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Protein

Tyrosine-protein kinase

Gene

Tyk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei950ATPUniRule annotation1
Active sitei1043Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi923 – 931ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation
R-MMU-6783783 Interleukin-10 signaling
R-MMU-6785807 Interleukin-4 and 13 signaling
R-MMU-6788467 IL-6-type cytokine receptor ligand interactions
R-MMU-8854691 Interleukin-20 family signaling
R-MMU-8984722 Interleukin-35 Signalling
R-MMU-9020591 Interleukin-12 signaling
R-MMU-9020933 Interleukin-23 signaling
R-MMU-9020956 Interleukin-27 signaling
R-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:Tyk2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1929470 Tyk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9QJS1
PeptideAtlasiE9QJS1

Expressioni

Gene expression databases

BgeeiENSMUSG00000032175
GenevisibleiE9QJS1 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiE9QJS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 453FERMInterPro annotationAdd BLAST421
Domaini612 – 889Protein kinaseInterPro annotationAdd BLAST278
Domaini917 – 1189Protein kinaseInterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909
KOiK11219
OMAiTVFHKRY
OrthoDBiEOG091G01IS
TreeFamiTF327041

Family and domain databases

InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

E9QJS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT
60 70 80 90 100
FSQTSLTAEE VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ
110 120 130 140 150
DMNLYFRMRF YFRNWHGMNP QEPAVYRCGF PGAETSSDRA EQGVQLLDSA
160 170 180 190 200
SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP QGKHEFMNDV VSLRDLSSEE
210 220 230 240 250
EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC IPHSFRQHIR
260 270 280 290 300
QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER
310 320 330 340 350
IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI
360 370 380 390 400
QWHPLQTQES ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC
410 420 430 440 450
DFQDISHVVL KERRVHIHLQ DNKCLLLCLC SQAEALSFVA LVDGYFRLTA
460 470 480 490 500
DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP FVQAKLWPED GLYLIQWSTS
510 520 530 540 550
HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD GWGRSFASLG
560 570 580 590 600
DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS
610 620 630 640 650
QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG
660 670 680 690 700
GTSGQQLRVV LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG
710 720 730 740 750
SENIIVTEFV EHGPLDVWLR RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL
760 770 780 790 800
VHGNVCGRNI LLARLGLEEG TNPFIKLSDP GVGQGALSRE ERVERIPWTA
810 820 830 840 850
PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP SEKERFYTKK
860 870 880 890 900
HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV
910 920 930 940 950
NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK
960 970 980 990 1000
ALKEGCGPQL RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY
1010 1020 1030 1040 1050
VPLGSLRDYL PRHCVGLAQL LLFAQQICEG MAYLHAQHYI HRDLAARNVL
1060 1070 1080 1090 1100
LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP ECLKECKFYY
1110 1120 1130 1140 1150
ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT VLRLTELLER
1160 1170 1180 1190 1200
GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV

PSVFSVC
Length:1,207
Mass (Da):135,901
Last modified:April 5, 2011 - v1
Checksum:i7207FF710AC80CE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163637 Genomic DNA No translation available.
RefSeqiNP_001192241.1, NM_001205312.1
UniGeneiMm.20249
Mm.450004

Genome annotation databases

EnsembliENSMUST00000001036; ENSMUSP00000001036; ENSMUSG00000032175
ENSMUST00000216874; ENSMUSP00000150354; ENSMUSG00000032175
GeneIDi54721
KEGGimmu:54721
UCSCiuc012gpb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QJS1_MOUSE
AccessioniPrimary (citable) accession number: E9QJS1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health