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Protein
Submitted name:

Centromere-associated protein E

Gene

Cenpe

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 93ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Submitted name:
Centromere-associated protein EImported
Gene namesi
Name:CenpeImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1098230 Cenpe

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9QKK1
PeptideAtlasiE9QKK1
PRIDEiE9QKK1

Expressioni

Gene expression databases

BgeeiENSMUSG00000045328
ExpressionAtlasiE9QKK1 baseline and differential
GenevisibleiE9QKK1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9QKK1, 83 interactors

Structurei

3D structure databases

ProteinModelPortaliE9QKK1
SMRiE9QKK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 329Kinesin motorInterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 372Sequence analysisAdd BLAST35
Coiled coili496 – 550Sequence analysisAdd BLAST55
Coiled coili559 – 607Sequence analysisAdd BLAST49
Coiled coili644 – 692Sequence analysisAdd BLAST49
Coiled coili715 – 749Sequence analysisAdd BLAST35
Coiled coili826 – 853Sequence analysisAdd BLAST28
Coiled coili861 – 954Sequence analysisAdd BLAST94
Coiled coili966 – 986Sequence analysisAdd BLAST21
Coiled coili1033 – 1151Sequence analysisAdd BLAST119
Coiled coili1155 – 1220Sequence analysisAdd BLAST66
Coiled coili1239 – 1259Sequence analysisAdd BLAST21
Coiled coili1314 – 1380Sequence analysisAdd BLAST67
Coiled coili1384 – 1404Sequence analysisAdd BLAST21
Coiled coili1416 – 1436Sequence analysisAdd BLAST21
Coiled coili1445 – 1524Sequence analysisAdd BLAST80
Coiled coili1544 – 1585Sequence analysisAdd BLAST42
Coiled coili1628 – 1648Sequence analysisAdd BLAST21
Coiled coili1663 – 1711Sequence analysisAdd BLAST49
Coiled coili1736 – 1760Sequence analysisAdd BLAST25
Coiled coili1768 – 1851Sequence analysisAdd BLAST84
Coiled coili1859 – 1907Sequence analysisAdd BLAST49
Coiled coili1933 – 1953Sequence analysisAdd BLAST21
Coiled coili2255 – 2282Sequence analysisAdd BLAST28
Coiled coili2321 – 2362Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
KOiK11498
OMAiSVCRASW
OrthoDBiEOG091G0CFT
TreeFamiTF330343

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 6 hits
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

E9QKK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEASVAVC VRVRPLNSRE EELGEATHIY WKTDKNAIYQ SDGGKSFQFD
60 70 80 90 100
RVFDSNETTK NVYEEIAVPI ISSAIQGYNG TIFAYGQTAS GKTHTMMGSE
110 120 130 140 150
DCLGVIPRAI HDIFQRIKKF PEREFLLRVS YMEIYNETIT DLLCNAQKMK
160 170 180 190 200
PLIIREDTNR TVYVSDLTEE VVYTAEMALK WLATGEKNRH YGITKMNQRS
210 220 230 240 250
SRSHTIFRMI LESREKAEPS NCDGSVKVSH LNLVDLAGSE RAAQTGAEGV
260 270 280 290 300
RLKEGCFINR NLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA
310 320 330 340 350
KTRIICTITP ASLDETLTTL QFASTAKYMK NTPYVNEVSN DEALLKRYRR
360 370 380 390 400
EIADLRKQLE EVNTKTRAQE MEKDQLAQLL DEKDLLQKVQ DEKINNLKRM
410 420 430 440 450
LVTSSSIALQ QELEIKRKRR VTWCYGKMKD SNYEKEFKVP TSITTRKRKT
460 470 480 490 500
SVTSLRENSL MKFGESAASS EFEMLNNTLE SLAEVEWSSA TTLLSEENVE
510 520 530 540 550
SELNSLNAQY NDLVLDYEQL RRENEDLKLK LKEKNELEEF ELLEQKEERD
560 570 580 590 600
QEMQLMHEVS NLKNLIKHAE EYNQDLENDL SSKVKLLKEK EEQIKNLQEY
610 620 630 640 650
IDAQKSEKMK IDLSYTSDAT EDLKQAMRTL SDLDTVALDA KKESAFLRSE
660 670 680 690 700
NLELKEKINE LSDSRKQMES DIQMYQRQLE AKKKMQTDLD KELQLAFQEI
710 720 730 740 750
SKLSALVDGK GLLSNLELEK RITDLQKELN KEAEEKQTLQ EEVNLLSELK
760 770 780 790 800
SLPSEVETLR RELYEKSEEL HIITTEREKL FSEMAHKDSR IQGLLEEIGN
810 820 830 840 850
TRDDLATSQL SRRGSDGEWQ ALESLHAELE HRHAGVLEER ERLKQEIGAL
860 870 880 890 900
SKEAESLAFS LDSVKAELSH KTQELEQKTV EGQERLNKME ALREELESRD
910 920 930 940 950
SSLQSVEKEK VLLTEKLQQA LKEVKALTQE KKNLKQLQES LQTERDQLRS
960 970 980 990 1000
DIQDTVNMNI DTQEQLLNAL ESLKQHQETI NMLKMKAAEE LSDNLHVKDR
1010 1020 1030 1040 1050
GGARDEAQQK MDGIDEQNES AHTLLGGGKD NEVTEEQRKI DSLMQENSGL
1060 1070 1080 1090 1100
QQTLESVRAE KEQLKMDLKE NIEMSIENQE ELRILRDELK RQQEVAAQEK
1110 1120 1130 1140 1150
DHATEKTQEL SRTQERLAKT EEKLEEKNQK LQETQQQLLS TQEAMSKLQA
1160 1170 1180 1190 1200
KVIDMESLQN EFRNQGLALE RVETEKLELA QRLHESYEEV KSITKERNDL
1210 1220 1230 1240 1250
KELQESFEIE KKQLKEYARE IEAAGLQTKE ELNIAHANLK EYQEIITELR
1260 1270 1280 1290 1300
GSISENEAQG ASTQDTAKSA PELQGEVPEQ ELLPVVKEAR HSAEKVNGLE
1310 1320 1330 1340 1350
PVGAHSRTVH SMTMEGIEIE NLRLTKKLEE SQMEISCLTR EREDLRRTQE
1360 1370 1380 1390 1400
TLQVECTQLK EDARRTLANH LETEEELNLA RCCLKEQENK IDTLITSLSQ
1410 1420 1430 1440 1450
RETELSSVRG QLALTTAELE RKVQELCEKQ EELTRKETSE AQGKMSELEQ
1460 1470 1480 1490 1500
LRELLLAQAS ALQNAESDRL RLNTQLEESQ EEMKTLREER EELRRMQEAL
1510 1520 1530 1540 1550
HVESEQQKES MKEISSKLQE LQNKEYECLA MKTINETQGS RCEMDHLNQQ
1560 1570 1580 1590 1600
LEAQKSTLEK VEMENVNLTQ RLHETLEEMR SVAKERDELW SMEERLTVER
1610 1620 1630 1640 1650
DQLKKSLEET VTKGMEKEEE LRVAHVHLEE HQETINKLRK MVSDYTDEIS
1660 1670 1680 1690 1700
HTQGDLKHTN AVVEAQNQDL REKEHQLSQV KADLRETVDQ MEQLKKKLEA
1710 1720 1730 1740 1750
QSSTLESREI EKLELTQQLN ENLKKITLVT KENDSLKIMD EALREERDQL
1760 1770 1780 1790 1800
RKSLQQTEAR DLENQEKLRI AHMNLKEHQE TIDRLMETMS EKTEEISNMK
1810 1820 1830 1840 1850
MELENVNMKL QEKVQELKTS ERQRVKLKAD ASEAKKELKE QGLTLSKIEM
1860 1870 1880 1890 1900
ENLNLAQKIH ENLEEMKSVR KERDDLKKLE EILRMERDQL KDNLREAMLK
1910 1920 1930 1940 1950
AHQNHEETMK CGKGLLCAGE YCTGRLREKC FRIEKLLKRY SEMANDYECL
1960 1970 1980 1990 2000
NKVSLDLERE TKTQKELSVT VRTKLSLPHT QTKEMEKLLT ANQRCSLEFH
2010 2020 2030 2040 2050
RALKRLKYVL SSIARIKEEQ HESINKREMA FIQEVEKQNE LQIQIQSLSQ
2060 2070 2080 2090 2100
TYRIPARDLQ IKLSQEMDLH IEEMLKDFSE NDFLTIKTEV QQVLNNRKEI
2110 2120 2130 2140 2150
TEFLGKWLNT LFDTENLKST IQKENKSIGL VNNFYHSRIT AMINESTEFE
2160 2170 2180 2190 2200
ERSATRSKDL DQYLKSLKET TEQLSEVYQT LTASQSVVHL HPTVQPSTRD
2210 2220 2230 2240 2250
SERPQAASGA EQLTSKNKIA LGAVPYKEEI EDLKMQLVKS DLEKKATAKE
2260 2270 2280 2290 2300
FDKKILSLKA TVEHQEEMIR LLRENLRGHQ QAQDTSMISE QDSQLLSKPL
2310 2320 2330 2340 2350
TCGGGSGIVQ STKALILKSE YKRMGSEISK LKQQNEQLRK QNNQLLSDNS
2360 2370 2380 2390 2400
QLSNEVKTWE ERTLKRDSYR ETTCENSPKS PKVTRTDSKR RQNTTSQCRA
2410 2420 2430 2440 2450
QNLQDPVPKD SPKSWFFDNR SKSLPAPHPI RYFDNSSLGL CPEPDDVENV
2460 2470
EPKTDLCQAS LEKDVSQCKT Q
Length:2,471
Mass (Da):286,214
Last modified:April 5, 2011 - v1
Checksum:i8F6043A3BF3804EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104874 Genomic DNA No translation available.
RefSeqiNP_776123.3, NM_173762.4
UniGeneiMm.161470

Genome annotation databases

EnsembliENSMUST00000062893; ENSMUSP00000057938; ENSMUSG00000045328
GeneIDi229841
KEGGimmu:229841
UCSCiuc008rkz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QKK1_MOUSE
AccessioniPrimary (citable) accession number: E9QKK1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health