ID   E9QJS1_MOUSE            Unreviewed;      1207 AA.
AC   E9QJS1;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000636};
DE            EC=2.7.10.2 {ECO:0000256|PIRNR:PIRNR000636};
GN   Name=Tyk2 {ECO:0000313|Ensembl:ENSMUSP00000001036.11,
GN   ECO:0000313|MGI:MGI:1929470};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000001036.11, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:17947660}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17947660;
RA   Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA   Kawakami T., Salomon A.R.;
RT   "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT   signaling.";
RL   J. Immunol. 179:5864-5876(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000001036.11, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000001036.11,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000001036.11}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000001036.11};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001149,
CC         ECO:0000256|PIRNR:PIRNR000636};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. JAK subfamily. {ECO:0000256|PIRNR:PIRNR000636}.
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DR   RefSeq; NP_001192241.1; NM_001205312.1.
DR   ProteomicsDB; 332550; -.
DR   Antibodypedia; 716; 787 antibodies from 41 providers.
DR   DNASU; 54721; -.
DR   Ensembl; ENSMUST00000001036.11; ENSMUSP00000001036.11; ENSMUSG00000032175.12.
DR   Ensembl; ENSMUST00000216874.2; ENSMUSP00000150354.2; ENSMUSG00000032175.12.
DR   GeneID; 54721; -.
DR   UCSC; uc012gpb.1; mouse.
DR   AGR; MGI:1929470; -.
DR   CTD; 7297; -.
DR   MGI; MGI:1929470; Tyk2.
DR   VEuPathDB; HostDB:ENSMUSG00000032175; -.
DR   GeneTree; ENSGT00940000159869; -.
DR   HOGENOM; CLU_008155_1_0_1; -.
DR   OMA; QAKHEFV; -.
DR   OrthoDB; 1614410at2759; -.
DR   TreeFam; TF327041; -.
DR   BioGRID-ORCS; 54721; 7 hits in 79 CRISPR screens.
DR   ChiTaRS; Tyk2; mouse.
DR   Proteomes; UP000000589; Chromosome 9.
DR   Bgee; ENSMUSG00000032175; Expressed in granulocyte and 234 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-UniRule.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:Ensembl.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031702; F:type 1 angiotensin receptor binding; IEA:Ensembl.
DR   GO; GO:0035722; P:interleukin-12-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0060333; P:type II interferon-mediated signaling pathway; IEA:Ensembl.
DR   CDD; cd05080; PTKc_Tyk2_rpt2; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR041155; FERM_F1.
DR   InterPro; IPR041046; FERM_F2.
DR   InterPro; IPR041381; JAK1-3/TYK2_PHL_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
DR   InterPro; IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
DR   PANTHER; PTHR45807:SF6; NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2; 1.
DR   PANTHER; PTHR45807; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR   Pfam; PF18379; FERM_F1; 1.
DR   Pfam; PF18377; FERM_F2; 1.
DR   Pfam; PF17887; Jak1_Phl; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR   PIRSF; PIRSF000636; TyrPK_Jak; 1.
DR   PRINTS; PR01823; JANUSKINASE.
DR   PRINTS; PR00109; TYRKINASE.
DR   PRINTS; PR01827; YKINASETYK2.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00219; TyrKc; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   Genevisible; E9QJS1; MM.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|PIRSR:PIRSR000636-
KW   2}; Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000636};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000636,
KW   ECO:0000256|PIRSR:PIRSR000636-2};
KW   Proteomics identification {ECO:0007829|EPD:E9QJS1,
KW   ECO:0007829|MaxQB:E9QJS1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000636};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW   ECO:0000256|PIRNR:PIRNR000636}.
FT   DOMAIN          33..453
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          612..889
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          917..1189
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          317..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1043
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
FT   BINDING         923..931
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-2"
FT   BINDING         950
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1207 AA;  135901 MW;  7207FF710AC80CE1 CRC64;
     MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT FSQTSLTAEE
     VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ DMNLYFRMRF YFRNWHGMNP
     QEPAVYRCGF PGAETSSDRA EQGVQLLDSA SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP
     QGKHEFMNDV VSLRDLSSEE EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC
     IPHSFRQHIR QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER
     IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI QWHPLQTQES
     ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC DFQDISHVVL KERRVHIHLQ
     DNKCLLLCLC SQAEALSFVA LVDGYFRLTA DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP
     FVQAKLWPED GLYLIQWSTS HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD
     GWGRSFASLG DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS
     QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG GTSGQQLRVV
     LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG SENIIVTEFV EHGPLDVWLR
     RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL VHGNVCGRNI LLARLGLEEG TNPFIKLSDP
     GVGQGALSRE ERVERIPWTA PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP
     SEKERFYTKK HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV
     NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKEGCGPQL
     RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY VPLGSLRDYL PRHCVGLAQL
     LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED
     GDSPVFWYAP ECLKECKFYY ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT
     VLRLTELLER GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV
     PSVFSVC
//