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Protein

Tyrosine-protein kinase

Gene

Tyk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1043 – 10431Proton acceptorUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. growth hormone receptor binding Source: MGI
  3. hormone receptor binding Source: GO_Central
  4. non-membrane spanning protein tyrosine kinase activity Source: GO_Central

GO - Biological processi

  1. cell differentiation Source: GO_Central
  2. cell migration Source: GO_Central
  3. innate immune response Source: GO_Central
  4. intracellular signal transduction Source: InterPro
  5. peptidyl-tyrosine autophosphorylation Source: GO_Central
  6. regulation of cell proliferation Source: GO_Central
  7. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:Tyk2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1929470. Tyk2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytoskeleton Source: InterPro
  3. extracellular vesicular exosome Source: MGI
  4. extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
  5. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiE9QJS1.
ExpressionAtlasiE9QJS1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9QJS1.
SMRiE9QJS1. Positions 31-589, 600-890, 907-1197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation
Contains 1 FERM domain.UniRule annotation
Contains 1 SH2 domain.UniRule annotation
Contains 4 protein kinase domains.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118799.
KOiK11219.
OMAiFCDFQDI.
OrthoDBiEOG7BW0HM.
TreeFamiTF327041.

Family and domain databases

InterProiIPR019749. Band_41_domain.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QJS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT
60 70 80 90 100
FSQTSLTAEE VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ
110 120 130 140 150
DMNLYFRMRF YFRNWHGMNP QEPAVYRCGF PGAETSSDRA EQGVQLLDSA
160 170 180 190 200
SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP QGKHEFMNDV VSLRDLSSEE
210 220 230 240 250
EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC IPHSFRQHIR
260 270 280 290 300
QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER
310 320 330 340 350
IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI
360 370 380 390 400
QWHPLQTQES ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC
410 420 430 440 450
DFQDISHVVL KERRVHIHLQ DNKCLLLCLC SQAEALSFVA LVDGYFRLTA
460 470 480 490 500
DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP FVQAKLWPED GLYLIQWSTS
510 520 530 540 550
HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD GWGRSFASLG
560 570 580 590 600
DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS
610 620 630 640 650
QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG
660 670 680 690 700
GTSGQQLRVV LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG
710 720 730 740 750
SENIIVTEFV EHGPLDVWLR RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL
760 770 780 790 800
VHGNVCGRNI LLARLGLEEG TNPFIKLSDP GVGQGALSRE ERVERIPWTA
810 820 830 840 850
PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP SEKERFYTKK
860 870 880 890 900
HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV
910 920 930 940 950
NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK
960 970 980 990 1000
ALKEGCGPQL RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY
1010 1020 1030 1040 1050
VPLGSLRDYL PRHCVGLAQL LLFAQQICEG MAYLHAQHYI HRDLAARNVL
1060 1070 1080 1090 1100
LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP ECLKECKFYY
1110 1120 1130 1140 1150
ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT VLRLTELLER
1160 1170 1180 1190 1200
GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV

PSVFSVC
Length:1,207
Mass (Da):135,901
Last modified:April 5, 2011 - v1
Checksum:i7207FF710AC80CE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163637 Genomic DNA. No translation available.
RefSeqiNP_001192241.1. NM_001205312.1.
UniGeneiMm.20249.
Mm.450004.

Genome annotation databases

EnsembliENSMUST00000001036; ENSMUSP00000001036; ENSMUSG00000032175.
GeneIDi54721.
KEGGimmu:54721.
UCSCiuc012gpb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163637 Genomic DNA. No translation available.
RefSeqiNP_001192241.1. NM_001205312.1.
UniGeneiMm.20249.
Mm.450004.

3D structure databases

ProteinModelPortaliE9QJS1.
SMRiE9QJS1. Positions 31-589, 600-890, 907-1197.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001036; ENSMUSP00000001036; ENSMUSG00000032175.
GeneIDi54721.
KEGGimmu:54721.
UCSCiuc012gpb.1. mouse.

Organism-specific databases

CTDi7297.
MGIiMGI:1929470. Tyk2.

Phylogenomic databases

GeneTreeiENSGT00760000118799.
KOiK11219.
OMAiFCDFQDI.
OrthoDBiEOG7BW0HM.
TreeFamiTF327041.

Enzyme and pathway databases

ReactomeiREACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.

Miscellaneous databases

ChiTaRSiTyk2. mouse.
NextBioi311570.
SOURCEiSearch...

Gene expression databases

BgeeiE9QJS1.
ExpressionAtlasiE9QJS1. baseline and differential.

Family and domain databases

InterProiIPR019749. Band_41_domain.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QJS1_MOUSE
AccessioniPrimary (citable) accession number: E9QJS1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.