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Protein
Submitted name:

Potassium voltage gated channel, Shaw-related subfamily, member 2, isoform CRA_a

Gene

Kcnc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage gated channel, Shaw-related subfamily, member 2, isoform CRA_aImported
Submitted name:
Potassium voltage-gated channel subfamily C member 2Imported
Gene namesi
Name:Kcnc2Imported
ORF Names:mCG_142089Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96668. Kcnc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei231 – 250HelicalSequence analysisAdd BLAST20
Transmembranei285 – 307HelicalSequence analysisAdd BLAST23
Transmembranei314 – 332HelicalSequence analysisAdd BLAST19
Transmembranei386 – 407HelicalSequence analysisAdd BLAST22
Transmembranei428 – 445HelicalSequence analysisAdd BLAST18
Transmembranei457 – 486HelicalSequence analysisAdd BLAST30

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiE9QLW0.
PeptideAtlasiE9QLW0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035681.
GenevisibleiE9QLW0. MM.

Structurei

3D structure databases

ProteinModelPortaliE9QLW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 163BTB (POZ)InterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
KOiK04888.
OMAiHYAHAAM.
OrthoDBiEOG091G0EJL.
TreeFamiTF352511.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PRINTSiPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 2 hits.

Sequencei

Sequence statusi: Complete.

E9QLW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIESNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPQGDCLTAA
60 70 80 90 100
GDKLQPLPPP LSPPPRPPPL SPVPSGCFEG GAGNCSSHGG NGGNGGSDHP
110 120 130 140 150
GGGREFFFDR HPGVFAYVLN YYRTGKLHCP ADVCGPLFEE ELAFWGIDET
160 170 180 190 200
DVEPCCWMTY RQHRDAEEAL DIFETPDLIG GDPGDDEDLA AKRLGIEDAA
210 220 230 240 250
GLGGPDGKSG RWRKLQPRMW ALFEDPYSSR AARFIAFASL FFILVSITTF
260 270 280 290 300
CLETHEAFNI VKNKTEPVIN GTSPVLQYEI ETDPALTYVE GVCVVWFTFE
310 320 330 340 350
FLVRIVFSPN KLEFIKNLLN IIDFVAILPF YLEVGLSGLS SKAAKDVLGF
360 370 380 390 400
LRVVRFVRIL RIFKLTRHFV GLRVLGHTLR ASTNEFLLLI IFLALGVLIF
410 420 430 440 450
ATMIYYAERV GAQPNDPSAS EHTQFKNIPI GFWWAVVTMT TLGYGDMYPQ
460 470 480 490 500
TWSGMLVGAL CALAGVLTIA MPVPVIVNNF GMYYSLAMAK QKLPRKRKKH
510 520 530 540 550
IPPAPLASSP TFCKTELNMA CNSTQSDTCL GKENRLLEHN RSVLSGDDST
560 570 580 590 600
GSEPPLSPPE RLPIRRSSTR DKNRRGETCF LLTTGDYTCA SDGGIRKGYE
610 620 630 640
KSRSLNNIAG LAGNALRLSP VTSPYNSPCP LRRSRSPIPS IL
Length:642
Mass (Da):70,503
Last modified:June 7, 2017 - v2
Checksum:i2B9B6D29A40A80E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121610 Genomic DNA. No translation available.
AC153500 Genomic DNA. No translation available.
CH466539 Genomic DNA. Translation: EDL21751.1.
CH466539 Genomic DNA. Translation: EDL21756.1.
RefSeqiXP_006513748.1. XM_006513685.3.
XP_006513750.1. XM_006513687.3.
XP_006513751.1. XM_006513688.1.
XP_006513752.1. XM_006513689.3.
XP_006513753.1. XM_006513690.2.
UniGeneiMm.336242.

Genome annotation databases

EnsembliENSMUST00000092175; ENSMUSP00000089814; ENSMUSG00000035681.
GeneIDi268345.
KEGGimmu:268345.
UCSCiuc007hap.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE9QLW0_MOUSE
AccessioniPrimary (citable) accession number: E9QLW0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: June 7, 2017
Last modified: July 5, 2017
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported