Fibroblast growth factor receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the ‘Names and taxonomy’ section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• fibroblast growth factor-activated receptor activity Source: Ensembl
• fibroblast growth factor binding Source: Ensembl
• protein homodimerization activity Source: Ensembl

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cellular response to retinoic acid Source: Ensembl
• cellular response to transforming growth factor beta stimulus Source: Ensembl
• embryonic cranial skeleton morphogenesis Source: Ensembl
• endochondral bone growth Source: Ensembl
• epithelial to mesenchymal transition Source: Ensembl
• mesodermal cell differentiation Source: Ensembl
• negative regulation of epithelial cell proliferation Source: Ensembl
• positive regulation of MAPK cascade Source: Ensembl
• positive regulation of phospholipase activity Source: Ensembl
• positive regulation of smooth muscle cell proliferation Source: Ensembl
• protein autophosphorylation Source: Ensembl
• response to ethanol Source: Ensembl
• response to lipopolysaccharide Source: Ensembl
• wound healing Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• cell cortex Source: Ensembl
• cell surface Source: Ensembl
• extracellular matrix Source: Ensembl
• integral component of plasma membrane Source: Ensembl
• nucleoplasm Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• fibroblast growth factor binding Source: Ensembl
• protein homodimerization activity Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT 
        60         70         80         90        100
TLEPEEPPTK YQISQPEAYV VAPGESLELQ CMLKDAAVIS WTKDGVHLGP 
       110        120        130        140        150
NNRTVLIGEY LQIKGATPRD SGLYACTAAR TVDSETWYFM VNVTDAISSG 
       160        170        180        190        200
DDEDDTDSSE DVVSENRSNQ RAPYWTNTEK MEKRLHAVPA ANTVKFRCPA 
       210        220        230        240        250
GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC 
       260        270        280        290        300
LVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 
       310        320        330        340        350
SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN 
       360        370        380        390        400
VTFEDAGEYT CLAGNSIGIS FHSAWLTVLP APVREKEITA SPDYLEIAIY 
       410        420        430        440        450
CIGVFLIACM VVTVIFCRMK TTTKKPDFSS QPAVHKLTKR IPLRRQVTVS 
       460        470        480        490        500
AESSSSMNSN TPLVRITTRL SSTADTPMLA GVSEYELPED PKWEFPRDKL 
       510        520        530        540        550
TLGKPLGEGC FGQVVMAEAV GIDKDKPKEA VTVAVKMLKD DATEKDLSDL 
       560        570        580        590        600
VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREYLRARRP 
       610        620        630        640        650
PGMEYSYDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN 
       660        670        680        690        700
VLVTENNVMK IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT 
       710        720        730        740        750
HQSDVWSFGV LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPTNCTNE 
       760        770        780        790        800
LYMMMRDCWH AVPSQRPTFK QLVEDLDRIL TLTTNEEYLD LTQPLEQYSP 
       810        820        830        840
SYPDTRSSCS SGDDSVFSPD PMPYEPCLPQ YPHINGSVKT            

Sequence databases

Genome annotation databases

<p>This section provides links to the UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Caution

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ