Tyrosine-protein kinase - Mus musculus (Mouse)

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E9QJS1 (E9QJS1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase RuleBase RU003492
EC=2.7.10.2 RuleBase RU003492

Gene names

Name:

Tyk2 Ensembl ENSMUSP00000001036 MGI 1929470

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000001036

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1207 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. RuleBase RU003492 SAAS SAAS008266

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. RuleBase RU003492

Contains 1 SH2 domain. RuleBase RU003492

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000001036

Ontologies

Keywords
Domain	SH2 domain RuleBase RU003492
Ligand	ATP-binding SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS008266
PTM	Phosphoprotein RuleBase RU003493
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein kinase cascade Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara cytoskeleton Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

E9QJS1 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 7207FF710AC80CE1
Show »

FASTA

1,207

135,901

        10         20         30         40         50         60 
MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT FSQTSLTAEE 

        70         80         90        100        110        120 
VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ DMNLYFRMRF YFRNWHGMNP 

       130        140        150        160        170        180 
QEPAVYRCGF PGAETSSDRA EQGVQLLDSA SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP 

       190        200        210        220        230        240 
QGKHEFMNDV VSLRDLSSEE EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC 

       250        260        270        280        290        300 
IPHSFRQHIR QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER 

       310        320        330        340        350        360 
IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI QWHPLQTQES 

       370        380        390        400        410        420 
ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC DFQDISHVVL KERRVHIHLQ 

       430        440        450        460        470        480 
DNKCLLLCLC SQAEALSFVA LVDGYFRLTA DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP 

       490        500        510        520        530        540 
FVQAKLWPED GLYLIQWSTS HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD 

       550        560        570        580        590        600 
GWGRSFASLG DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS 

       610        620        630        640        650        660 
QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG GTSGQQLRVV 

       670        680        690        700        710        720 
LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG SENIIVTEFV EHGPLDVWLR 

       730        740        750        760        770        780 
RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL VHGNVCGRNI LLARLGLEEG TNPFIKLSDP 

       790        800        810        820        830        840 
GVGQGALSRE ERVERIPWTA PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP 

       850        860        870        880        890        900 
SEKERFYTKK HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV 

       910        920        930        940        950        960 
NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKEGCGPQL 

       970        980        990       1000       1010       1020 
RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY VPLGSLRDYL PRHCVGLAQL 

      1030       1040       1050       1060       1070       1080 
LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED 

      1090       1100       1110       1120       1130       1140 
GDSPVFWYAP ECLKECKFYY ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT 

      1150       1160       1170       1180       1190       1200 
VLRLTELLER GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV 


PSVFSVC

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000001036.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000001036.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC163637 Genomic DNA. No translation available.
IPI	IPI01016145.
RefSeq	NP_001192241.1. NM_001205312.1.
UniGene	Mm.20249. Mm.450004.
3D structure databases
ProteinModelPortal	E9QJS1.
SMR	E9QJS1. Positions 604-1197.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001036; ENSMUSP00000001036; ENSMUSG00000032175.
GeneID	54721.
KEGG	mmu:54721.
Organism-specific databases
CTD	7297.
MGI	MGI:1929470. Tyk2.
Phylogenomic databases
GeneTree	ENSGT00630000089536.
KO	K11219.
OMA	HAQHYIH.
Gene expression databases
ArrayExpress	E9QJS1.
Bgee	E9QJS1.
Family and domain databases
InterPro	IPR019749. Band_41_domain. IPR000299. FERM_domain. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2. IPR016045. Tyr_kinase_non-rcpt_TYK2_N. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 2 hits. [Graphical view]
PIRSF	PIRSF000636. TyrPK_Jak. 1 hit.
PRINTS	PR01823. JANUSKINASE. PR00109. TYRKINASE. PR01827. YKINASETYK2.
SMART	SM00295. B41. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 2 hits. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 2 hits.
PROSITE	PS50057. FERM_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TYK2. mouse.
NextBio	311570.
SOURCE	Search...

Entry information

Entry name

E9QJS1_MOUSE

Accession

Primary (citable) accession number: E9QJS1

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information