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Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei645 – 6451Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-190377. FGFR2b ligand binding and activation.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei394 – 41623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiE9QK53.
PRIDEiE9QK53.

Expressioni

Gene expression databases

BgeeiE9QK53.
ExpressionAtlasiE9QK53. baseline and differential.
GenevisibleiE9QK53. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112430.

Structurei

3D structure databases

ProteinModelPortaliE9QK53.
SMRiE9QK53. Positions 15-391, 481-820.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 14487Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini173 – 26694Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini275 – 377103Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini500 – 789290Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
KOiK05093.
TreeFamiTF316307.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QK53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEEPPTK YQISQPEAYV VAPGESLELQ CMLKDAAVIS WTKDGVHLGP
110 120 130 140 150
NNRTVLIGEY LQIKGATPRD SGLYACTAAR TVDSETWYFM VNVTDAISSG
160 170 180 190 200
DDEDDTDSSE DVVSENRSNQ RAPYWTNTEK MEKRLHAVPA ANTVKFRCPA
210 220 230 240 250
GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC
260 270 280 290 300
LVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY
310 320 330 340 350
SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN
360 370 380 390 400
VTFEDAGEYT CLAGNSIGIS FHSAWLTVLP APVREKEITA SPDYLEIAIY
410 420 430 440 450
CIGVFLIACM VVTVIFCRMK TTTKKPDFSS QPAVHKLTKR IPLRRQVTVS
460 470 480 490 500
AESSSSMNSN TPLVRITTRL SSTADTPMLA GVSEYELPED PKWEFPRDKL
510 520 530 540 550
TLGKPLGEGC FGQVVMAEAV GIDKDKPKEA VTVAVKMLKD DATEKDLSDL
560 570 580 590 600
VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREYLRARRP
610 620 630 640 650
PGMEYSYDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN
660 670 680 690 700
VLVTENNVMK IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT
710 720 730 740 750
HQSDVWSFGV LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPTNCTNE
760 770 780 790 800
LYMMMRDCWH AVPSQRPTFK QLVEDLDRIL TLTTNEEYLD LTQPLEQYSP
810 820 830 840
SYPDTRSSCS SGDDSVFSPD PMPYEPCLPQ YPHINGSVKT
Length:840
Mass (Da):94,146
Last modified:April 5, 2011 - v1
Checksum:iDF2F91B09324215C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
RefSeqiNP_034337.2. NM_010207.2.
UniGeneiMm.16340.

Genome annotation databases

EnsembliENSMUST00000122054; ENSMUSP00000112430; ENSMUSG00000030849.
GeneIDi14183.
KEGGimmu:14183.
UCSCiuc033jcj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
RefSeqiNP_034337.2. NM_010207.2.
UniGeneiMm.16340.

3D structure databases

ProteinModelPortaliE9QK53.
SMRiE9QK53. Positions 15-391, 481-820.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112430.

Proteomic databases

PaxDbiE9QK53.
PRIDEiE9QK53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000122054; ENSMUSP00000112430; ENSMUSG00000030849.
GeneIDi14183.
KEGGimmu:14183.
UCSCiuc033jcj.1. mouse.

Organism-specific databases

CTDi2263.
MGIiMGI:95523. Fgfr2.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
KOiK05093.
TreeFamiTF316307.

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-190377. FGFR2b ligand binding and activation.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

ChiTaRSiFgfr2. mouse.
NextBioi285386.
SOURCEiSearch...

Gene expression databases

BgeeiE9QK53.
ExpressionAtlasiE9QK53. baseline and differential.
GenevisibleiE9QK53. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QK53_MOUSE
AccessioniPrimary (citable) accession number: E9QK53
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 16, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.