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Protein
Submitted name:

Potassium voltage gated channel, Shaw-related subfamily, member 2, isoform CRA_a

Gene

Kcnc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage gated channel, Shaw-related subfamily, member 2, isoform CRA_aImported
Submitted name:
Potassium voltage-gated channel subfamily C member 2Imported
Gene namesi
Name:Kcnc2Imported
ORF Names:mCG_142089Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96668 Kcnc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei231 – 250HelicalSequence analysisAdd BLAST20
Transmembranei285 – 307HelicalSequence analysisAdd BLAST23
Transmembranei314 – 332HelicalSequence analysisAdd BLAST19
Transmembranei386 – 407HelicalSequence analysisAdd BLAST22
Transmembranei428 – 445HelicalSequence analysisAdd BLAST18
Transmembranei457 – 486HelicalSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000035681
GenevisibleiE9QLW0 MM

Structurei

3D structure databases

ProteinModelPortaliE9QLW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 163BTBInterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
OrthoDBiEOG091G0EJL
TreeFamiTF352511

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003974 K_chnl_volt-dep_Kv3
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01491 KVCHANNEL
PR01498 SHAWCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 2 hits

Sequencei

Sequence statusi: Complete.

E9QLW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIESNERV ILNVGGTRHE TYRSTLKTLP GTRLALLASS EPQGDCLTAA
60 70 80 90 100
GDKLQPLPPP LSPPPRPPPL SPVPSGCFEG GAGNCSSHGG NGGNGGSDHP
110 120 130 140 150
GGGREFFFDR HPGVFAYVLN YYRTGKLHCP ADVCGPLFEE ELAFWGIDET
160 170 180 190 200
DVEPCCWMTY RQHRDAEEAL DIFETPDLIG GDPGDDEDLA AKRLGIEDAA
210 220 230 240 250
GLGGPDGKSG RWRKLQPRMW ALFEDPYSSR AARFIAFASL FFILVSITTF
260 270 280 290 300
CLETHEAFNI VKNKTEPVIN GTSPVLQYEI ETDPALTYVE GVCVVWFTFE
310 320 330 340 350
FLVRIVFSPN KLEFIKNLLN IIDFVAILPF YLEVGLSGLS SKAAKDVLGF
360 370 380 390 400
LRVVRFVRIL RIFKLTRHFV GLRVLGHTLR ASTNEFLLLI IFLALGVLIF
410 420 430 440 450
ATMIYYAERV GAQPNDPSAS EHTQFKNIPI GFWWAVVTMT TLGYGDMYPQ
460 470 480 490 500
TWSGMLVGAL CALAGVLTIA MPVPVIVNNF GMYYSLAMAK QKLPRKRKKH
510 520 530 540 550
IPPAPLASSP TFCKTELNMA CNSTQSDTCL GKENRLLEHN RSVLSGDDST
560 570 580 590 600
GSEPPLSPPE RLPIRRSSTR DKNRRGETCF LLTTGDYTCA SDGGIRKGYE
610 620 630 640
KSRSLNNIAG LAGNALRLSP VTSPYNSPCP LRRSRSPIPS IL
Length:642
Mass (Da):70,503
Last modified:June 7, 2017 - v2
Checksum:i2B9B6D29A40A80E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121610 Genomic DNA No translation available.
AC153500 Genomic DNA No translation available.
CH466539 Genomic DNA Translation: EDL21751.1
CH466539 Genomic DNA Translation: EDL21756.1
RefSeqiXP_006513748.1, XM_006513685.3
XP_006513750.1, XM_006513687.3
XP_006513751.1, XM_006513688.1
XP_006513752.1, XM_006513689.3
XP_006513753.1, XM_006513690.2
UniGeneiMm.336242

Genome annotation databases

EnsembliENSMUST00000092175; ENSMUSP00000089814; ENSMUSG00000035681
GeneIDi268345
UCSCiuc007hap.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QLW0_MOUSE
AccessioniPrimary (citable) accession number: E9QLW0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: June 7, 2017
Last modified: March 28, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health