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Protein
Submitted name:

Microphthalmia-associated transcription factor

Gene

Mitf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Microphthalmia-associated transcription factorImported
Gene namesi
Name:MitfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104554. Mitf.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

MaxQBiE9QL92.
PaxDbiE9QL92.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035158.
ExpressionAtlasiE9QL92. baseline and differential.
GenevisibleiE9QL92. MM.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9QL92.
SMRiE9QL92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 348BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 72Sequence analysisAdd BLAST29
Coiled coili341 – 382Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR021802. MiT/TFE_C.
IPR031867. MiT/TFE_N.
IPR030532. MITF.
PANTHERiPTHR12565:SF258. PTHR12565:SF258. 1 hit.
PfamiView protein in Pfam
PF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
PF15951. MITF_TFEB_C_3_N. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

E9QL92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALRFEMLI PCSFESLCLS SAEHSGASKP PLSSSTMTSR ILLRQQLMRE
60 70 80 90 100
QMQEQERREQ QQKLQAAQFM QQRVAVSQTP AINVSVPTTL PSATQVPMEV
110 120 130 140 150
LKVQTHLENP TKYHIQQAQR HQVKQYLSTT LANKHASQVL SSPCPNQPGD
160 170 180 190 200
HAMPPVPGSS APNSPMAMLT LNSNCEKEAF YKFEEQSRAE SECPGMNTHS
210 220 230 240 250
RASCMQMDDV IDDIISLESS YNEEILGLMD PALQMANTLP VSGNLIDLYS
260 270 280 290 300
NQGLPPPGLT ISNSCPANLP NIKRELTACI FPTESEARAL AKERQKKDNH
310 320 330 340 350
NLIERRRRFN INDRIKELGT LIPKSNDPDM RWNKGTILKA SVDYIRKLQR
360 370 380 390 400
EQQRAKDLEN RQKKLEHANR HLLLRVQELE MQARAHGLSL IPSTGLCSPD
410 420 430 440 450
LVNRIIKQEP VLENCSQELV QHQADLTCTT TLDLTDGTIT FTNNLGTMPE
460 470 480 490 500
SSPAYSIPRK MGSNLEDILM DDALSPVGVT DPLLSSVSPG ASKTSSRRSS
510
MSAEETEHAC
Length:510
Mass (Da):56,818
Last modified:April 5, 2011 - v1
Checksum:i47CD5802DDA9686D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131676 Genomic DNA. No translation available.
AC157098 Genomic DNA. No translation available.
AC158650 Genomic DNA. No translation available.
RefSeqiNP_001171520.1. NM_001178049.1.
UniGeneiMm.333284.
Mm.454504.

Genome annotation databases

EnsembliENSMUST00000101123; ENSMUSP00000098683; ENSMUSG00000035158.
GeneIDi17342.
UCSCiuc009dba.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE9QL92_MOUSE
AccessioniPrimary (citable) accession number: E9QL92
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 5, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported