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E9QK53

- E9QK53_MOUSE

UniProt

E9QK53 - E9QK53_MOUSE

Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei645 – 6451Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fibroblast growth factor-activated receptor activity Source: Ensembl
    3. fibroblast growth factor binding Source: MGI
    4. protein binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. axonogenesis Source: MGI
    3. bone development Source: MGI
    4. bone mineralization Source: MGI
    5. bone morphogenesis Source: MGI
    6. branch elongation involved in salivary gland morphogenesis Source: MGI
    7. branching involved in labyrinthine layer morphogenesis Source: MGI
    8. branching involved in prostate gland morphogenesis Source: MGI
    9. branching involved in salivary gland morphogenesis Source: MGI
    10. branching morphogenesis of a nerve Source: MGI
    11. bud elongation involved in lung branching Source: MGI
    12. cell-cell signaling Source: MGI
    13. cell fate commitment Source: MGI
    14. coronal suture morphogenesis Source: MGI
    15. digestive tract development Source: MGI
    16. embryonic cranial skeleton morphogenesis Source: Ensembl
    17. embryonic digestive tract morphogenesis Source: MGI
    18. embryonic organ development Source: MGI
    19. embryonic organ morphogenesis Source: MGI
    20. embryonic pattern specification Source: MGI
    21. endodermal digestive tract morphogenesis Source: MGI
    22. epidermis morphogenesis Source: MGI
    23. epithelial cell differentiation Source: MGI
    24. epithelial cell proliferation Source: MGI
    25. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
    26. epithelial to mesenchymal transition Source: Ensembl
    27. epithelial tube branching involved in lung morphogenesis Source: MGI
    28. fibroblast growth factor receptor signaling pathway Source: MGI
    29. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
    30. gland morphogenesis Source: MGI
    31. hair follicle morphogenesis Source: MGI
    32. inner ear morphogenesis Source: MGI
    33. in utero embryonic development Source: MGI
    34. lacrimal gland development Source: MGI
    35. lateral sprouting from an epithelium Source: MGI
    36. lens fiber cell development Source: MGI
    37. limb bud formation Source: MGI
    38. lung alveolus development Source: MGI
    39. lung-associated mesenchyme development Source: MGI
    40. lung development Source: MGI
    41. lung lobe morphogenesis Source: MGI
    42. mammary gland bud formation Source: MGI
    43. membranous septum morphogenesis Source: MGI
    44. mesenchymal cell differentiation Source: MGI
    45. mesenchymal cell differentiation involved in lung development Source: MGI
    46. mesenchymal cell proliferation involved in lung development Source: MGI
    47. mesodermal cell differentiation Source: Ensembl
    48. midbrain development Source: MGI
    49. morphogenesis of embryonic epithelium Source: MGI
    50. multicellular organism growth Source: MGI
    51. negative regulation of cell proliferation Source: MGI
    52. negative regulation of epithelial cell proliferation Source: Ensembl
    53. negative regulation of mitosis Source: MGI
    54. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    55. neuromuscular junction development Source: MGI
    56. odontogenesis Source: MGI
    57. organ growth Source: MGI
    58. organ morphogenesis Source: MGI
    59. otic vesicle formation Source: MGI
    60. outflow tract septum morphogenesis Source: MGI
    61. positive regulation of canonical Wnt signaling pathway Source: MGI
    62. positive regulation of cardiac muscle cell proliferation Source: MGI
    63. positive regulation of cell division Source: MGI
    64. positive regulation of cell proliferation Source: MGI
    65. positive regulation of epithelial cell proliferation Source: MGI
    66. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
    67. positive regulation of ERK1 and ERK2 cascade Source: MGI
    68. positive regulation of mesenchymal cell proliferation Source: MGI
    69. positive regulation of phospholipase activity Source: Ensembl
    70. positive regulation of smooth muscle cell proliferation Source: Ensembl
    71. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    72. positive regulation of Wnt signaling pathway Source: MGI
    73. post-embryonic development Source: MGI
    74. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
    75. prostate epithelial cord elongation Source: MGI
    76. prostate gland morphogenesis Source: MGI
    77. protein autophosphorylation Source: Ensembl
    78. regulation of branching involved in prostate gland morphogenesis Source: MGI
    79. regulation of cell fate commitment Source: MGI
    80. regulation of cell proliferation Source: MGI
    81. regulation of epithelial cell proliferation Source: MGI
    82. regulation of ERK1 and ERK2 cascade Source: MGI
    83. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
    84. regulation of morphogenesis of a branching structure Source: MGI
    85. regulation of multicellular organism growth Source: MGI
    86. regulation of smoothened signaling pathway Source: MGI
    87. regulation of smooth muscle cell differentiation Source: MGI
    88. reproductive structure development Source: MGI
    89. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
    90. synaptic vesicle transport Source: MGI
    91. ureteric bud development Source: MGI
    92. ventricular cardiac muscle tissue morphogenesis Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196534. Signaling by FGFR2 amplification mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
    Gene namesi
    Name:Fgfr2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95523. Fgfr2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. cell surface Source: Ensembl
    3. extracellular matrix Source: Ensembl
    4. extracellular region Source: MGI
    5. integral component of plasma membrane Source: Ensembl
    6. nucleus Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Proteomic databases

    PRIDEiE9QK53.

    Expressioni

    Gene expression databases

    ArrayExpressiE9QK53.
    BgeeiE9QK53.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QK53.
    SMRiE9QK53. Positions 15-382, 481-820.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00670000097694.
    KOiK05093.
    TreeFamiTF316307.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR028175. FGF_rcpt_2.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
    PfamiPF07679. I-set. 3 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000628. FGFR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QK53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT    50
    TLEPEEPPTK YQISQPEAYV VAPGESLELQ CMLKDAAVIS WTKDGVHLGP 100
    NNRTVLIGEY LQIKGATPRD SGLYACTAAR TVDSETWYFM VNVTDAISSG 150
    DDEDDTDSSE DVVSENRSNQ RAPYWTNTEK MEKRLHAVPA ANTVKFRCPA 200
    GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC 250
    LVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300
    SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN 350
    VTFEDAGEYT CLAGNSIGIS FHSAWLTVLP APVREKEITA SPDYLEIAIY 400
    CIGVFLIACM VVTVIFCRMK TTTKKPDFSS QPAVHKLTKR IPLRRQVTVS 450
    AESSSSMNSN TPLVRITTRL SSTADTPMLA GVSEYELPED PKWEFPRDKL 500
    TLGKPLGEGC FGQVVMAEAV GIDKDKPKEA VTVAVKMLKD DATEKDLSDL 550
    VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREYLRARRP 600
    PGMEYSYDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN 650
    VLVTENNVMK IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT 700
    HQSDVWSFGV LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPTNCTNE 750
    LYMMMRDCWH AVPSQRPTFK QLVEDLDRIL TLTTNEEYLD LTQPLEQYSP 800
    SYPDTRSSCS SGDDSVFSPD PMPYEPCLPQ YPHINGSVKT 840
    Length:840
    Mass (Da):94,146
    Last modified:April 5, 2011 - v1
    Checksum:iDF2F91B09324215C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087063 Genomic DNA. No translation available.
    AC099609 Genomic DNA. No translation available.
    AC099627 Genomic DNA. No translation available.
    AC100735 Genomic DNA. No translation available.
    AC101690 Genomic DNA. No translation available.
    AC101762 Genomic DNA. No translation available.
    AC105062 Genomic DNA. No translation available.
    AC110885 Genomic DNA. No translation available.
    AC111058 Genomic DNA. No translation available.
    AC115697 Genomic DNA. No translation available.
    AC119806 Genomic DNA. No translation available.
    AC122258 Genomic DNA. No translation available.
    AC126688 Genomic DNA. No translation available.
    AC138624 Genomic DNA. No translation available.
    AC145294 Genomic DNA. No translation available.
    AC149596 Genomic DNA. No translation available.
    AC156606 Genomic DNA. No translation available.
    AC157606 Genomic DNA. No translation available.
    AC158113 Genomic DNA. No translation available.
    AC158314 Genomic DNA. No translation available.
    AC159994 Genomic DNA. No translation available.
    AC175034 Genomic DNA. No translation available.
    AC238818 Genomic DNA. No translation available.
    RefSeqiNP_034337.2. NM_010207.2.
    UniGeneiMm.16340.

    Genome annotation databases

    EnsembliENSMUST00000122054; ENSMUSP00000112430; ENSMUSG00000030849.
    GeneIDi14183.
    KEGGimmu:14183.
    UCSCiuc009jzt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087063 Genomic DNA. No translation available.
    AC099609 Genomic DNA. No translation available.
    AC099627 Genomic DNA. No translation available.
    AC100735 Genomic DNA. No translation available.
    AC101690 Genomic DNA. No translation available.
    AC101762 Genomic DNA. No translation available.
    AC105062 Genomic DNA. No translation available.
    AC110885 Genomic DNA. No translation available.
    AC111058 Genomic DNA. No translation available.
    AC115697 Genomic DNA. No translation available.
    AC119806 Genomic DNA. No translation available.
    AC122258 Genomic DNA. No translation available.
    AC126688 Genomic DNA. No translation available.
    AC138624 Genomic DNA. No translation available.
    AC145294 Genomic DNA. No translation available.
    AC149596 Genomic DNA. No translation available.
    AC156606 Genomic DNA. No translation available.
    AC157606 Genomic DNA. No translation available.
    AC158113 Genomic DNA. No translation available.
    AC158314 Genomic DNA. No translation available.
    AC159994 Genomic DNA. No translation available.
    AC175034 Genomic DNA. No translation available.
    AC238818 Genomic DNA. No translation available.
    RefSeqi NP_034337.2. NM_010207.2.
    UniGenei Mm.16340.

    3D structure databases

    ProteinModelPortali E9QK53.
    SMRi E9QK53. Positions 15-382, 481-820.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9QK53.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000122054 ; ENSMUSP00000112430 ; ENSMUSG00000030849 .
    GeneIDi 14183.
    KEGGi mmu:14183.
    UCSCi uc009jzt.1. mouse.

    Organism-specific databases

    CTDi 2263.
    MGIi MGI:95523. Fgfr2.

    Phylogenomic databases

    GeneTreei ENSGT00670000097694.
    KOi K05093.
    TreeFami TF316307.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196534. Signaling by FGFR2 amplification mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    ChiTaRSi FGFR2. mouse.
    NextBioi 285386.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9QK53.
    Bgeei E9QK53.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR028175. FGF_rcpt_2.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
    Pfami PF07679. I-set. 3 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000628. FGFR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QK53_MOUSE
    AccessioniPrimary (citable) accession number: E9QK53
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3