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Protein
Submitted name:

Microphthalmia-associated transcription factor

Gene

Mitf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-3232118. SUMOylation of transcription factors.

Names & Taxonomyi

Protein namesi
Submitted name:
Microphthalmia-associated transcription factorImported
Gene namesi
Name:MitfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104554. Mitf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiE9QL92.

Expressioni

Gene expression databases

BgeeiE9QL92.
ExpressionAtlasiE9QL92. baseline and differential.
GenevisibleiE9QL92. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044938.

Structurei

3D structure databases

ProteinModelPortaliE9QL92.
SMRiE9QL92. Positions 308-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 34854BHLH (basic helix-loop-helix)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili44 – 7229Sequence analysisAdd
BLAST
Coiled coili341 – 38242Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR021802. MiT/TFE_C.
IPR031867. MiT/TFE_N.
IPR030532. MITF.
[Graphical view]
PANTHERiPTHR12565:SF91. PTHR12565:SF91. 2 hits.
PfamiPF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
PF15951. MITF_TFEB_C_3_N. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QL92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALRFEMLI PCSFESLCLS SAEHSGASKP PLSSSTMTSR ILLRQQLMRE
60 70 80 90 100
QMQEQERREQ QQKLQAAQFM QQRVAVSQTP AINVSVPTTL PSATQVPMEV
110 120 130 140 150
LKVQTHLENP TKYHIQQAQR HQVKQYLSTT LANKHASQVL SSPCPNQPGD
160 170 180 190 200
HAMPPVPGSS APNSPMAMLT LNSNCEKEAF YKFEEQSRAE SECPGMNTHS
210 220 230 240 250
RASCMQMDDV IDDIISLESS YNEEILGLMD PALQMANTLP VSGNLIDLYS
260 270 280 290 300
NQGLPPPGLT ISNSCPANLP NIKRELTACI FPTESEARAL AKERQKKDNH
310 320 330 340 350
NLIERRRRFN INDRIKELGT LIPKSNDPDM RWNKGTILKA SVDYIRKLQR
360 370 380 390 400
EQQRAKDLEN RQKKLEHANR HLLLRVQELE MQARAHGLSL IPSTGLCSPD
410 420 430 440 450
LVNRIIKQEP VLENCSQELV QHQADLTCTT TLDLTDGTIT FTNNLGTMPE
460 470 480 490 500
SSPAYSIPRK MGSNLEDILM DDALSPVGVT DPLLSSVSPG ASKTSSRRSS
510
MSAEETEHAC
Length:510
Mass (Da):56,818
Last modified:April 5, 2011 - v1
Checksum:i47CD5802DDA9686D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131676 Genomic DNA. No translation available.
AC157098 Genomic DNA. No translation available.
AC158650 Genomic DNA. No translation available.
RefSeqiNP_001171520.1. NM_001178049.1.
UniGeneiMm.333284.
Mm.454504.

Genome annotation databases

EnsembliENSMUST00000101123; ENSMUSP00000098683; ENSMUSG00000035158.
GeneIDi17342.
UCSCiuc009dba.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131676 Genomic DNA. No translation available.
AC157098 Genomic DNA. No translation available.
AC158650 Genomic DNA. No translation available.
RefSeqiNP_001171520.1. NM_001178049.1.
UniGeneiMm.333284.
Mm.454504.

3D structure databases

ProteinModelPortaliE9QL92.
SMRiE9QL92. Positions 308-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044938.

Proteomic databases

PaxDbiE9QL92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101123; ENSMUSP00000098683; ENSMUSG00000035158.
GeneIDi17342.
UCSCiuc009dba.2. mouse.

Organism-specific databases

CTDi4286.
MGIiMGI:104554. Mitf.

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Enzyme and pathway databases

ReactomeiR-MMU-3232118. SUMOylation of transcription factors.

Miscellaneous databases

ChiTaRSiMitf. mouse.
NextBioi291916.
SOURCEiSearch...

Gene expression databases

BgeeiE9QL92.
ExpressionAtlasiE9QL92. baseline and differential.
GenevisibleiE9QL92. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR021802. MiT/TFE_C.
IPR031867. MiT/TFE_N.
IPR030532. MITF.
[Graphical view]
PANTHERiPTHR12565:SF91. PTHR12565:SF91. 2 hits.
PfamiPF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
PF15951. MITF_TFEB_C_3_N. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QL92_MOUSE
AccessioniPrimary (citable) accession number: E9QL92
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 16, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.