Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

E9QJS1

- E9QJS1_MOUSE

UniProt

E9QJS1 - E9QJS1_MOUSE

Protein

Tyrosine-protein kinase

Gene

Tyk2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei950 – 9501ATP
    Active sitei1043 – 10431Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi923 – 9319ATP

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
    Gene namesi
    Name:Tyk2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1929470. Tyk2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. cytoskeleton Source: InterPro
    3. membrane Source: InterPro
    4. nucleus Source: Ensembl

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Expressioni

    Gene expression databases

    BgeeiE9QJS1.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QJS1.
    SMRiE9QJS1. Positions 31-589, 600-890, 907-1197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation
    Contains 1 FERM domain.UniRule annotation
    Contains 1 SH2 domain.UniRule annotation
    Contains 4 protein kinase domains.UniRule annotation

    Keywords - Domaini

    SH2 domainUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00710000106680.
    KOiK11219.
    OMAiFCDFQDI.
    OrthoDBiEOG7BW0HM.
    TreeFamiTF327041.

    Family and domain databases

    InterProiIPR019749. Band_41_domain.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSiPR01823. JANUSKINASE.
    PR00109. TYRKINASE.
    PR01827. YKINASETYK2.
    SMARTiSM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QJS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT     50
    FSQTSLTAEE VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ 100
    DMNLYFRMRF YFRNWHGMNP QEPAVYRCGF PGAETSSDRA EQGVQLLDSA 150
    SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP QGKHEFMNDV VSLRDLSSEE 200
    EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC IPHSFRQHIR 250
    QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER 300
    IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI 350
    QWHPLQTQES ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC 400
    DFQDISHVVL KERRVHIHLQ DNKCLLLCLC SQAEALSFVA LVDGYFRLTA 450
    DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP FVQAKLWPED GLYLIQWSTS 500
    HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD GWGRSFASLG 550
    DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS 600
    QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG 650
    GTSGQQLRVV LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG 700
    SENIIVTEFV EHGPLDVWLR RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL 750
    VHGNVCGRNI LLARLGLEEG TNPFIKLSDP GVGQGALSRE ERVERIPWTA 800
    PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP SEKERFYTKK 850
    HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV 900
    NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK 950
    ALKEGCGPQL RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY 1000
    VPLGSLRDYL PRHCVGLAQL LLFAQQICEG MAYLHAQHYI HRDLAARNVL 1050
    LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP ECLKECKFYY 1100
    ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT VLRLTELLER 1150
    GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV 1200
    PSVFSVC 1207
    Length:1,207
    Mass (Da):135,901
    Last modified:April 5, 2011 - v1
    Checksum:i7207FF710AC80CE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC163637 Genomic DNA. No translation available.
    RefSeqiNP_001192241.1. NM_001205312.1.
    UniGeneiMm.20249.
    Mm.450004.

    Genome annotation databases

    EnsembliENSMUST00000001036; ENSMUSP00000001036; ENSMUSG00000032175.
    GeneIDi54721.
    KEGGimmu:54721.
    UCSCiuc012gpb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC163637 Genomic DNA. No translation available.
    RefSeqi NP_001192241.1. NM_001205312.1.
    UniGenei Mm.20249.
    Mm.450004.

    3D structure databases

    ProteinModelPortali E9QJS1.
    SMRi E9QJS1. Positions 31-589, 600-890, 907-1197.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001036 ; ENSMUSP00000001036 ; ENSMUSG00000032175 .
    GeneIDi 54721.
    KEGGi mmu:54721.
    UCSCi uc012gpb.1. mouse.

    Organism-specific databases

    CTDi 7297.
    MGIi MGI:1929470. Tyk2.

    Phylogenomic databases

    GeneTreei ENSGT00710000106680.
    KOi K11219.
    OMAi FCDFQDI.
    OrthoDBi EOG7BW0HM.
    TreeFami TF327041.

    Enzyme and pathway databases

    Reactomei REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.

    Miscellaneous databases

    ChiTaRSi TYK2. mouse.
    NextBioi 311570.
    SOURCEi Search...

    Gene expression databases

    Bgeei E9QJS1.

    Family and domain databases

    InterProi IPR019749. Band_41_domain.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSi PR01823. JANUSKINASE.
    PR00109. TYRKINASE.
    PR01827. YKINASETYK2.
    SMARTi SM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QJS1_MOUSE
    AccessioniPrimary (citable) accession number: E9QJS1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3