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Protein
Submitted name:

Transformation/transcription domain-associated protein

Gene

Trrap

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.

Names & Taxonomyi

Protein namesi
Submitted name:
Transformation/transcription domain-associated proteinImported
Gene namesi
Name:TrrapImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2153272. Trrap.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9QLK7.
PaxDbiE9QLK7.
PRIDEiE9QLK7.

Expressioni

Gene expression databases

BgeeiE9QLK7.
ExpressionAtlasiE9QLK7. baseline and differential.
GenevisibleiE9QLK7. MM.

Interactioni

Protein-protein interaction databases

IntActiE9QLK7. 3 interactions.
STRINGi10090.ENSMUSP00000098035.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2685 – 3245561FATInterPro annotationAdd
BLAST
Domaini3516 – 3727212PI3K/PI4KInterPro annotationAdd
BLAST
Domaini3815 – 384733FATCInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2767 – 279125Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation
Contains FAT domain.SAAS annotation
Contains FATC domain.SAAS annotation
Contains PI3K/PI4K domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0889. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00390000017961.
KOiK08874.
OrthoDBiEOG7VHSW8.
TreeFamiTF106414.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.10.10. 5 hits.
1.25.40.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical_dom.
IPR033317. TRA1/TRRAP.
[Graphical view]
PANTHERiPTHR11139:SF1. PTHR11139:SF1. 6 hits.
PfamiPF02259. FAT. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 13 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QLK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE
60 70 80 90 100
NVTSSPQYST FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEILHRI
110 120 130 140 150
PTNEHLRPHT KNVLSVMFRF LETENEENVL ICLRIIIELH KQFRPPITQE
160 170 180 190 200
IHHFLDFVKQ IYKELPKVVN RYFENPQGIP ENTVPPPEMV GMITTVAVKV
210 220 230 240 250
NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK LNIHNVVAEF
260 270 280 290 300
VPLIMNTIAI QVSTQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE
310 320 330 340 350
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC
360 370 380 390 400
MDKLFDESIL IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ
410 420 430 440 450
LFAKNIDDES LPSSIQTMSC KLLLNLVDCI RSKSEQESGN GRDVLMRMLE
460 470 480 490 500
VFVLKFHTIA RYQLSAIFKK CKPQSELGAA EAALPGVPTA PAAPGPAPSP
510 520 530 540 550
APVPAPAPPP PPPPAPATPV TPAPVPPFEK QGEKDKEDKQ TFQVTDCRSL
560 570 580 590 600
VKTLVCGVKT ITWGITSCKA PGAQFIPNKQ LQPKETQIYI KLVKYAMQAL
610 620 630 640 650
DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI
660 670 680 690 700
FQTTVPYMVE RISKNYALQI VANSFLANPT TSALFATILV EYLLERLPEM
710 720 730 740 750
GSNVELSNLY LKLFKLVFGS VSLFAAENEQ MLKPHLHKIV NSSMELAQTA
760 770 780 790 800
KEPYNYFLLL RALFRSIGGG SHDLLYQEFL PLLPNLLQGL NMLQSGLHKQ
810 820 830 840 850
HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT LVSQGLRTLE
860 870 880 890 900
LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG
910 920 930 940 950
SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL
960 970 980 990 1000
KSANTEPYYR RQAWEVIRCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN
1010 1020 1030 1040 1050
VIISHRYKAQ DTPARKTFEQ ALTGAFMSAV IKDLRPSALP FVASLIRHYT
1060 1070 1080 1090 1100
MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE ENGSKGMDPL VLIDAIAICM
1110 1120 1130 1140 1150
AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY IVERLCACCY
1160 1170 1180 1190 1200
EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN
1210 1220 1230 1240 1250
GAVAMAKTTL EQLLMRCATP LKDEERAEEI VLAQEKSFHH VTHDLVREVT
1260 1270 1280 1290 1300
SPNSTVRKQA MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ
1310 1320 1330 1340 1350
PANAQIGLME GNTFCTTLQP RLFTMDLNVV EHKVFYTELL NLCEAEDSAL
1360 1370 1380 1390 1400
TKLPCYKSLP SLVPLRIAAL NALAACNYLP QSREKIIAAL FKALNSTNSE
1410 1420 1430 1440 1450
LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL TLNVVNRLTS
1460 1470 1480 1490 1500
VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NEMKICSAII
1510 1520 1530 1540 1550
NLFHLIPAAP QTLVKPLLEV VMKTERAMLI EAGSPFREPL IKFLTRHPSQ
1560 1570 1580 1590 1600
TVELFMMEAT LNDPQWSRMF MSFLKHKDAR PLRDVLAANP NRFITLLLPG
1610 1620 1630 1640 1650
GAQTAVRPGS PSTSNMRLDL QFQAIKIISI IVKNDDAWLA SQHSLVSQLR
1660 1670 1680 1690 1700
RVWVSETFQE RHRKENMAAT NWKEPKLLAF CLLNYCKRNY GDIELLFQLL
1710 1720 1730 1740 1750
RAFTGRFLCN MTFLKEYMEE EIPKNYSIAQ KRALFFRFVE FNDPNFGDEL
1760 1770 1780 1790 1800
KAKVLQHILN PAFLYSFEKG EGEQLLGPPN PEGDNPESIT SVFITKVLDP
1810 1820 1830 1840 1850
EKQADMLDSL RIYLLQYATL LVEHAPHHIH DNNKNRNSKL RRLMTFAWPC
1860 1870 1880 1890 1900
LLSKACVDPA CKYSGHLLLA HIIAKFAIHK KIVLQVFHSL LKAHAMEARA
1910 1920 1930 1940 1950
IVRQAMAILT PAVPARMEDG HQMLTHWTRK IIVEEGHTVP QLVHILHLIV
1960 1970 1980 1990 2000
QHFKVYYPVR HHLVQHMVSA MQRLGFTPSV TIEQRRLAVD LSEVVIKWEL
2010 2020 2030 2040 2050
QRIKDQQPDS DMDPNSSGEG VNSVSIKRGL SVDSAQEVKR FRAATGAISA
2060 2070 2080 2090 2100
VFGRSQSLPG ADSLLAKPID KQHTDTVVNF LIRVACQVND NTNTAGSPGE
2110 2120 2130 2140 2150
VLSRRCVNLL KTALRPDMWC KSELKLQWFD KLLMTVEQPN QVNYGNICTG
2160 2170 2180 2190 2200
LEVLNFLLTV LQSPAILSSF KPLQRGIAAC MTCGNTKVLR AVHSLLSRLM
2210 2220 2230 2240 2250
SIFPTEPSTS SVASKYEELE CLYAAVGKVI YEGLTNYEKA TSANPSQLFG
2260 2270 2280 2290 2300
TLMILKSACC NNPSYIDRLI SVFMRSLQKM VREHLNPQTA SGSTEATAAG
2310 2320 2330 2340 2350
TSELVMLSLD LVKTRLAVMS MEMRKNFIQT ILTSLIEKSP DAKILRAVVK
2360 2370 2380 2390 2400
IVEEWVKNNS PMAANQTPTL REKSILLVKM MTYIEKRFPE DLELNAQFLD
2410 2420 2430 2440 2450
LVNYVYRDEA LSGSELTAKL EPAFLSGLRC AQPLIRAKFF EVFDNSMKRR
2460 2470 2480 2490 2500
VYERLLYVTC SQNWEAMGSH FWIKQCIELL LAVCEKSTAI GTSCQGAMLP
2510 2520 2530 2540 2550
SITNVINLAD SHDRAAFAMV THVKQEPRER ENSESKEEDV EIDIELAPGD
2560 2570 2580 2590 2600
QTSTPKTKEL SEKDIGNQLH MLTNRHDKFL DTLREVKTGA LLSAFVQLCH
2610 2620 2630 2640 2650
ISTTLAEKTW VQLFPRLWKI LSDRQQHALA GEISPFLCSG SHQVQRDCQP
2660 2670 2680 2690 2700
SALNCFVEAM SQCVPPIPMR PCVLKYLGKT HNLWFRSTLM LEHQAFEKGL
2710 2720 2730 2740 2750
SLPIKPKQTT EFYEQESITP PQQEILDSLA ELYSLLQEED MWAGLWQKRC
2760 2770 2780 2790 2800
KFSETATAIA YEQHGFFEQA QESYEKAMDK AKKEHERSNA SPAIFPEYQL
2810 2820 2830 2840 2850
WEDHWIRCSK ELNQWEALTE FGQSKGHINP YLVLECAWRV SNWTAMKEAL
2860 2870 2880 2890 2900
VQVEVSCPKE MAWKVNMYRG YLAICHPEEQ QLSFIERLVE MASSLAIREW
2910 2920 2930 2940 2950
RRLPHVVSHV HTPLLQAAQQ IIELQEAAQI NAGLQPTNLG RNNSLHDMKT
2960 2970 2980 2990 3000
VVKTWRNRLP IVSDDLSHWS SVFMWRQHHY QAIVTAYENS SHHDPSSNNA
3010 3020 3030 3040 3050
MLGVHASASA IIQYGKIARK QGLVNVALDI LSRIHTIPTV PIVDCFQKIR
3060 3070 3080 3090 3100
QQVKCYLQLA GVMGKNECMQ GLEVIESTNL KYFTKEMTAE FYALKGMFLA
3110 3120 3130 3140 3150
QINKSEEANK AFSAAVQMHD VLVKAWAMWG DYLESIFVKE RQLHLGVSAI
3160 3170 3180 3190 3200
TCYLHACRHQ NESKSRKYLA KVLWLLSFDD DKNTLADAVD KYCIGVPPIQ
3210 3220 3230 3240 3250
WLAWIPQLLT CLVGSEGKLL LNLISQVGRV YPQAVYFPIR TLYLTLKIEQ
3260 3270 3280 3290 3300
RERYKSDSGQ QQPSSAGNQS HSASDPGPIR ATAPMWRCSR IMHMQRELHP
3310 3320 3330 3340 3350
TLLSSLEGIV DQMVWFRENW HEEVLRQLQQ GLAKCYSVAF EKSGAVSDAK
3360 3370 3380 3390 3400
ITPHTLNFVK KLVSTFGVGL ENVSNVSTMF SSAASESLAR RAQATAQDPV
3410 3420 3430 3440 3450
FQKLKGQFTT DFDFSVPGSM KLHNLISKLK KWIKILEAKT KQLPKFFLIE
3460 3470 3480 3490 3500
EKCRFLSNFS AQTAEVEIPG EFLMPKPTHY YIKIARFMPR VEIVQKHNTA
3510 3520 3530 3540 3550
ARRLHIRGHN GKIYPYLVMN DACLTESRRE ERVLQLLRLL NPCLEKRKET
3560 3570 3580 3590 3600
TKRHLFFTVP RVVAVSPQMR LVEDNPSSLS LVEIYKQRCA KKGIEHDNPI
3610 3620 3630 3640 3650
SRYYDRLATV QARGTQASHQ VLRDILKEVQ SNMVPRSMLK EWALHTFPNA
3660 3670 3680 3690 3700
TDYWTFRKMF TIQLALIGFA EFVLHLNRLN PEMLQIAQDT GKLNVAYFRF
3710 3720 3730 3740 3750
DINDATGDLD ANRPVPFRLT PNISEFLTTI GVSGPLTASM IAVARCFAQP
3760 3770 3780 3790 3800
NFKVDGVLKT VLRDEIIAWH KKTQEDTSSP LSAAGQPENM DSQQLVSLVQ
3810 3820 3830 3840
KAVTAIMTRL HNLAQFDGGE SKVNTLVAAA NSLDNLCRMD PAWHPWL
Length:3,847
Mass (Da):435,801
Last modified:April 5, 2011 - v1
Checksum:iF7C915CC796F8BFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113295 Genomic DNA. No translation available.
AC131728 Genomic DNA. No translation available.
RefSeqiNP_001074831.1. NM_001081362.1.
UniGeneiMm.273570.

Genome annotation databases

EnsembliENSMUST00000100467; ENSMUSP00000098035; ENSMUSG00000045482.
GeneIDi100683.
KEGGimmu:100683.
UCSCiuc009alt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113295 Genomic DNA. No translation available.
AC131728 Genomic DNA. No translation available.
RefSeqiNP_001074831.1. NM_001081362.1.
UniGeneiMm.273570.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9QLK7. 3 interactions.
STRINGi10090.ENSMUSP00000098035.

Proteomic databases

MaxQBiE9QLK7.
PaxDbiE9QLK7.
PRIDEiE9QLK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100467; ENSMUSP00000098035; ENSMUSG00000045482.
GeneIDi100683.
KEGGimmu:100683.
UCSCiuc009alt.1. mouse.

Organism-specific databases

CTDi8295.
MGIiMGI:2153272. Trrap.

Phylogenomic databases

eggNOGiKOG0889. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00390000017961.
KOiK08874.
OrthoDBiEOG7VHSW8.
TreeFamiTF106414.

Enzyme and pathway databases

ReactomeiR-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.

Miscellaneous databases

NextBioi354584.
SOURCEiSearch...

Gene expression databases

BgeeiE9QLK7.
ExpressionAtlasiE9QLK7. baseline and differential.
GenevisibleiE9QLK7. MM.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.10.10. 5 hits.
1.25.40.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical_dom.
IPR033317. TRA1/TRRAP.
[Graphical view]
PANTHERiPTHR11139:SF1. PTHR11139:SF1. 6 hits.
PfamiPF02259. FAT. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 13 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QLK7_MOUSE
AccessioniPrimary (citable) accession number: E9QLK7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.