeeiE9QM61.

Structurei

3D structure databases

ProteinModelPortaliE9QM61.
SMRiE9QM61. Positions 2-127, 733-998.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00640000091542.
KOiK10846.
OMAiFQATMRD.
OrthoDBiEOG72ZCD4.
TreeFamiTF101235.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF88723. SSF88723. 2 hits.
TIGRFAMsiTIGR00600. rad2. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QM61-1 [UniParc]FASTAAdd to Basket

« Hide

MGVQGLWKLL ECSGHRVSPE ALEGKVLAVD ISIWLNQALK GVRDSHGNVI     50
ENAHLLTLFH RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRQRKDSASI 100
DSRKTTEKLL KTFLKRQALK TAFRSSRHEA PPSLTQVQRQ DDIYVLPPLP 150
EEEKHSSEEE DEKQWQARMD QKQALQEEFF HNPQAIDIES EDFSSLPPEV 200
KHEILTDMKE FTKRRRTLFE AMPEESNDFS QYQLKGLLKK NYLNQHIENV 250
QKEMNQQHSG QIQRQYQDEG GFLKEVESRR VVSEDTSHYI LIKGIQGKKV 300
MDVDSESLPS SSNVHSVSSN LKSSPHEKVK PEREPEAAPP SPRTLLAIQA 350
AMLGSSSEDE PESREGRQSK ERNSGATADA GSISPRTCAA IQKALDDDND 400
EKVSGSSDDL AEKMLLGSGL EQEEHADETA ERGGGVPFDT APLTPSVTEV 450
KECVTSGSSA NGQTDSAHSF TTASHRCDTP KETVSLARAV KEASQISSEC 500
EVEGRPAALS PAFIGTPSSH VSGVLSEREP TLAPPTTRTH SDQGIDIHPE 550
DPELQNGLYP LETKCNSSRL SSDDETEGGQ NPAPKACSTV HVPAEAMSNL 600
ENALPSNAEE RGDFQETIQL REVPEAAARE LISAPKPMGP MEMESEESES 650
DGSFIEVQSV VSNSELQTES SEASTHLSEK DAEEPRETLE EGTSRDTECL 700
LQDSSDIEAM EGHREADIDA EDMPNEWQDI NLEELDALES NLLAEQNSLK 750
AQKQQQDRIA ASVTGQMFLE SQELLRLFGV PYIQAPMEAE AQCAMLDLTD 800
QTSGTITDDS DIWLFGARHV YKNFFNKNKF VEYYQYVDFY SQLGLDRNKL 850
INLAYLLGSD YTEGIPTVGC VTAMEILNEF PGRGLDPLLK FSEWWHEAQN 900
NKKVAENPYD TKVKKKLRKL QLTPGFPNPA VADAYLRPVV DDSRGSFLWG 950
KPDVDKIREF CQRYFGWNRM KTDESLYPVL KHLNAHQTQL RIDSFFRLAQ 1000
QEKQDAKLIK SHRLNRAVTC ILRKEREEKA PELTKVTEAL DDAKGKTQKR 1050
ELPYKKETSV PKRRRPSGNG GFLGDPYCSE SPQESSCEDG EGSSVMSARQ 1100
RSAAESSKIS CSDVPDLVRD PPHGRQGCVS TSSSSEDDED KAKTVLVTAR 1150
PVFGKKKLKL KSMKRRKKKT 1170
Length:1,170
Mass (Da):130,812
Last modified:April 5, 2011 - v1
Checksum:iAEB8F387BE7690FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123800 Genomic DNA. No translation available.
RefSeqiNP_035859.2. NM_011729.2.
UniGeneiMm.2213.

Genome annotation databases

EnsembliENSMUST00000027214; ENSMUSP00000027214; ENSMUSG00000026048.
GeneIDi22592.
KEGGimmu:22592.
UCSCiuc007awi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123800 Genomic DNA. No translation available.
RefSeqi NP_035859.2. NM_011729.2.
UniGenei Mm.2213.

3D structure databases

ProteinModelPortali E9QM61.
SMRi E9QM61. Positions 2-127, 733-998.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9QM61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027214 ; ENSMUSP00000027214 ; ENSMUSG00000026048 .
GeneIDi 22592.
KEGGi mmu:22592.
UCSCi uc007awi.2. mouse.

Organism-specific databases

CTDi 2073.
MGIi MGI:103582. Ercc5.

Phylogenomic databases

GeneTreei ENSGT00640000091542.
KOi K10846.
OMAi FQATMRD.
OrthoDBi EOG72ZCD4.
TreeFami TF101235.

Enzyme and pathway databases

Reactomei REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.

Miscellaneous databases

NextBioi 302937.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9QM61.
Bgeei E9QM61.

Family and domain databases

Gene3Di 3.40.50.1010. 2 hits.
InterProi IPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view ]
Pfami PF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view ]
PRINTSi PR00066. XRODRMPGMNTG.
SMARTi SM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view ]
SUPFAMi SSF47807. SSF47807. 1 hit.
SSF88723. SSF88723. 2 hits.
TIGRFAMsi TIGR00600. rad2. 1 hit.
PROSITEi PS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QM61_MOUSE
AccessioniPrimary (citable) accession number: E9QM61
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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